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Safety Advices
বাংলা
English
UNSAFE
Pendoril 4 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Pendoril 4 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Pendoril 4 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Pendoril 4 may cause side effects which could affect your ability to drive.
Pendoril 4 usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in some patients. This may affect your driving ability.
CAUTION
Pendoril 4 should be used with caution in patients with kidney disease. Dose adjustment of Pendoril 4 may be needed. Please consult your doctor.
Caution should be advised in patients with renal impairment.
CAUTION
Pendoril 4 should be used with caution in patients with liver disease. Dose adjustment of Pendoril 4 may be needed. Please consult your doctor.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.
Medicine Overview of Pendoril 4mg Tablet
Introduction
Pendoril 4 belongs to a group of medicines known as angiotensin converting enzyme (ACE) inhibitor. It is widely used to treat high blood pressure and heart failure and may be prescribed after a heart attack. It also lowers the chances of having a heart attack or stroke. Pendoril 4 can be prescribed either alone or in combination with other medicines. It should be taken on an empty stomach. This medicine should be taken at the same time each day to get the most benefit. It is important to continue taking it regularly even if you feel well or even if...
... Show moreUses of Pendoril 4
- Hypertension (high blood pressure)
- Prevention of heart attack and stroke
- Heart failure
Side effects of Pendoril 4
Common
- Decreased blood pressure
- Cough
- Increased potassium level in blood
- Fatigue
- Weakness
- Dizziness
How to use Pendoril 4
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pendoril 4 is to be taken empty stomach.
How Pendoril 4 works
Pendoril 4 is an angiotensin converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently.
What if you forget to take Pendoril 4?
If you miss a dose of Pendoril 4, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Pendoril 4 can make you feel dizzy for the first few days, so rise slowly if you have been sitting or lying down. You can also prefer taking it at bedtime to avoid dizziness throughout the day.
- Let your doctor know about any cough, or throat irritation that does not go away.
- It may increase the level of potassium in blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Hypertension, IHD, Heart failure
Administration
Should be taken on an empty stomach. Take before meals.
Adult Dose
Oral
Adult
Hypertension
4-8 mg PO qDay or divided q12hr
Maximum: 16 mg/day PO divided q12hr
Stable Coronary Artery Disease (CAD)
4 mg PO qDay for 2 weeks, THEN increase as tolerated to 8 mg/day PO divided q12hr
Reduce risk of cardiovascular mortality or MI in patients with stable CAD
Heart Failure
2 mg PO qDay initially to maximum 8-16 mg PO qDay
Elderly: Initially, 2 mg once daily. Dose may be increased to max 8 mg
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<15 2 mg on dialysis days.
15-30 2 mg on alternate days.
30-60 2 mg
Contraindication
History of angioedema related to previous ACE inhibitor treatment. Pregnancy (2nd/3rd trimesters).
Mode of Action
Perindopril is an ACE inhibitor, which acts by inhibiting the conversion of angiotensin I to angiotensin II, reducing the activity of the sympathetic nervous system and inhibiting enzyme kininase, which is involved in the conversion of bradykinin and other substances.
Precaution
History of airway surgery. Withdraw if there is significant increase in LFTs. Risk factors for hyperkalaemia; monitor potassium closely. Patients dependent on renin-angiotensin-aldosterone system; consider withdrawal in patients with progressive deterioration in renal function. Collagen vascular disease. Hypovolaemia; monitor BP with the 1st dose. Unilateral renal artery stenosis and pre-existing renal insufficiency; valvular aortic stenosis. Before, during, or immediately after anaesthesia. May impair ability to drive or operate machinery. Lactation.
Lactation: not known if distributed into breast milk; use caution
Side Effect
>10%
Headache (23%),Cough (12%)
1-10%
Dizziness (8%),Back pain (6%),Lower extremity pain (5%),Abnormal ECG (2%),Palpitation (1%),Depression (2%),Somnolence (1%),Menstrual disorder (1%),Edema (4%),ALT increased (2%),Sexual dysfunction (male 1%),Sleep disorder (3%),Chest pain (2%),Nausea/vomiting (2%),Flatulence (1%),Rash (2%),Hyperkalemia (1%),Tinnitus (2%)
Frequency Not Defined
Intestinal angioedema,Liver failure (rare),Leukopenia,Pruritus,Stroke,Syncope,Urinary retention,Vertigo,Amnesia
Angioedema, More frequent in black patients (0.1%), Angioedema of lips, More frequent in black patients (0.1%), Angioedema of throat, More frequent in black patients (0.1%)
Potentially Fatal: Anaphylactoid reactions, angioedema.
Interaction
May enhance hypotensive effect w/ diuretics. Additive hyperkalaemic effect w/ K supplements, K-sparing diuretics, and other drugs (e.g. ciclosporin, heparin, indometacin). May increase serum levels and toxicity of lithium. Antihypertensive effect may be reduced by aspirin or other NSAIDs. Coadministration w/ NSAIDs may also increase the risk of renal impairment. Increased risk of hypoglycaemia w/ antidiabetic agents. Rarely, nitritoid reactions occur w/ concomitant use of gold (sodium aurothiomalate).
Potentially Fatal: Increased risk of hypotension, hyperkalaemia and changes in renal function (including acute renal failure) w/ aliskiren in patients w/ diabetes or renal impairment.
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