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Pen-A
Renata Limited
Generic: Ampicillin
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Pen-A does not cause any harmful side effects.
SAFE IF PRESCRIBED
Pen-A is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Pen-A is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Pen-A does not usually affect your ability to drive.
CAUTION
Pen-A should be used with caution in patients with kidney disease. Dose adjustment of Pen-A may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Pen-A in patients with liver disease. Please consult your doctor.
Medicine Overview of Pen-A 125mg/5ml Powder for Suspension
Introduction
Pen-A is a penicillin-type of antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract (eg. pneumonia), urinary tract, skin and soft tissue, and typhoid fever. Pen-A is also used to prevent infection of the heart valves (bacterial endocarditis) in people with pre-existing heart disease. It is a broad-spectrum antibiotic that fights and stops the growth of many types of bacteria. This medicine should be taken on an empty stomach. Use it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at...
... Show moreUses of Pen-A
- Bacterial infections
Side effects of Pen-A
Common
- Rash
- Vomiting
- Allergic reaction
- Nausea
- Diarrhea
How to use Pen-A
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Pen-A is to be taken empty stomach.
How Pen-A works
Pen-A is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
- Pen-A is used to treat infections caused by bacteria.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect. Taking probiotics along with Pen-A may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking this medicine and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Brief Description
Indication
Adult: PO Susceptible infections 0.25-0.5 g 6 hrly. Typhoid and paratyphoid fever 1-2 g 6 hrly. Duration: 2 wk (acute infections); 4-12 wk (carriers). Uncomplicated gonorrhoea W/ probenecid: 2 g as single dose. IV/IM: IV Intrapartum prophylaxis against group B streptococcal infections Initial, 2 g, then 1 g 4 hrly until delivery. Septicaemia 150-200 mg/kg/day. Start with IV admin for 3 days, then IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after patient has become asymptomatic or when there is evidence of bacterial eradication. IV/IM Susceptible infections 250-500 mg 6 hrly. Meningitis 2-3 g 4-6 hrly, may...
... Show moreAdministration
May reduce the efficacy of OC. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion w/ probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases ampicillin-induced skin reactions. Reduced absorption w/ chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere w/ the bactericidal action of ampicillin.
Adult Dose
Renal failure; patients with lymphatic leukaemia or HIV infections; pregnancy and lactation.
Lactation: Excreted in breast milk, use caution
Renal Dose
Ampicillin exerts bactericidal action on both gm+ve and gm-ve organisms. Its spectrum includes gm+ve organisms eg, S pneumoniae and other Streptococci, L monocytogenes and gm-ve bacteria eg, M catarrhalis, N gonorrhoea, N meningitidis, E coli, P mirabilis, Salmonella, Shigella, and H influenzae. Ampicillin exerts its action by inhibiting the synthesis of bacterial cell wall.
Contraindication
Susceptible infections
Child:
PO: 50–100 mg/kg/day divided q6hr if 20 kg 1–2 g/day divided q6hr
IV/IM:
Child: 50–200 mg/kg/day q6h
300–400 mg/kg/day endocarditis/meningitis q4–6h
Mode of Action
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Reconstitution: IM: Add 1.5 mL water for inj to 500 mg vial contents. IV: Dissolve 500 mg in 10 mL water for inj.
Precaution
Bacterial infections, Endocarditis, Typhoid fever, Community-acquired pneumonia, Uncomplicated gonorrhea, Susceptible infections, Bacterial meningitis, Paratyphoid fever, Septicaemia, Intrapartum prophylaxis against group B streptococcal infections
Side Effect
Renal impairment: Patients undergoing haemodialysis should receive an additional dose after the session.
CrCl (ml/min)
<10 Dose reduction or increase in dose interval.
Pregnancy Category Note
GI upset, nausea, vomiting, diarrhoea; blood dyscrasias; urticaria, exfoliative dermatitis, rash; fever, seizures; interstitial nephritis.
Potentially Fatal: Anaphylactic shock; pseudomembranous colitis; neuromuscular hypersensitivity; electrolyte imbalance.
Interaction
Hypersensitivity; infectious mononucleosis.
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