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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with P-Les. Please consult your doctor.
CONSULT YOUR DOCTOR
P-Les may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
P-Les is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
P-Les does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of P-Les in patients with kidney disease. Please consult your doctor.
CAUTION
P-Les should be used with caution in patients with liver disease. Dose adjustment of P-Les may be needed. Please consult your doctor.
Medicine Overview of P-Les 500mg Tablet
Introduction
P-Les is an antiparasitic medication. It is used in the treatment of worm infections. It works by killing the worms and this treats your infection. P-Les should be used in the dose and duration as advised by your doctor. It should be taken with food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned. Some people may experience stomach pain as a side effect of this medicine. Please...
... Show moreUses of P-Les
- Worm infections
Side effects of P-Les
Common
- Abdominal pain
How to use P-Les
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. P-Les may be taken with or without food, but it is better to take it at a fixed time.
How P-Les works
P-Les affects the permeability of the cell membrane thereby killing the worms.
Quick Tips
- You have been prescribed P-Les to treat a variety of parasitic worm infections.
- It should be taken with food.
- If you are unable to swallow the whole tablet, it may be crushed or chewed and swallowed with a full glass of water.
- It can be harmful to an unborn baby. Do not take it during pregnancy or breastfeeding. Use birth control measures to prevent pregnancy while taking P-Les.
- Your doctor may monitor your blood counts and liver function before you start taking this medicine and regularly throughout your treatment.
- Avoid being near people who are sick or have infections. Inform your doctor if you develop signs of infection.
- Do not skip doses and finish the prescribed course, even if you start to feel better. Stopping it early may increase your risk of further infection.
Brief Description
Indication
Enterobiasis, Hookworm infections, Filariasis, Toxocariasis, Ascarisis, Trichuriasis, Trichostrongyliasis, Trichinellosis, Dracunculiasis
Administration
May be taken with or without food. May be swallowed whole, chewed, or crushed and mixed with food
Adult Dose
Oral Adults: Enterobiasis : A single tablet( 100 mg) or 1 teaspoonful (5 ml) of the suspension. If cure is not achieved 3 wk after treatment, a second course of treatment is advised Ascariasis, Ancylostomiasis, Trichuriasis : 100 mg bid for 3 consecutive days or 500 mg as single dose or 1 teaspoonful (5 ml) bid for 3 consecutive days. If cure is not achieved 3 wk after treatment, a second course of treatment is advised Taeniasis & strongyloidiasis : 100 mg bid for 3 consecutive days If cure is not achieved 3 wk after treatment, a second course of...
... Show moreChild Dose
Oral Enterobiasis Child: >2 A single tablet( 100 mg) or 1 teaspoonful (5 ml) of the suspension. If cure is not achieved 3 wk after treatment, a second course of treatment is advised Ascariasis, Ancylostomiasis, Trichuriasis : Child: >1 yr 100 mg bid for 3 consecutive days or 500 mg as single dose or 1 teaspoonful (5 ml) bid for 3 consecutive days. If cure is not achieved 3 wk after treatment, a second course of treatment is advised Taeniasis & strongyloidiasis : 100 mg bid for 3 consecutive days If cure is not achieved 3 wk after treatment, a...
... Show moreContraindication
Hypersensitivity. Infants and children <2 yr.
Mode of Action
Mebendazole inhibits formation of helminth microtubules. It selectively and irreversibly blocks the uptake of glucose and other nutrients in susceptible helminths, resulting in endogenous depletion of glycogen stores in the helminth.
Precaution
Hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Periodic assessment of haematologic, hepatic, and renal function; check for helminth ova in faeces w/in 3-4 wk following the initial therapy.
Lactation: Excretion in breast milk unknown; use caution
Side Effect
Transient diarrhoea, abdominal pain, nausea, vomiting, headache, tinnitus, numbness, fever, alopecia, rash, pruritus, urticaria, angioedema, flushing, hiccups, cough, weakness, drowsiness, chills, hypotension, seizures, transient abnormalities in LFT (e.g. increased serum concentrations of aminotransferases, glutamyltransferase alkaline phosphatase, and/or bilirubin), hepatitis, increased BUN, decreased Hb concentration and/or hematocrit, leucopenia, eosinophilia, haematuria, cylindruria, migration of roundworms through the mouth and nose.
Potentially Fatal: Myelosuppression, manifested as neutropenia (including agranulocytosis) and/or thrombocytopenia.
Interaction
Decreased plasma concentrations w/ carbamazepine and phenytoin. Increased plasma concentrations w/ cimetidine.
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