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Purinol 100
Unimed Unihealth Pharmaceuticals Ltd.
Generic: Allopurinol
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Purinol 100. Please consult your doctor.
CONSULT YOUR DOCTOR
Purinol 100 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Purinol 100 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Purinol 100 may cause side effects which could affect your ability to drive.
Occasionally drowsiness, dizziness or vertigo, ataxia and visual disturbances, may occur when taking Purinol 100. This may affect your driving ability.
CAUTION
Purinol 100 should be used with caution in patients with kidney disease. Dose adjustment of Purinol 100 may be needed. Please consult your doctor.
CAUTION
Purinol 100 should be used with caution in patients with liver disease. Dose adjustment of Purinol 100 may be needed. Please consult your doctor.
Medicine Overview of Purinol 100mg Tablet
Introduction
Purinol 100 is a medicine used to treat and prevent gout. Gout happens when there is too much uric acid in your body and it forms into crystals which can appear around your joints and kidneys and cause pain. This medicine helps to keep uric acid levels low. Purinol 100 should be taken after food. You should keep taking it as recommended by your doctor even when you are not having a gout attack. If you stop, your symptoms may get worse because more crystals form in your joints and kidneys. You can help yourself by making some changes to...
... Show moreUses of Purinol 100
- Gout
Side effects of Purinol 100
Common
- Skin rash
- Diarrhea
- Nausea
How to use Purinol 100
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Purinol 100 is to be taken with food.
How Purinol 100 works
Purinol 100 is a xanthine oxidase inhibitor. It works by decreasing blood uric acid, which is the chemical that causes gout.
What if you forget to take Purinol 100?
If you miss a dose of Purinol 100, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Purinol 100 to reduce episodes of gout attack.
- Take Purinol 100 with food to avoid stomach upset.
- Take plenty of fluids (2-3 litres) daily while on Purinol 100.
- Notify your doctor if you develop a rash. This could be a sign of allergy and should go away on discontinuing Purinol 100.
- When you first start taking this medicine, you might have more gout attacks. Do not stop Purinol 100 on having an acute attack of gout as that could make an attack worse.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Do not consume alcohol while taking this medicine as it may cause your gout to flare up.
Brief Description
Indication
Adult: PO Gout; Hyperuricaemia
Mild: 100 mg/day PO initially; increased weekly to 200-300 mg/day
Moderate to severe: 100 mg/day PO initially; increased weekly to 400-600 mg/day
Prevention of hyperuricaemia associated w/ chemotherapy treatment or enzyme disorders 600-800 mg/day, starting 2-3 days before cancer treatment.
Hepatic impairment: Dose reduction may be needed. Monitor liver function regularly.
Administration
May inhibit the metabolism of mercaptopurine and azathioprine; reduce dose of mercaptopurine and azathioprine when given w/ allopurinol. May increase effect of warfarin and other coumarin anticoagulants. Increased excretion of the oxipurinol (metabolite) w/ salicylates or uricosuric agents. Increased toxicity w/ thiazide diuretics, some antibacterials, other antineoplastics, ciclosporin, some sulfonylurea antidiabetics, theophylline and vidarabine.
Adult Dose
Ensure adequate fluid intake. Prophylactically with an anti-inflammatory or colchicine for at least 1 mth. Withdraw immediately when sensitivity (skin rash, etc) appears. Pregnancy, lactation. Hepatic and renal impairment.
Lactation: Agent is distributed into breast milk; use with caution.
Renal Dose
Allopurinol is an inhibitor of the enzyme xanthine oxidase which converts hypoxanthine to xanthine then uric acid. The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid, there is no risk of nephrolithiasis.
Mode of Action
Administration Should be taken with food. Take immediately after meals.
Precaution
Hyperuricaemia, Uric acid nephropathy, Cancer therapy-induced hyperuricaemia, Gout, Recurrent renal stones
Side Effect
Renal impairment: Haemodialysis: Administer dose after session or administer 50% supplemental dose.
CrCl (ml/min)
10-20 200 mg daily.
<3 100 mg daily at extended intervals.
3-10 100 mg daily.
Pregnancy Category Note
1-10%
Rash (1.5%),Nausea (1.3%),Renal failure (1.2%),Vomiting (1.2%)
Frequency Not Defined
Amblyopia,Arthralgias,Blood dyscrasias,Bronchospasm,Cardiovascular abnormalities,Cataracts,Confusion,Decrease in libido,Dizziness,Ecchymosis,Electrolyte abnormalities,Epistaxis,Foot drop,Hematuria,Hepatotoxicity,Hypotonia,Iritis,Kidney function abnormality,Macular retinitis,Malaise,Neuritis,Pharyngitis,Pruritus,Skin edema,Stevens-Johnson syndrome,Sweating,Tinnitus
Potentially Fatal: Stevens-Jonhson and/or Lyell's Syndrome (urticaria, fever, lymphadenopathy, arthralgia). Occasionally, thrombocytopaenia, agranulocytosis and aplastic anaemia.
Interaction
Hypersensitivity; acute attack of gout.
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