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Purinethol

Tablet-(50mg)
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Glaxo SmithKline Pharmaceuticals Ltdchevron-right

Generic: Mercaptopurine

Stock AvailableStock: Available
1 Tablet
৳37.05
৳40.76
9% OFF

Medicine Overview of Purinethol 50mg Tablet

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Introduction

Purinethol is used in the treatment of blood cancer. It shows its working by decreasing the number of red blood cells, which is produced by the body. Purinethol can be taken with or without food or you can have it one hour before or 2 hours after the meal. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, rash, diarrhea, and loss of appetite. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You have to avoid driving or attention seeking activity if you experience dizziness while taking this medicine. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Purinethol

  • Blood cancer

Side effects of Purinethol

Common
  • Nausea
  • Vomiting
  • Rash
  • Decreased white blood cell count (neutrophils)
  • Intestinal ulcer
  • Anemia (low number of red blood cells)
  • Increased bilirubin in the blood
  • Low blood platelets
  • Increased transaminase level in blood
  • Diarrhea
  • Loss of appetite

How to use Purinethol

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Purinethol may be taken with or without food, but it is better to take it at a fixed time.

How Purinethol works

Purinethol interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.

Quick Tips

  • Purinethol is used for the treatment of cancer of the blood.
  • Take it with or without food.
  • Do not drive or do anything requiring concentration until you know how it affects you.
  • Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
  • Your doctor may get regular blood and urine tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
  • Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.

Brief Description

Indication

Acute lymphatic leukaemia, Crohn's disease

Administration

Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. Ensure adequate fluid intake.

Adult Dose

Acute Lymphatic Leukemia Induction: 2.5 mg/kg PO qDay; usually 100-200 mg PO qDay in average adult (other agents preferred) May increase by 5 mg/kg/day after 4 weeks Maintenance: 1.5-2.5 mg/kg PO qDay Reduce dose by 75% if concomitant allopurinol administration Crohn's disease Adult: Initially 1-1.5 mg/kg daily, may increase to 125 mg daily. Hepatic impairment: Dosage may need to be reduced.

Child Dose

Acute Lymphatic Leukemia Starting dose: 1.25-2.5 mg/kg (50-75 mg/m²) PO qDay Maintenance: 1.5-2.5 mg/kg PO qDay in combination with methotrexate

Renal Dose

Renal Impairment: Dosage may need to be reduced.

Contraindication

Pregnancy and lactation. Prior resistance to mercaptopurine or thioguanine; severe liver disease; severe bone marrow suppression.

Mode of Action

Mercaptopurine is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid. The nucleotides inhibit several reactions which ultimately interferes with nucleic acid synthesis and prevents the formation of RNA and DNA.

Precaution

Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) deficiency; porphyria. Lactation: not known if excreted in breast milk, do not nurse

Side Effect

>10% Elevated LFT's (15%) 1-10% Nausea (10%),Vomiting (10%),Stomatitis (3-10%),Thrombocytopenia (3-10%),Rash (1-3%),Diarrhea (1-3%),Dizziness (1-3%),Alopecia (1-3%),Leukopenia (1-3%) Frequency Not Defined Fatigue,Anorexia,Headache,Chills and fever,Chest pain,Mucositis,Upper respiratory infection,Cough,Ulceration of intestine,Ulcerative stomatitis,Myelosuppressionm,Decreased hematocrit,Hepatotoxicity,Decreased resistance to infections,Hyperuricemia,Nephrotoxicity,Increased risk of pancreatitis in pts with IBD,Hyperpigmentation of skin,Arthralgias,Eye discomfort,Tinnitus Potentially Fatal: Myelosuppression; hepatotoxicity, cholestatic jaundice.

Interaction

Anticoagulant action of warfarin may be inhibited by mercaptopurine. Enhanced toxicity with myelosuppressive drugs. Potentially Fatal: Effects enhanced by allopurinol (reduce dose of mercaptopurine). Other hepatotoxic drugs (e.g. doxorubicin) potentiate toxicity.

Buy Purinethol from Arogga

In Bangladesh, you can get the original Purinethol. Select your favorite one from a large collection of Medicine products. Order from App to get more offers and better experience.

What is the price of Purinethol in Bangladesh?

The latest price of Purinethol in Bangladesh is 37.05৳. You can buy Purinethol at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Asked Questions (FAQ)

Is Purinethol authentic?

Yes. Arogga sources Purinethol products from trusted suppliers, distributors, or manufacturers. Products are verified before delivery.

Does Arogga deliver all over Bangladesh?

Arogga delivers most products across Bangladesh. However, refrigerated or cold-chain medicines are delivered only within Dhaka. Delivery of some other products may also depend on product condition, storage requirements, and delivery location.

Is Cash on Delivery (COD) available for Purinethol?

Yes. Cash on Delivery is available for all products in eligible locations across Bangladesh. Availability may vary depending on the product and delivery location.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on product availability, delivery location, and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy..

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Purinethol. Please consult your doctor.
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CONSULT YOUR DOCTOR
Purinethol is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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CONSULT YOUR DOCTOR
Purinethol is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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SAFE
Purinethol does not usually affect your ability to drive.
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CAUTION
Purinethol should be used with caution in patients with kidney disease. Dose adjustment of Purinethol may be needed. Please consult your doctor.
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CAUTION
Purinethol should be used with caution in patients with liver disease. Dose adjustment of Purinethol may be needed. Please consult your doctor. Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.