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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Profen 400.
CONSULT YOUR DOCTOR
Profen 400 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Profen 400 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Profen 400 does not usually affect your ability to drive.
CAUTION
Profen 400 should be used with caution in patients with kidney disease. Dose adjustment of Profen 400 may be needed. Please consult your doctor.
Use of Profen 400 is not recommended in patients with severe kidney disease. Long term use of this medicine can affect the kidney function.
CAUTION
Profen 400 should be used with caution in patients with liver disease. Dose adjustment of Profen 400 may be needed. Please consult your doctor.
Use of Profen 400 is not recommended in patients with severe liver disease.
Medicine Overview of Profen 400mg Tablet
Introduction
Profen 400 is a pain relieving medicine. It is used to treat many conditions such as headache, fever, period pain, toothache, colds, and mild arthritis. It is also a common ingredient in many cold and flu remedies. Profen 400 should be taken with food to avoid stomach upset and reduce side effects. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as it will become less effective if you do. The medicine is well...
... Show moreUses of Profen 400
- Pain relief
- Fever
Side effects of Profen 400
Common
- Vomiting
- Stomach pain
- Nausea
- Indigestion
- Heartburn
How to use Profen 400
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Profen 400 is to be taken with food.
How Profen 400 works
Profen 400 is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).
Quick Tips
- You have been prescribed Profen 400 to relieve pain and inflammation.
- Take it with food or milk to prevent upset stomach.
- Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
- Do not take indigestion remedies (antacids) within two hours of taking Profen 400.
- Avoid consuming alcohol while taking Profen 400 as it can increase your risk of stomach problems.
- Inform your doctor if you have a history of heart disease or stroke.
- Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
Brief Description
Indication
Rheumatoid arthritis, Osteoarthritis, Pain, Fever, Pericarditis, Dysmenorrhea, Patent ductus arteriosus, Inflammation, Musculoskeletal and joint disorders
Administration
Should be taken with food.
Adult Dose
Pain/Fever/Dysmenorrhea
200-400 mg PO q4-6hr; not to exceed 1.2 g unless directed by physician
Inflammatory Disease
400-800 mg PO q6-8hr; not to exceed 3.2 g/day
Osteoarthritis, Rheumatoid Arthritis
300 mg, 400 mg, 600 mg, or 800 mg PO q6-8hr; not to exceed 3.2 g/day
Severe hepatic impairment: Avoid use
Child Dose
Fever
6 months to 12 years
5-10 mg/kg/dose PO q6-8hr; not to exceed 40 mg/kg/day
Pain
4-10 mg/kg/dose PO q6-8hr; not to exceed 40 mg/kg/day
Juvenile Idiopathic Arthritis
30-50 mg/kg/24hr PO divided q8hr; not to exceed 2.4 g/day
Renal Dose
Significantly impaired renal function: Monitor closely; consider reduced dosage if warranted
Contraindication
Active peptic ulcer; hypersensitivity. Neonates with congenital heart disease, suspected necrotising enterocolitis and active bleeding (parenteral).
Mode of Action
Ibuprofen inhibits synthesis of prostaglandins in body tissues by inhibiting cyclooxygenase-1 and 2. It has anti-inflammatory, analgesic and antipyretic properties.
Precaution
Asthma; renal or hepatic disorders; bleeding disorders; CV disease. Pregnancy, lactation.
Lactation: Drug excreted into breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)
Side Effect
1-10%
Dizziness (3-9%),Epigastric pain (3-9%),Heartburn (3-9%),Constipation (1-3%),Nausea (3-9%),Rash (3-9%),Tinnitus (3-9%),Edema (1-3%),Fluid retention (1-3%),Headache (1-3%),Vomiting (1-3%)
<1%
Acute renal failure (sometimes with acute tubular necrosis or hyperkalemia, polyuria, azotemia, cystitis, hematuria, decreased creatinine clearance, elevations in blood urea nitrogen (BUN) or creatinine without other manifestations of renal failure)
Agranulocytosis,Aplastic anemia,Erythema multiforme,Erythematous macular rashes,Exfoliative dermatitis,Hemolytic anemia (with or without positive direct antiglobulin test results),Neutropenia,Thrombocytopenia (with or without purpura),Toxic epidermal necrolysis (Lyell syndrome) and photosensitivity reactions
Potentially Fatal: Severe CV thrombotic events. Severe GI bleeding, ulceration and perforation.
Pregnancy Category Note
Pregnancy category: C; D in 3rd trimester or near delivery. At >30 weeks' gestation; may cause premature closure of ductus arteriosus
Interaction
Increased risk of GI bleeding w/ warfarin, corticosteroids, SSRIs and aspirin. May reduce the natriuretic effects of diuretics. Reduced antihypertensive effect of ACE inhibitors and angiotensin II receptor antagonists. May increase toxicity of lithium and methotrexate. Increased nephrotoxicity w/ ciclosporin and tacrolimus.
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