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Prozine
Zenith Pharmaceuticals Ltd.
Generic: Promethazine Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
Prozine may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Prozine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Prozine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
For prolonged use and repeated doses of Prozine, observe the baby for excessive sleepiness.
UNSAFE
Prozine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Prozine is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Prozine may not be needed in these patients. Please consult your doctor.
However, caution is advised in patients with severe kidney disease as it may cause excessive sleepiness in them.
CAUTION
Prozine should be used with caution in patients with liver disease. Dose adjustment of Prozine may be needed. Please consult your doctor.
Medicine Overview of Prozine 25mg Tablet
Introduction
Prozine used in the treatment of various allergic conditions like runny nose, sneezing, congestion, itching and watery eyes. It also treats nausea, vomiting and insomnia (difficulty in sleeping) in adults and used as a sedative (sleep causing) in children (for 5 years and above). Prozine should be taken with or without food, but take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for...
... Show moreUses of Prozine
- Nausea
- Vomiting
Side effects of Prozine
Common
- Dryness in mouth
- Blurred vision
- Headache
- Dizziness
How to use Prozine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Prozine may be taken with or without food, but it is better to take it at a fixed time.
How Prozine works
Prozine is an antiallergic medication. When your body is exposed to an allergen (pollen, animal dander, house dust etc.), it produces a chemical called histamine. This causes watery eyes, runny or blocked nose, sneezing, skin rashes, itching etc. Prozine works by blocking the action of histamine, thereby relieving these symptoms. It also works directly on several areas of the brain to prevent nausea/vomiting and help you feel more relaxed.
What if you forget to take Prozine?
If you miss a dose of Prozine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Prozine helps treat nausea and vomiting.
- It may also be used for the short-term treatment of sleeping difficulties (insomnia) in adults and as a sedative in children.
- Use caution while driving or doing anything that requires concentration as Prozine can cause dizziness and sleepiness.
- Do not drink alcohol while taking this medication as it may cause increased sleepiness.
- It may make your skin more sensitive to sunlight. Avoid exposing your skin to strong sunlight, use a sunscreen lotion or make sure your skin is protected with clothing.
- Do not take it for longer than 7 days. If your symptoms worsen or do not improve after 7 days, talk to your doctor.
- Stop taking it at least three days before taking an allergy test as it can affect the test results.
Brief Description
Indication
Allergic conditions, Nausea and vomiting, Motion sickness, Insomnia
Administration
May be taken with or without food.
Adult Dose
Oral Allergic conditions Adult: As promethazine HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily. Prophylaxis of motion sickness Adult: As promethazine HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As promethazine teoclate: 25 mg given on the night or 1-2 hr before travelling. Short-term management of insomnia Adult: As promethazine HCl: 20-50 mg at night. Parenteral Allergic conditions; Sedation Adult: As promethazine HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not...
... Show moreChild Dose
Oral
Allergic conditions
Child: As promethazine HCl:
2-5 yr 5-15 mg daily in 1 or 2 divided doses;
>5-10 yr 10-25 mg daily in 1 or 2 divided doses.
Prophylaxis of motion sickness
Child: As promethazine HCl:
2-5 yr 5 mg;
>5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.
Short-term management of insomnia
Child: As promethazine HCl:
2-5 yr 15-20 mg;
>5-10 yr 20-25 mg.
Parenteral
Allergic conditions; Sedation
Child: As promethazine HCl: 5-10 yr 6.25-12.5 mg by deep IM.
Renal Dose
Renal impairment: Dose reduction may be required.
Contraindication
Patients in coma or suffering from CNS depression of any cause. Childn <2 yr. SC and intra-arterial admin. Concurrent use w/ or w/in 14 days of MAOI use.
Mode of Action
Promethazine, a phenothiazine derivative, blocks postsynaptic dopaminergic receptors in the brain and has a strong alpha-adrenergic blocking effect. It competitively binds to H1-receptors.
Precaution
Patient w/ asthma, bronchitis or bronchiectasis; severe coronary artery disease, narrow-angle glaucoma, epilepsy, bladder neck or pyloro-duodenal obstruction, Reye's syndrome, bone marrow depression, Hepatic and renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause marked drowsiness, if affected, do not drive or operate machinery. Avoid prolonged exposure to sunlight. Monitoring Parameters Monitor mental status; signs and symptoms of tissue injury (IV inj).
Lactation: Not known whether drug crosses into breast milk; discontinue drug, or do not nurse
Side Effect
Neuroleptic Malignant Syndrome (NMS); CV effects (e.g. bradycardia, tachycardia, transient HTN, hypotension; jaundice, blood dyscrasias, extrapyramidal effects; IV inj: Severe tissue injury (e.g. gangrene), pain and burning, paralysis, thrombophlebitis, severe spasm of distal vessels, necrosis. Sedation, Confusion, Disorientation, Blurred vision, Hallucinations, Dystonias, Catatonic states, Euphoria, Excitation, Impotence, Urinary retention
Potentially Fatal: Resp depression and apnoea esp in childn.
Interaction
Masks ototoxicity of aminoglycoside antibiotics. May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates and opioids.
Potentially Fatal: Ventricular arrhythmias when used with drugs that prolong QT interval. Increased risk of extrapyramydal effects w/ MAOIs.
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