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Arofil 300 SR
Incepta Pharmaceuticals Ltd.
Generic: Theophylline
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Arofil 300 SR.
CONSULT YOUR DOCTOR
Arofil 300 SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Arofil 300 SR is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoiding breastfeeding for 2-4 hours after Arofil 300 SR can further decrease the exposure of medicine to the baby.
SAFE
Arofil 300 SR does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Arofil 300 SR is safe to use in patients with kidney disease. No dose adjustment of Arofil 300 SR is recommended.
CAUTION
Arofil 300 SR should be used with caution in patients with liver disease. Dose adjustment of Arofil 300 SR may be needed. Please consult your doctor.
Medicine Overview of Arofil 300 SR 300mg Tablet
Introduction
Arofil 300 SR is used to treat and prevent symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which flow of air to the lung is blocked). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe. Arofil 300 SR can be taken with the food in evening. But take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve...
... Show moreUses of Arofil 300 SR
- Chronic obstructive pulmonary disease (COPD)
- Asthma
Side effects of Arofil 300 SR
Common
- Upset stomach
- Vomiting
- Headache
- Nausea
- Restlessness
How to use Arofil 300 SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arofil 300 SR is to be taken with food.
How Arofil 300 SR works
Arofil 300 SR is a bronchodilator. It works by relaxing the muscles of the airways and widens airways. This makes breathing easier.
Quick Tips
- You have been prescribed OD PHYLLIN 600 MG TABLET for prevention and treatment of asthma and chronic obstructive pulmonary disease (COPD).
- It should be taken at the same time each day, preferably in the evening after food.
- It does not work right away and should not be used to relieve sudden breathing problems. Always keep a fast-acting (rescue) inhaler with you.
- Your doctor may take regular blood test to monitor potassium level and the level of this medicine in your body.
- Notify your doctor if you have ever been diagnosed with kidney, liver or heart disease, or if you have a smoking history. Your dose may need to be adjusted.
- Do not discontinue use without consulting your doctor, even if you feel better.
Brief Description
Indication
Asthma, Chronic obstructive pulmonary disease, Bronchospasm, Apnoea of prematurity
Administration
May be taken with or without food, at least 1 hour before or 2 hour after meal.
Adult Dose
Oral Acute Asthma Loading Dose: 5 mg/kg loading dose (patient not receiving theophylline or aminophylline). Maintenance of Asthma, COPD General Dosing Recommendations The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Maintenance Dose: 10-16/mg/kg/day Adult: Starting Dose: 300-400mg/day once or twice daily. After 3 days if tolerated, increase dose to 400-600mg/day once or twice dialy. Max: 600mg/day Adult: As SR/CR Cap or Tab, 200/300 mg: One tablet/capsule every 12 hourly. As 400mg tablet/capsule One tab/cap...
... Show moreChild Dose
Oral Acute Asthma Loading Dose: 5 mg/kg loading dose If no theophylline has been administered in the previous 24 hours 2.5 mg/kg loading dose If theophylline has been administered in the previous 24 hours Maintenance of Asthma General Dosing Recommendations The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Maintenance Dose: Child 1.5-6 months: 10 mg/kg/day PO in divided doses 6-12 months: 12-18 mg/kg/day PO in divided doses 1-9 years: 8 mg/kg PO (extended release)...
... Show moreContraindication
Hypersensitivity to xanthine derivatives, porphyria.
Mode of Action
Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion.
Precaution
Patient w/ peptic ulceration, hyperthyroidism, DM, glaucoma, severe hypoxemia, epilepsy, HTN, heart failure, cardiac arrhythmias or other CV disease, acute febrile illness, COPD, cor pulmonale; smokers. Hepatic or renal impairment. Elderly and childn. Pregnancy and lactation. Monitoring Parameters Monitor heart rate, CNS effects, resp rate, arterial or capillary blood gases, theophylline levels.
Lactation: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants; serious adverse effects in infant are unlikely unless mother has toxic serum theophylline concentration
Side Effect
Nausea, vomiting, epigastric pain, abdominal cramps, anorexia, diarrhoea, haematemesis; headache, irritability, restlessness, nervousness, insomnia, dizziness, reflex hyperexcitability, seizures; palpitations, sinus tachycardia, extrasystoles, increased pulse rate, flushing, circulatory failure, hypotension, ventricular arrhythmias; transient increase in urinary frequency, dehydration, twitching of fingers and hands, tachypnoea, elevated serum AST concentrations.
Potentially Fatal: Convulsions, cardiac arrhythmias, severe hypotension or cardiac arrest.
Interaction
Increased plasma concentrations w/ allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon alfa, macrolide antibiotics, quinolones, OCs, tiabendazole, viloxazine, Ca channel blockers. Reduced plasma concentrations w/ phenytoin and other antiepileptics, ritonavir, rifampicin, sulfinpyrazone, aminoglutethimide, barbiturates, carbamazepine. Enhanced lithium excretion. May potentiate hypokalaemia w/ corticosteroids and diuretics. Risk of synergistic toxicity when given w/ halothane or ketamine. May antagonise effects of adenosine and competitive neuromuscular blockers. Increased bronchospasm w/ β-blockers.
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