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Purinethol
Glaxo SmithKline Pharmaceuticals Ltd
Generic: Mercaptopurine
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Purinethol. Please consult your doctor.
CONSULT YOUR DOCTOR
Purinethol is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Purinethol is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Purinethol does not usually affect your ability to drive.
CAUTION
Purinethol should be used with caution in patients with kidney disease. Dose adjustment of Purinethol may be needed. Please consult your doctor.
CAUTION
Purinethol should be used with caution in patients with liver disease. Dose adjustment of Purinethol may be needed. Please consult your doctor.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.
Medicine Overview of Purinethol 50mg Tablet
Introduction
Purinethol is used in the treatment of blood cancer. It shows its working by decreasing the number of red blood cells, which is produced by the body. Purinethol can be taken with or without food or you can have it one hour before or 2 hours after the meal. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking...
... Show moreUses of Purinethol
- Blood cancer
Side effects of Purinethol
Common
- Nausea
- Vomiting
- Rash
- Decreased white blood cell count (neutrophils)
- Intestinal ulcer
- Anemia (low number of red blood cells)
- Increased bilirubin in the blood
- Low blood platelets
- Increased transaminase level in blood
- Diarrhea
- Loss of appetite
How to use Purinethol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Purinethol may be taken with or without food, but it is better to take it at a fixed time.
How Purinethol works
Purinethol interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.
Quick Tips
- Purinethol is used for the treatment of cancer of the blood.
- Take it with or without food.
- Do not drive or do anything requiring concentration until you know how it affects you.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Your doctor may get regular blood and urine tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Brief Description
Indication
Acute lymphatic leukaemia, Crohn's disease
Administration
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. Ensure adequate fluid intake.
Adult Dose
Acute Lymphatic Leukemia
Induction: 2.5 mg/kg PO qDay; usually 100-200 mg PO qDay in average adult (other agents preferred)
May increase by 5 mg/kg/day after 4 weeks
Maintenance: 1.5-2.5 mg/kg PO qDay
Reduce dose by 75% if concomitant allopurinol administration
Crohn's disease
Adult: Initially 1-1.5 mg/kg daily, may increase to 125 mg daily.
Hepatic impairment: Dosage may need to be reduced.
Child Dose
Acute Lymphatic Leukemia
Starting dose: 1.25-2.5 mg/kg (50-75 mg/m²) PO qDay
Maintenance: 1.5-2.5 mg/kg PO qDay in combination with methotrexate
Renal Dose
Renal Impairment: Dosage may need to be reduced.
Contraindication
Pregnancy and lactation. Prior resistance to mercaptopurine or thioguanine; severe liver disease; severe bone marrow suppression.
Mode of Action
Mercaptopurine is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid. The nucleotides inhibit several reactions which ultimately interferes with nucleic acid synthesis and prevents the formation of RNA and DNA.
Precaution
Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) deficiency; porphyria.
Lactation: not known if excreted in breast milk, do not nurse
Side Effect
>10%
Elevated LFT's (15%)
1-10%
Nausea (10%),Vomiting (10%),Stomatitis (3-10%),Thrombocytopenia (3-10%),Rash (1-3%),Diarrhea (1-3%),Dizziness (1-3%),Alopecia (1-3%),Leukopenia (1-3%)
Frequency Not Defined
Fatigue,Anorexia,Headache,Chills and fever,Chest pain,Mucositis,Upper respiratory infection,Cough,Ulceration of intestine,Ulcerative stomatitis,Myelosuppressionm,Decreased hematocrit,Hepatotoxicity,Decreased resistance to infections,Hyperuricemia,Nephrotoxicity,Increased risk of pancreatitis in pts with IBD,Hyperpigmentation of skin,Arthralgias,Eye discomfort,Tinnitus
Potentially Fatal: Myelosuppression; hepatotoxicity, cholestatic jaundice.
Interaction
Anticoagulant action of warfarin may be inhibited by mercaptopurine. Enhanced toxicity with myelosuppressive drugs.
Potentially Fatal: Effects enhanced by allopurinol (reduce dose of mercaptopurine). Other hepatotoxic drugs (e.g. doxorubicin) potentiate toxicity.
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