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Panalon
Techno Drugs LTD.
Generic: Pancuronium Bromide
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Panalon. Please consult your doctor.
CONSULT YOUR DOCTOR
Panalon may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Panalon is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
NOT RELEVANT
Not relevant, as Panalon is intended for use in hospitalised patients.
CAUTION
Panalon should be used with caution in patients with kidney disease. Dose adjustment of Panalon may be needed. Please consult your doctor.
CAUTION
Panalon should be used with caution in patients with liver disease. Dose adjustment of Panalon may be needed. Please consult your doctor.
Medicine Overview of Panalon 4mg/2ml Injection
Introduction
Panalon belongs to a group of medicines called muscle relaxants. It is used along with general anesthesia or sedatives to provide skeletal muscle relaxation during surgical procedures. It is also used to facilitate emergency airway management in patients in intensive care. Panalon is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The medicine is generally well-tolerated with little or no side effects. However, it may cause injection site reactions (such as pain, redness, and...
... Show moreUses of Panalon
- Skeletal mucle relaxation during surgery
Side effects of Panalon
Common
- Injection site reactions (pain, swelling, redness)
How to use Panalon
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Panalon works
Panalon relaxes the muscles by blocking the impulses from the nerves.
Brief Description
Indication
Adjunct to GA for Endotracheal intubation and to provide skeletal muscle ralaxation.
Adult Dose
General Anesthesia Adjunct/Cesarean Section
Load: 0.04-0.1 mg/kg IV
Maintenance: 0.015-0.1 mg/kg IV q30-60min OR
Continuous infusion: 0.1 mg/kg/hr IV
Dose should be calculated based on ideal body weight
Monitoring of muscle twitch response to a peripheral nerve stimulator is advised
Endotracheal Intubation
Bolus dose 0.06-0.1 mg/kg
Usually effective with in 2-3 minutes
Child Dose
Neonates (1 Month Old
Load: 0.04-0.1 mg/kg IV
Maintenance: 0.015-0.1 mg/kg IV q30-60min OR
Continual infusion: 0.1 mg/kg/hr IV
Contraindication
Anuria. Relatively contraindicated in conditions of reduced airway control. Lactation.
Mode of Action
Pancuronium bromide is a non-depolarising neuromuscular blocking agent with curarimimetic action through competitive blockade at the myoneural junction by binding with cholinergic receptor sites.
Precaution
Myasthenia gravis; severe electrolyte disorders; severe CV disease; pregnancy. Hepatic and renal function impairment. Hypothermia; jaundice; hypermagnesaemia, hypocalcaemia, hypokalaemia, hypoproteinaemia, acidosis, alkalosis, hypercalcemia. In obese patients, dose should be based on ideal body wt. Elderly; previous anaphylactic reactions to other neuromuscular-blocking agents. Burn patients (>30% of body) may be resistant to action for 5-70 days after injury. Demyelinating lesions, peripheral neuropathies, denervation, infection, muscle trauma, and DM may antagonise the neuromuscular blockade effects of drug. Neuromuscular diseases, acute intermittent porphyria, Eaton-Lambert syndrome. Maintain adequate airway and respiratory support during use. Lactation: not known if excreted in breast milk; effect on...
... Show moreSide Effect
Tachycardia may occur due to vagal blockade and especially during light anaesthesia. May decrease intra-ocular pressure and induce miosis; excessive salivation; transient rashes and itching; wheezing; elevation in pulse rate, BP, cardiac output; erythema; burning sensation along vein; profound muscle weakness; bronchospasm; hypersensitivity reaction; acute quadriplegic myopathy syndrome, myositis ossificans.
Potentially Fatal: Rare anaphylactoid reactions; bradycardia, bronchospasm, hypotension and CV collapse; respiratory depression.
Interaction
Neuroleptanalgaesia may decrease neuromuscular activity. Action may be prolonged and/or potentiated by aminoglycoside antibiotics, lithium, diazepam, lidocaine (high dose), quinidine, tetracyclines, propranolol, thiamine (high dose), parenteral magnesium sulphate, MAOIs, quinine, protamine, carbamazepine, donepezil and phenytoin (if pancuronium is given concurrently for <1 wk). Action may be decreased by neostigmine, edrophonium, high-dose or long term corticosteroids, adrenaline (may also potentiate effect), azathioprine, theophylline (high doses), clindamycin, nifedipine, piperacillin, polymixins, verapamil, procainamide. Furosemide may increase or decrease effects. TCAs may increase risk of arrhythmias and hypotension during anaesthesia. Potentially Fatal: Potentiated by volatile anaesthetics (isoflurane and enflurane) and local anaesthetics. Prior admin...
... Show moreব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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