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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Arolef.
UNSAFE
Arolef is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Arolef is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Arolef may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Arolef should be used with caution in patients with kidney disease. Dose adjustment of Arolef may be needed. Please consult your doctor.
UNSAFE
Arolef is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Arolef 20mg Tablet
Introduction
Arolef is used in the treatment of rheumatoid arthritis and psoriatic arthritis. It helps in slowing down the progression of the disease and provide relief from pain, swelling, and redness. Arolef can be taken with or without food. You should take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. Using this medicine may cause some common side effects such as nausea, headache, dyspepsia, rash, diarrhea, increased liver enzymes, and respiratory tract infection. Consult with your...
... Show moreUses of Arolef
- Rheumatoid arthritis
- Psoriatic arthritis
Side effects of Arolef
Common
- Nausea
- Headache
- Rash
- Diarrhea
- Increased liver enzymes
- Respiratory tract infection
How to use Arolef
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Arolef may be taken with or without food, but it is better to take it at a fixed time.
How Arolef works
Arolef blocks the action of certain chemical messengers that are responsible for inflammation, swelling and redness associated with certain autoimmune diseases. It suppresses the underlying disease process, rather than simply treating the disease.
What if you forget to take Arolef?
If you miss a dose of Arolef, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Arolef to control the symptoms and slow down the progression of rheumatoid arthritis.
- It will take 6-8 weeks for Arolef to work. Hence, keep taking the medicine.
- Get blood tests done every 4 weeks. This is to make sure that Arolef is not harming your liver or blood counts.
- Avoid alcohol when taking Arolef as it could harm your liver.
- Do not take it during pregnancy or breastfeeding. Tell your doctor if you become pregnant while taking Arolef.
- Arolef may increase the risk of infection. Avoid being close to people with cold, flu or other contagious illnesses.
- Tell your doctor if you experience nausea or diarrhea.
Brief Description
Indication
Rheumatoid arthritis, Psoriatic arthritis
Administration
May be taken with or without food.
Adult Dose
Oral
Rheumatoid arthritis; Psoriatic arthritis
Adult: Loading dose: 100 mg once daily for 3 days. Maintenance: 10-20 mg once daily.
Hepatic impairment: Contraindicated.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Mild: No dosage adjustment needed.
Moderate to Severe: Contraindicated.
Contraindication
Significant hepatic impairment, compromised immune function including bone marrow dysplasia or severe uncontrolled infection; concurrent vaccination with live vaccines. Pregnancy, lactation.
Mode of Action
Leflunomide is an immunomodulating agent and DMARD. It inhibits pyrimidine synthesis by inhibiting dihydroorotate dehydrogenase enzyme activity resulting in antiproliferative and anti-inflammatory effects.
Precaution
Renal and hepatic impairment; Women with childbearing potential. Caution should be taken for those female with child bearing potential who are not using reliable contraception and for the subject of renal insufficiency. Leflunomide should be stopped before becoming pregnant. Liver function should be monitored before starting treatment. Monitor blood counts and BP regularly. Avoid alcohol.
Lactation: not known if excreted in breast milk
Side Effect
>10%
Diarrhea (17%),Respiratory infections (15%)
1-10% (selected)
Alopecia (10%),Hypertension (10%),Rash (10%),Nausea (9%),Bronchitis (7%),Headache (7%),Abdominal pain (5%),Abnormal LFT's (5%),Accidental injury (5%),Back pain (5%),Dyspepsia (5%),UTI (5%),Dizziness (4%),Infection (4%),Joint disorder (4%),Pruritus (4%),Weight loss (4%),Anorexia (3%),Cough (3%),Gastroenteritis (3%),Pharyngitis (3%),Stomatitis (3%),Tenosynovitis (3%),Vomiting (3%),Weakness (3%),Allergic reaction (2%),Chest pain (2%),Dry skin (2%),Eczema (2%),Pain (2%),Paresthesia (2%),Pneumonia (2%),Rhinitis (2%),Sinusitis (2%),Synovitis (2%)
Potentially Fatal: Hepatotoxicity.
Interaction
Cholestyramine and activated charcoal may decrease plasma concentration of active metabolite. Concurrent use of methotrexate and other hepatotoxic drugs may increase the risk of hepatotoxicity. Rifampicin increases serum levels of the active metabolite.
Potentially Fatal: May enhance the adverse effects of live vaccines.
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