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Perol
Ambee Pharmaceuticals Ltd.
Generic: Haloperidol
Safety Advices
বাংলা
English
UNSAFE
Perol may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Perol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Perol is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
If Perol is used, monitor the baby for excessive sleepiness.
UNSAFE
Perol may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Perol is safe to use in patients with kidney disease. No dose adjustment of Perol is recommended.
However, patients with severe kidney disease may need to be started at a lower dose as it may cause excessive sleepiness in these patients.
CAUTION
Perol should be used with caution in patients with liver disease. Dose adjustment of Perol may be needed. Please consult your doctor.
Medicine Overview of Perol 5mg/ml Injection
Introduction
Perol is a prescription medicine used in the treatment of schizophrenia (a mental disorder in which a person develops unreal thoughts and behavior). It is also used to treat Tourette syndrome (chronic multiple motor and vocal problems and involuntary responses) in adults and children. Perol can also be used for treating psychosis, mania, severe behavior problems in adults and children. It may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in...
... Show moreUses of Perol
- Schizophrenia
Side effects of Perol
Common
- Abnormality of voluntary movements
- Constipation
- Dryness in mouth
- Increased prolactin level in blood
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Sleepiness
- Weight gain
How to use Perol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perol may be taken with or without food, but it is better to take it at a fixed time.
How Perol works
Perol is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.
Quick Tips
- Perol helps treat schizophrenia.
- It is less likely to cause weight gain as compared to other similar medicines.
- Use caution while driving or doing anything that requires concentration as Perol may cause dizziness and sleepiness.
- Avoid drinking alcohol while taking this medicine as it can cause increased dizziness.
- Inform your doctor if you experience any abnormal movements or have difficulty controlling movements.
- It may affect how your body regulates your temperature. Avoid getting dehydrated and drink plenty of fluids.
- Your doctor may check your heart function and level of electrolytes such as sodium and magnesium before you start treatment with this medicine and regularly thereafter.
- Do not stop taking Perol without talking to your doctor first as it may cause worsening of symptoms.
Brief Description
Indication
Schizophrenia, Delirium, Hiccups, Acute psychosis, Hyperactivity, Aggression, Agitation and confusion, Tic disorders, Tourette syndrome, Chorea, Nausea and vomiting, Dementia.
Administration
May be taken with or without food. May be taken w/ meals to minimise GI irritation.
Adult Dose
Oral Psychoses Adult: 0.5-5 mg bid/tid, may increase up to 100 mg daily in severe or resistant cases. Usual maintenance: 3-10 mg daily. Tourette's syndrome; Severe tics Adult: Initially, 0.5-1.5 mg tid. Up to 30 mg daily may be required in Tourette's syndrome; adjust dose carefully to obtain optimum response; usual maintenance: 4 mg daily. Short-term adjunct in severe anxiety or behavioral disturbances Adult: 0.5 mg bid. Restlessness and confusion Adult: 1-3 mg every 8 hr. Intractable hiccup Adult: 1.5 mg tid, adjust according to response. Intramuscular Acute psychosis Adult: Doses range from 2-10 mg, may be given every hr...
... Show moreChild Dose
12 years: Moderate disease, 0.5-2 mg PO q8-12hr initially; severe disease, 3-5 mg PO q8-12hr; not to exceed 30 mg/day Tourette Disorder 3-12 years: 0.5 mg/day PO initially; dose increased by 0.5 mg every 5-7 days until therapeutic effect achieved, then reduced to lowest effective maintenance level of 0.05-0.075 mg/kg/day PO divided q8-12hr >12 years: 0.5-2 mg PO q8-12hr initially; if severe symptoms necessitate increased dosage, titrate upward to 3-5 mg PO q8-12hr; if patient remains inadequately controlled, daily doses up to 100 mg have been used (safety not determined) Behavioral Disorders 3-12 years: 0.5 mg/day PO initially; dose increased...
... Show moreContraindication
Severe toxic CNS depression; preexisting coma; Parkinson's disease; lactation.
Mode of Action
Haloperidol blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It produces calmness and reduces aggressiveness with disappearance of hallucinations and delusions.
Precaution
Parkinsonism; epilepsy, allergy, angle-closure glaucoma, benign prostatic hyperplasia; severe cardiac or hepatic disease; extremes in temp (hot and cold weather); presence of acute infections or leucopenia; hyperthyroidism; pregnancy, elderly, children. Patients receiving anticoagulants. Discontinue upon signs of neurological toxicity in patients taking haloperidol and lithium.
Lactation: Drug enters breast milk; not recommended
Side Effect
Extrapyramidal symptoms
Akathisia,Dystonia,Muscle stiffness,Neuroleptic malignant syndrome (NMS; infrequent but serious),Parkinsonism,Tardive dyskinesia
Common
Anticholinergic effects,Sedation,Weight gain,Erectile dysfunction,Oligomenorrhea or amenorrhea
Less common
Orthostatic hypotension (after IM injection), tachycardia
Agitation, anxiety, cerebral edema, depression, dizziness, euphoria, headache, insomnia, poikilothermia, restlessness, weakness, confusion
Anorexia, constipation, dyspepsia, ileus, decreased gag reflex
Lens opacities (prolonged use)
Uncommon
ECG changes,Photosensitivity,Pruritus,Diarrhea,Blood dyscrasia,Ejaculatory disorder,Galactorrhea
Rare
Seizure,Cholestatic jaundice,Priapism
Potentially Fatal: Neuroleptic malignant syndrome
Interaction
Carbamazepine and rifampicin reduce plasma concentrations. Symptoms of CNS depression may be enhanced by CNS depressants e.g. alcohol, hypnotics, general anaesthetics, anxiolytics and opioids. May reduce antihypertensive action of guanethidine. May increase risk of arrhythmia when used with drugs that prolong QT interval or diuretics that can cause electrolyte imbalance. May increase plasma levels of haloperidol when used with clozapine or chlorpromazine.
Potentially Fatal: Increases lithium blood levels and may predispose to neuroleptic malignant syndrome.
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