12-24 Hours
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Safety Advices
বাংলা
English
UNSAFE
Parixol 88 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Parixol 88 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Parixol 88 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Parixol 88 suppresses serum prolactin and may interfere with breastfeeding.
UNSAFE
Parixol 88 may cause side effects which could affect your ability to drive.
Parixol 88 can cause hallucinations (seeing, hearing or feeling things that are not there). This may affect your ability to drive.
CAUTION
Parixol 88 should be used with caution in patients with kidney disease. Dose adjustment of Parixol 88 may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Parixol 88 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Parixol 88 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Parixol 88 88mcg Tablet
Introduction
Parixol 88 is a prescription medicine used in the treatment of Parkinson's disease and restless leg syndrome (an urge to move the legs usually accompanied or caused by uncomfortable and unpleasant leg sensations). It helps to treat excessive shaking by slowing down the body movements. Parixol 88 should be taken with food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you...
... Show moreUses of Parixol 88
- Parkinson's disease
- Restless leg syndrome
Side effects of Parixol 88
Common
- Dizziness
- Sleepiness
- Nausea
- Dryness in mouth
- Fatigue
- Hallucination
- Constipation
- Peripheral edema
How to use Parixol 88
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Parixol 88 is to be taken with food.
How Parixol 88 works
Parixol 88 works by increasing the action of dopamine, a chemical messenger that is needed to control movement in the brain.
Quick Tips
- You have been prescribed Parixol 88 to treat your symptoms of Parkinson's disease and/or restless leg syndrome.
- It can be taken with or without food. Taking it with food may reduce nausea.
- For restless leg syndrome, take this medicine 2 to 3 hours before bedtime.
- Avoid activities that require you to be alert, such as driving a car until you know how this medication affects you.
- When you first start taking Parixol 88, it may cause sudden drop in your blood pressure when you change positions. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Talk to your doctor in case you develop hallucinations or other changes in your behavior.
- Inform your doctor if you develop compulsive behaviors that are hard to control, such as binge eating, gambling, spending money, and sexual urges.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Parkinson's disease, Restless leg syndrome
Administration
May be taken with or without food. May be taken w/ meals to minimise GI side effects such as nausea.
Adult Dose
Parkinson Disease
Immediate-release: 0.125 mg PO q8hr initially; gradually titrated upward at weekly intervals to target range of 1.5-4.5 mg/day PO divided q8hr
Restless Legs Syndrome
0.125 mg/day PO 2-3 hr before bedtime initially; may be increased every 4-7 days up to 0.5 mg/day (every 14 days if CrCl 20-60 mL/min)
Renal Dose
Parkinson disease
Immediate release
CrCl >50 mL/min: Dosage adjustment not necessary
CrCl 30-50 mL/min: 0.125 mg twice daily initially; not to exceed 0.75 mg TID
CrCl 15-29 mL/min: 0.125 mg qDay; not to exceed 1.5 mg qDay
CrCl 60 mL/min: Dosasge adjustment not necessary
CrCl 20-60 mL/min: Dosage adjustment not necessary but duration between titration should be increased to 14 days
CrCl<20 mL/min: Dosage adjustment not provided by manufacturer's labeling; not studied
Contraindication
Hypersensitivity. Lactation.
Mode of Action
Pramipexole is a nonergot-derivative dopamine receptor agonist which alleviates Parkinsonian motor deficits by directly stimulating postsynaptic dopamine activity on the striatum and substantia nigra It is used as an adjunct to levodopa for the symptomatic management of parkinsonian syndrome in patients w/ advanced disease. It is also used as monotherapy for the initial symptomatic management of parkinsonian syndrome.
Precaution
Psychotic disorder, severe CV disease, augmentation (earlier onset, increase and spread of symptoms). Risk of neuroleptic malignant syndrome w/ abrupt withdrawal. Taper dose at 750 mcg/day for a wk, then reduce by 375 mcg/day thereafter. Renal impairment. Pregnancy and lactation. Patient Counselling Patients should be informed to refrain from activities involving mental alertness and physical coordination after drug intake. Monitoring Parameters Monitor BP, signs and symptoms of fibrosis and orthostatic hypotension, development of impulse control disorder, behavioural changes. Perform periodic skin examinations. Regular ophthalmological testing due to risk of visual disorders.
Side Effect
>10%
Somnolence,Dyskinesia,Hallucinations,Insomnia,Dizziness,Postural hypotension,Nausea,Constipation
1-10% (partial list)
Abnormal dreams, thoughts, or vision,Amnesia,Confusion,Paranoia or delusion,Akathisia,Asthenia,Dry mouth
Interaction
Inhibits active tubular secretion of basic cationic drugs eg, cimetidine. Reduced clearance w/ drugs eliminated by active renal tubular secretion eg, amantadine. Alcohol & other sedatives.
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