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Prolert
Square Pharmaceuticals PLC.
Generic: Fluoxetine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Prolert.
CONSULT YOUR DOCTOR
Prolert may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Prolert is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Prolert may cause side effects which could affect your ability to drive.
SAFE IF PRESCRIBED
Prolert is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Prolert may not be needed in these patients. Please consult your doctor.
CAUTION
Prolert should be used with caution in patients with liver disease. Dose adjustment of Prolert may be needed. Please consult your doctor.
Medicine Overview of Prolert 20mg/5ml Oral Solution
Introduction
Prolert is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is widely prescribed to treat depression and other mental health conditions like panic disorder and obsessive-compulsive disorder. Prolert helps many people to recover from depression by improving their mood and relieving anxiety and tension. It is also used to treat bulimia nervosa (an eating disorder), where it reduces binge-eating and purging (vomiting). The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you...
... Show moreUses of Prolert
- Depression
- Panic disorder
- Obsessive-compulsive disorder
- Bulimia nervosa
Side effects of Prolert
Common
- Erectile dysfunction
- Indigestion
- Influenza like syndrome
- Loss of appetite
- Low sexual desire
- Nausea
- Sore throat
- Sweating
- Tremor
- Weakness
- Yawning
- Abnormal dreams
- Delayed ejaculation
- Dryness in mouth
- Insomnia (difficulty in sleeping)
- Nervousness
- Sleepiness
- Sinus infection
How to use Prolert
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Prolert may be taken with or without food, but it is better to take it at a fixed time.
How Prolert works
Prolert is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of panic and obsessive disorders.
Quick Tips
- Take Prolert in the morning since it can keep you awake if taken late at night.
- It may cause anxiety and agitation when you first start taking it.
- It may cause weight loss and decreased appetite.
- Don't drive or do anything requiring concentration until you know how Prolert affects you.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Inform your doctor if you experience difficulty having an orgasm or have decreased sex drive.
- The addiction/dependence potential of Prolert is very less.
- Do not stop taking medication suddenly without doctor consultation as that may lead to agitation, anxiety, and dysphoria.
Brief Description
Indication
Panic disorder, Obsessive compulsive disorder, Trichotillomania, Premenstrual dysphoric disorder, Major depression, Post-traumatic stress disorder, Bulimia nervosa, Body dysmorphic disorder, Binge eating disorder
Administration
May be taken with or without food.
Adult Dose
Oral Depression Adult: Initially, 20 mg once daily. May gradually increase up to max 80 mg daily in 2 divided doses, if no clinical response after several wk. Bulimia nervosa Adult: 60 mg daily as a single or in divided doses. Hepatic impairment: Reduce dose and/or dosing frequency. Obsessive compulsive disorder Adult: Initially, 20 mg once daily, increased up to 60 mg daily if no clinical response after several wk. Max: 80 mg daily in 2 divided doses. Premenstrual dysphoric disorder Adult: 20 mg daily continuously. Alternatively, 20 mg daily to be started 14 days before menstruation and continued until...
... Show moreChild Dose
Oral
Depression
Child: >8 yr Initially, 10 mg daily, may increase to 20 mg daily after 1-2 wk.
Low wt childn: Initially, 10 mg daily, may increase to 20 mg daily after several wk, only if clinical response is insufficient.
Obsessive compulsive disorder
Child: >7 yr Initially, 10 mg daily, may increase to 20 mg daily after 2 wk; increase further up to 60 mg daily after several wk as necessary.
Low-wt childn: Initially, 10 mg daily, may increase to 20-30 mg daily after several wk, if required.
Renal Dose
Renal impairment: Use caution; drug accumulation may occur with severe renal impairment
Contraindication
Severe renal or hepatic failure; hypersensitivity; lactation; concomitant MAOIs or within 2 wk of MAOI withdrawal.
Mode of Action
Fluoxetine is a potent and highly selective inhibitor of serotonin (5-HT) re-uptake. No affinity for adrenoceptors or histamine, GABA-B, or muscarinic receptors.
Precaution
Unstable epilepsy, liver and renal impairment, cardiac disease, diabetes, electroconvulsive therapy, bleeding disorders, closed-angle glaucoma; pregnancy. May impair performace of skilled tasks; withdraw gradually. Close monitoring of clinical worsening and behavioural changes during the 1st few mth of treatment or when there are dose changes.
Lactation
Excreted in milk; avoid (AAP states effect on nursing infants is unknown but may be of concern)
Side Effect
>10%
Headache (20-25%),Nausea (12-29%),Insomnia (10-33%),Anorexia (4-17%),Anxiety (6-15%),Asthenia (10-15%),Diarrhea (8-18%),Nervousness (8-14%),Somnolence (5-17%),Tremor (3-13%),Weakness (7-21%)
1-10%
Dizziness (9%),Dry mouth (6-10%),Dyspepsia (6-10%),Sweating (5-10%),Decreased libido (2-5%),Abnormal taste (>1%),Agitation (>1%),Chest pain (>1%),Chills (>1%),Confusion (>1%),Ear pain (>1%),Hypertension (>1%),Increased appetite (>1%),Palpitation (>1%),Sleep disorder (>1%),Tinnitus (>1%),Urinary frequency (>1%),Vomiting (>1%),Weight gain (>1%)
Frequency Not Defined
Dysglycemia in patients with DM
Risk of seizure with concomitant electroconvulsive therapy (rare)
Potentially Fatal: Rarely, systemic events possibly related to vasculitis have been reported in patients with rash but may be serious involving lungs, kidney and liver.
Pregnancy Category Note
Pregnancy category: C Treatment of pregnant women during the first trimester: There are no adequate and well-controlled clinical studies on the use of fluoxetine in pregnant women, but 1 prospective cohort study conducted by the European Network of Teratology Information Services reported an increased risk of cardiovascular malformations in infants born to women (N = 253) exposed to fluoxetine during the first trimester of pregnancy, compared with infants of women (N = 1359) who were not exposed to fluoxetine Use late in the third trimester associated with complications in newborns and may require prolonged hospitalization, respiratory support, and tube feeding...
... Show moreInteraction
May cause transient shift in plasma conc of tightly protein bound drugs e.g. warfarin and digoxin, resulting in adverse effects. T1/2 of diazepam is prolonged. Avoid concurrent use with clopidogrel.
Potentially Fatal: Serious reactions when combined with MAOIs; at least 14 days should elapse after MAOIs withdrawal before starting fluoxetine treatment or at least 5 wk should elapse after fluoxetine treatment before starting MAOIs therapy. Two-fold increase in plasma levels of other antidepressants when combined with fluoxetine. Monitor lithium levels when combined.
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