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Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Pefla does not cause any harmful side effects.
CONSULT YOUR DOCTOR
Information regarding the use of Pefla during pregnancy is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
Pefla is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Pefla may cause side effects which could affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Pefla in patients with kidney disease. Please consult your doctor.
CAUTION
Pefla should be used with caution in patients with liver disease. Dose adjustment of Pefla may be needed. Please consult your doctor.
Medicine Overview of Pefla 400mg Tablet
Introduction
Pefla is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and soft tissues and lungs (pneumonia). It cures the infection by stopping the further growth of the causative microorganisms. Pefla should be used in the dose and duration as advised by your doctor. It should be taken with food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take...
... Show moreUses of Pefla
- Bacterial infections
Side effects of Pefla
Common
- Nausea
- Diarrhea
- Headache
- Dizziness
How to use Pefla
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pefla is to be taken with food.
How Pefla works
Pefla is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.
What if you forget to take Pefla?
If you miss a dose of Pefla, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Pefla to cure your infection and improve symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Discontinue Pefla and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Brief Description
Indication
Susceptible infections, Gonococcal urethritis, Acute uncomplicated cystitis
Administration
Should be taken with food. Take w/ meals.
Adult Dose
Oral
Susceptible infections
Adult: 400 mg bid.
Acute uncomplicated cystitis in women; Gonococcal urethritis in men
Adult: 800 mg as single dose.
IV Influsion
Adult: 400 mg in 100 or 250 ml of 5% dextrose slow infusion over an hour bid.
Renal Dose
Renal impairment: Dose reduction may be necessary.
Contraindication
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.
Mode of Action
Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction.
Precaution
Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn.
Side Effect
Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction.
Interaction
Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin.
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