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Perinase
Beximco Pharmaceuticals Ltd.
Generic: Fluticasone Propionate Nasal prep
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Perinase may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Perinase is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Medicine Overview of Perinase 50mcg/spray Nasal Spray
Introduction
Perinase is a steroid. It relieves the symptoms of allergic rhinitis such as runny nose, sneezing and sinus discomfort. It works by blocking the production of certain chemical messengers that cause inlammation (swelling) and allergies, thus relieving the discomfort and irritation in your nose. You should always use Perinase as advised by your doctor. To get the full benefit of the medicine you should take it regularly. Normally, you should blow your nose gently before using it, keep one nostril closed while applying the medicine into the other and then sniff hard to make sure it reaches deep into the...
... Show moreUses of Perinase
- Sneezing and runny nose due to allergies
Side effects of Perinase
Common
- Nasal irritation
How to use Perinase
Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breath gently and keep the head upright. Repeat the same process for the other nostrils.
How Perinase works
Perinase is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.
Quick Tips
- The right way to use the nasal spray:
- Avoid deep breathing as it will cause medication to go back to the throat and make it less effective.
- Do not share the bottle with anyone else so that you do not spread germs.
- Perinase should be avoided in patients with recent nasal ulcers, nasal surgery, or nasal trauma.
Brief Description
Indication
Seasonal and Perennial allergic and nonallergic, rhinitis, Nasal polyps
Adult Dose
Nasal
Allergic rhinitis
Adults: 2 sprays(100mcg) in each nostril once a day, preferably in the morning. In some cases 2 sprays into each nostril twice daily, not exceeding 4 sprays.
Nasal polyps
Adult: 4 sprays (200 mcg) into each nostril 1-2 times daily for at least 4-6 wk.
Child Dose
Nasal
Allergic rhinitis
Children over 12 years: 2 sprays(100mcg) in each nostril once a day, preferably in the morning. In some cases 2 sprays into each nostril twice daily, not exceeding 4 sprays.
Children under 12 years (4 - 11 Years): 1 spray (50mcg) in each nostril once a day. The maximum total daily dosage should not exceed 4 sprays.
Nasal polyps
Child: >16 yr 4 sprays (200 mcg) into each nostril 1-2 times daily for at least 4-6 wk.
Contraindication
Hypersensitivity.
Mode of Action
Fluticasone utilises a fluorocarbothioate ester linkage at the C17 position. It has potent vasoconstrictive and anti-inflammatory activity, but weak HPA inhibitory effect when applied topically.
Precaution
Rarely, immediate hypersensitivity reactions or contact dermatitis may occur after the administration of Fluticasone Propionate nasal spray. Rare instances of wheezing, nasal septum perforation, cataracts, glaucoma and increased intraocular pressure have been reported following the intranasal application of corticosteroids, including Fluticasone Propionate. Although systemic effects have been minimal with recommended doses of Fluticasone Propionate nasal spray, potential risk increases with larger doses. Therefore, larger than recommended doses of Fluticasone Propionate nasal spray should be avoided.
Lactation: Unknown whether distributed in breast milk; caution advised
Side Effect
>10%
Headache (17%),URI (15%)
1-10%
Nasal congestion (8%),Pharyngitis (6-8%),Asthma symptoms (3-7%),Fever (1-5%),Dysphonia (4%),Cough (3-4%),Nasal discharge (1-3%),Aches and pains (1-3%),Flu-like syndrome (1-3%),Bronchitis (1-3%),Diarrhea (1-3%),Abdominal pain (1-3%),Nasal ulcer (1%)
Frequency Not Defined
Loss of taste
With the nasal spray, drying of the nose and an increase in the incidence of nosebleeds may occur.
Potentially Fatal: Paradoxical bronchospasm.
Pregnancy Category Note
Pregnancy
Available data on inhaled or intranasal fluticasone propionate use in pregnant women have not reported a clear association with adverse developmental outcomes
Fluticasone propionate crossed the placenta following subcutaneous administration to mice and rats and oral administration to rabbits
Lactation
There are no available data on fluticasone propionate in human milk, effects on breastfed child, or effects on milk production
Developmental and health benefits of breastfeeding should be considered and adverse effects on breastfed child from treatment or from an underlying maternal condition
Interaction
May lead to increased plasma concentrations of fluticasone when used with CYP4503A4 inhibitors such as ritonavir.
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