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Perkinil
Square Pharmaceuticals PLC.
Generic: Procyclidine Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
Perkinil may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Perkinil may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CAUTION
Perkinil should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
UNSAFE
Perkinil may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Perkinil should be used with caution in patients with kidney disease. Dose adjustment of Perkinil may be needed. Please consult your doctor.
CAUTION
Perkinil should be used with caution in patients with liver disease. Dose adjustment of Perkinil may be needed. Please consult your doctor.
Medicine Overview of Perkinil 10mg/2ml Injection
Introduction
Perkinil is a prescription medicine used in the treatment of Parkinson's disease and drug induced abnormal movements. It helps by improving muscle control and reducing the stiffness of the muscle, so that they can move easily. Perkinil should be taken with food as it reduces the side effects with this medicine. It should be taken at the same time each day, this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember....
... Show moreUses of Perkinil
- Parkinson's disease
Side effects of Perkinil
Common
- Dryness in mouth
- Nausea
- Vomiting
- Constipation
- Blurred vision
- Dizziness
- Lightheadedness
- Dilatation of pupil
- Upper abdominal pain
- Urinary retention
How to use Perkinil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perkinil is to be taken with food.
How Perkinil works
Perkinil is a muscle relaxing medication. It works by decreasing the activity of excess acetylcholine in the brain. This improves muscle control and reduces stiffness. It helps patients with Parkinson's disease by improving muscle control and reducing stiffness so that they can move more naturally. It is also used to treat movement disorder (restlessness, involuntary movements or muscle spasm ) which can be caused by certain drugs.
Quick Tips
- Perkinil helps treat Parkinson's disease and drug-induced abnormal movements.
- Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
- It may cause dry eyes. Avoid wearing contact lenses and inform your doctor if it bothers you.
- It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Inform your doctor if you suffer from glaucoma or if you have trouble passing urine.
- Do not stop taking Perkinil without talking to your doctor first as that may cause worsening of symptoms.
- Monitoring of intraocular pressure is required while taking this medicine, as an increase in eye pressure may cause blurry vision.
- You may be asked for regular monitoring of hypotension, kidney, liver, and cardiac disorder while taking this medicine.
Brief Description
Indication
Parkinsonism, Drug-induced extrapyramidal syndrome
Adult Dose
Oral
Parkinsonism and drug-induced extrapyramidal syndrome
Adult: As hydrochloride: Initially, 2.5 mg tid, increased gradually by 2.5-5 mg every 2-3 days if required. Maintenance: 10-30 mg/day in 3-4 divided doses. Up to 60 mg daily may be required in some cases.
Parenteral
Parkinsonism and drug-induced extrapyramidal syndrome
Adult: Emergency cases: IV admin: 5-10 mg, higher doses may be needed; IM admin: 5-10 mg as a single dose, may repeat after 20 minutes if needed, to a max of 20 mg daily.
Elderly: Lower doses are required.
Child Dose
Oral
Dystonia in children
Child: 7-12 yr: 1.25 mg tid;
12-18 yr: 2.5 mg tid.
For emergency cases, a single dose may be given via IM or IV inj:
<2 yr: 0.5-2 mg;
2-10 yr: 2-5 mg and 10-18 yr: 5-10 mg.
Contraindication
Urinary outflow obstruction, prostatic hyperthrophy, narrow-angle glaucoma, paralytic ileus and pyloric stenosis.
Mode of Action
Procyclidine is a tertiary amine antimuscarinic which acts by blocking excess acetylcholine at cerebral synapses. It also exhibits direct antispasmodic effect on smooth muscle.
Precaution
Patient w/ mental disorders, CV disease (e.g. tachycardia, cardiac arrhythmias, hypertention, hypotension). Hepatic and renal impairment. Avoid abrupt withdrawal. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause blurred vision, dizziness, confusion or disorientation, if affected, do not drive or operate machinery. Monitoring Parameters Monitor symptoms of extrapyramydal syndrome or Parkinson's disease, pulse, anticholinergic effects (e.g. CNS, bowel and bladder function).
Side Effect
Dry mouth, mydriasis, blurred vision, lightheadedness, giddiness, disorientation, GI effects (e.g. nausea, vomiting, epigastric distress, constipation), allergic reaction (e.g. rash), muscular weakness; vertigo, confusion, hallucinations at high doses; tremor, acute suppurative parotitis.
Interaction
Increased plasma concentrations w/ paroxetine. Enhanced anticholinergic action w/ MAOIs and other anticholinergic drugs. Reduced therapeutic effect w/ cholinergic drugs. May antagonise the effect of parasympathomimetic agents. May reduce the absorption and therapeutic effect of sublingual or buccal nitrate tab. May reduce the efficacy of levodopa. May antagonise the GI effects of cisapride, domperidone and metoclopramide. May potentiate the vagolytic effects of quinidine. May reduce the absorption of ketoconazole.
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