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Pregalex
Sharif Pharmaceuticals Ltd.
Generic: Pregabalin
Safety Advices
বাংলা
English
UNSAFE
Pregalex may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Pregalex may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Pregalex is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Pregalex may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Pregalex should be used with caution in patients with kidney disease. Dose adjustment of Pregalex may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Pregalex is safe to use in patients with liver disease. No dose adjustment of Pregalex is recommended.
Medicine Overview of Pregalex 150mg Capsule
Introduction
Pregalex is a medicine used to relieve pain caused by nerve damage (neuropathic pain) due to diabetes, shingles (herpes zoster infection), spinal cord injury, or other conditions. It is also used to treat widespread muscle pain and stiffness in people with fibromyalgia. Pregalex belongs to the anti-epileptic group of medicines and can be used to treat certain types of seizures (fits) in combination with other medicines. It may also be prescribed to treat the symptoms of excessive anxiety in generalized anxiety disorder if other medicines are not suitable. You can take Pregalex with or without food, but it is important...
... Show moreUses of Pregalex
- Neuropathic pain
- Epilepsy/Seizures
- Fibromyalgia
Side effects of Pregalex
Common
- Blurred vision
- Difficulty in paying attention
- Dizziness
- Dryness in mouth
- Edema (swelling)
- Sleepiness
- Weight gain
How to use Pregalex
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Pregalex may be taken with or without food, but it is better to take it at a fixed time.
How Pregalex works
Pregalex is an antiepileptic medication. When given for epilepsy, it is believed to work by reducing the abnormal electrical activity in the brain, thus preventing seizures. It is also used to treat nerve pain where it blocks pain by interfering with pain signals travelling through the damaged nerves and the brain. For treatment of anxiety, it is believed to work by stopping the release of certain chemical messengers (neurotransmitters) that make you feel anxious.
What if you forget to take Pregalex?
If you miss a dose of Pregalex, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Pregalex should be taken as per the dose and duration prescribed by your doctor.
- It may cause sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- It may cause blurring or loss of vision. Inform your doctor immediately if you notice any vision changes.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
- Do not stop taking the medication suddenly without talking to your doctor as it may worsen your underlying condition.
Brief Description
Indication
Anxiety, Fibromyalgia, Post herpetic Neuralgia, Partial seizures, Pain from diabetic neuropathy, Neuropathic pain associated with spinal cord injury
Administration
May be taken with or without food.
Adult Dose
Oral Neuropathic pain, Postherpetic Neuralgia Adult: Initially, 150 mg/day, may increase to 300 mg/day after 3-7 days. Max: 600 mg/day after a 7-day interval. All doses to be given in 2 or 3 divided doses. Diabetic Peripheral Neuropathic Pain Initial: 50 mg PO q8hr Maintenance: May increase to 100 mg PO q8hr within 1 week, as needed; not to exceed 300 mg/day Adjunct in partial seizures Adult: Initially, 150 mg/day, may increase to 300 mg/day after a wk. Max: 600 mg/day. All doses to be given in 2 or 3 divided doses. Fibromyalgia Adult: Initially, 150 mg/day, may increase to...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Haemodialysis: 25-100 mg immediately after each 4-hr haemodialysis session.
CrCl (ml/min) Dosage Recommendation
30 to <60 75 mg/day. Max: 300 mg/day. All doses to be given in 2 or 3 divided doses.
15 to <30 Initially, 25-50 mg/day. Max: 150 mg/day. All doses to be given as a single dose or in 2 divided doses.
<15 Initially, 25 mg/day. Max: 75 mg/day. All doses to be given as a single dose.
Contraindication
Hypersensitivity. Pregnancy, lactation. Driving or working with machines, or do other dangerous activities.
Mode of Action
Pregabalin is an analog of the neurotransmitter GABA. It binds potently to the alpha2-delta subunit resulting in modulation of Ca channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, calcitonin gene-related peptide and substance P.
Precaution
Abrupt or rapid discontinuation of Pregabalin may produce some symptoms including insomnia, nausea, headache and diarrhoea. So Pregabalin should be tapered gradually over a minimum of 1 week rather than discontinued abruptly. Pregabalin treatment may associate with creatine kinase elevations. It should be discontinued if myopathy is diagnosed or suspected or if markedly elevated creatine kinase levels occur. Discontinue treatment if patients develop severe angioedema. Regular vision check is recommended. May decrease platelet count and prolong PR interval. Patient w/ history of angioedema episodes, severe CV disease, renal impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive, operate...
... Show moreSide Effect
>10%
Dizziness (8-45%),Somnolence (4-36%),Peripheral edema (16%),Ataxia (1-20%),Fatigue (5-11%),Xerostomia (1-15%),Weight gain (16%),Tremor (11%),Blurred vision (1-12%),Diplopia (12%)
1-10%
Asthenia (5%),Edema (8%),Facial edema (1%),Incoordination (2%),Vomiting (1-3%),Balance disorder (2-9%),Myoclonus (4%),Nasopharyngitis pain (1-3%),Flu-like syndrome (1-2%)
<1%
Addiction,Anemia,Diarrhea,Gynecomastia and breast enlargement,Epididymitis,Esophagitis,Dysmenorrhea,Dystonia,Heart failure,Hirsutism,Uveitis
<0.1%
Neutropenia, first degree heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis, suicidal thoughts or behavior
Interaction
May potentiate the effects of lorazepam. Additive CNS depressant effects w/ opiates and benzodiazepines. May increase risk of angioedema w/ ACE inhibitors. May increase risk of wt gain and peripheral oedema w/ thiazolidinediones.
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