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Perindal
Opsonin Pharma Limited
Generic: Indapamide + Perindopril Erbumine
Safety Advices
বাংলা
English
UNSAFE
Perindal may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Perindal is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Perindal is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Perindal may cause side effects which could affect your ability to drive.
Perindal usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in some patients. This may affect your driving ability.
CAUTION
Perindal should be used with caution in patients with kidney disease. Dose adjustment of Perindal may be needed. Please consult your doctor.
Caution should be advised in patients with renal impairment.
CAUTION
Perindal should be used with caution in patients with liver disease. Dose adjustment of Perindal may be needed. Please consult your doctor.
Medicine Overview of Perindal 1.25mg+4mg Tablet
Introduction
Perindal is a medicine used to treat hypertension (high blood pressure). It is a combination of two medicines that helps to control blood pressure when a single medication is not effective. It helps to reduce the chances of any future heart attack and stroke. Perindal should be taken on empty stomach, preferably in the morning to avoid frequent urination at night. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition...
... Show moreUses of Perindal
- Hypertension (high blood pressure)
Side effects of Perindal
Common
- Nausea
- Diarrhea
- Stomach pain
- Constipation
- Vomiting
- Headache
- Vertigo
- Dizziness
- Altered vision
- Numbness
- Ringing in ear
- Breathlessness
- Indigestion
- Allergic reaction
- Skin rash
- Itching
- Cramps
- Fatigue
How to use Perindal
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perindal is to be taken empty stomach.
How Perindal works
Perindal is a combination of two medicines: Perindopril and indapamide which lower blood pressure effectively. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessels so that blood flows more smoothly and the heart can pump blood more efficiently. Indapamide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- You have been prescribed Perindal for the treatment of high blood pressure.
- It also lowers your risk of stroke and heart attack.
- Take it in the morning with breakfast, to avoid getting up at night to urinate.
- Perindal may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Inform you doctor about any cough, or throat irritation that doesn't go away.
- Perindal may cause dehydration. Drink plenty of fluids and Inform your doctor if you develop extreme thirst, muscle weakness or very dry mouth.
- Your doctor may regularly monitor your blood pressure, kidney function and the levels of salts such as potassium in your blood while you are taking this medicine.
- Do not take Perindal if you’re pregnant or planning pregnancy. It can cause birth defects or be fatal to your unborn baby.
Brief Description
Indication
Hypertension
Adult Dose
Oral
Hypertension
Adult: 1 tab once daily in the morning.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Avoid use.
30-60 Dose adjustment may be needed
Contraindication
Hypersensitivity. Severe renal impairment (CrCl <30 ml/min), hypokalaemia, severe hepatic impairment or hepatic encephalopathy, history of angioedema associated with treatment with an ACE inhibitor, children. Dialysis patients or patients with untreated decompensated heart failure. Hereditary/idiopathic angioneurotic oedema. Pregnancy and lactation.
Mode of Action
Perindopril is an ACE inhibitor, which acts by inhibiting the conversion of angiotensin I to angiotensin II, reducing the activity of the sympathetic nervous system and inhibiting enzyme kininase, which is involved in the conversion of bradykinin and other substances. Indapamide is a sulfonamide derivative with an indole ring. It inhibits the reabsorption of sodium in the cortical dilution segment, thus increasing urinary output, resulting in an antihypertensive effect.
Precaution
Impaired renal function, risk of hypotension and electrolyte imbalance. Regular monitoring of renal function and plasma levels of potassium are recommended. Blood glucose levels should be monitored in diabetic patients especially in those with low serum potassium levels. Increased risk of neutropenia/agranulocytosis in immunosuppressed patients. Treatment should be discontinued immediately if there is angioneurotic oedema of the face, extremities, lips, tongue, glottis and/or larynx.
Side Effect
Dry cough, headache, bradycardia, dizziness, asthenia, hypokalaemia and orthostatic hypotension. GI effects such as constipation, dry mouth, nausea, epigastric pain, anorexia, abdominal pain and taste disturbance.
Interaction
Additive effect with other antihypertensive agents and diuretics. Increased chance of hypokalaemia with corticosteroids, corticotropin and amphotericin.
Potentially Fatal: Increased risk of lithium toxicity. Hypokalaemia enhances digitalis toxicity with cardiac gycosides.
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