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Penicillin G Sodium
Renata Limited
Generic: Benzyl Penicillin
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Penicillin G Sodium does not cause any harmful side effects.
SAFE IF PRESCRIBED
Penicillin G Sodium is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Penicillin G Sodium is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Penicillin G Sodium does not usually affect your ability to drive.
CAUTION
Penicillin G Sodium should be used with caution in patients with kidney disease. Dose adjustment of Penicillin G Sodium may be needed. Please consult your doctor.
CAUTION
Penicillin G Sodium should be used with caution in patients with liver disease. Dose adjustment of Penicillin G Sodium may be needed. Please consult your doctor.
Medicine Overview of Penicillin G Sodium 5LacIU Injection
Introduction
Penicillin G Sodium is an antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract, skin and soft tissue, and sexually transmitted diseases like Syphilis. Penicillin G Sodium is also used to prevent some infections such as Rheumatic fever and infection of the heart valves (bacterial endocarditis) in people with pre-existing heart disease. It is a penicillin-type of antibiotic, which mainly fights and stops the growth of the gram-positive type of bacteria. This tablet may be swallowed with or without food, but it should be used regularly at...
... Show moreUses of Penicillin G Sodium
- Bacterial infections
- Syphilis
- Prevention of rheumatic fever
Side effects of Penicillin G Sodium
Common
- Rash
- Vomiting
- Allergic reaction
- Nausea
- Diarrhea
How to use Penicillin G Sodium
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Penicillin G Sodium may be taken with or without food, but it is better to take it at a fixed time.
How Penicillin G Sodium works
Penicillin G Sodium is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
- You have been prescribed Penicillin G Sodium for the treatment of bacterial infections.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.
Brief Description
Indication
Meningitis, Anthrax, Community-acquired pneumonia, Bacterial endocarditis, Septicemia, Diphtheria, Syphilis, Cellulitis, Infective endocarditis, Gonorrhea, Aspiration pneumonia, Lung abscess, Septic Arthritis, Gangrene, Meningococcal meningitis, Pneumococcal meningitis, Botulism
Administration
IM Administration Do not inject near artery or nerve (may result in permanent neurologic damage) Neonates, infants, small children: Midlateral aspect of thigh preferable Older children and adults: Deep IM injection in upper outer quadrant of buttock Because of high concentration of suspended matter, needle may be blocked if injection is not made at slow, steady rate Reconstitution: Loosen the powd, then, hold the vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake the vial vigorously after all the diluent has been added. Depending on the route of admin, reconstitute...
... Show moreAdult Dose
Adult: IV Bacterial endocarditis W/ aminoglycoside: 1.2 g 4 hrly. Intrapartum prophylaxis against group B streptococcal infection Initial: 3 g, then 1.5 g 4 hrly until delivery.
Meningococcal meningitis; Pneumococcal meningitis 2.4 g 4 hrly. Up to 18 g/day in meningococcal meningitis.
IV/IM Susceptible infections 0.6-4.8 g/day in divided doses.
Child Dose
Infant & Children: Bacterial Infection
IV, IM 100,000–250,000 U/kg/day q4–6h
Max daily dose is 24 million U.
Renal Dose
Renal impairment: Dosing interval should be no more frequent than every 8-10 hr.
Contraindication
Hypersensitivity to penicillins.
Mode of Action
Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other beta-lactamases.
Precaution
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route.
Lactation: Excreted into breast milk, caution advised
Side Effect
Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis.
Potentially Fatal: Anaphylaxis.
Pregnancy Category Note
Pregnancy Category: B
Lactation: Excreted into breast milk, caution advised
Interaction
Probenecid
Increases and prolongs serum penicillin levels.
Tetracycline
May antagonize the bactericidal effect of penicillin.
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