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Pyrin
Quality Pharmaceuticals (Pvt) Ltd.
Generic: Paracetamol
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Pyrin.
SAFE IF PRESCRIBED
Pyrin is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
SAFE IF PRESCRIBED
Pyrin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Pyrin does not usually affect your ability to drive.
CAUTION
Pyrin should be used with caution in patients with kidney disease. Dose adjustment of Pyrin may be needed. Please consult your doctor.
However, Pyrin contains paracetamol which is considered the safest painkiller for kidney disease patients.
CAUTION
Pyrin should be used with caution in patients with liver disease. Dose adjustment of Pyrin may be needed. Please consult your doctor.
However, the use of Pyrin is not recommended in patients with severe liver disease and active liver disease.
Medicine Overview of Pyrin 500mg Tablet
Introduction
Pyrin 500mg is a medicine used to relieve pain and to reduce fever. It is used to treat many conditions such as headache, body ache, toothache and common cold.Pyrin may be prescr500mg ibed alone or in combination with another medicine. You should take it regularly as advised by your doctor. It is usually best taken with food otherwise it may upset your stomach. Do not take more or use it for longer than recommended. Side effects are rare if this medicine is used correctly but this medicine may cause stomach pain, nausea, and vomiting in some people. Consult your doctor...
... Show moreUses of Pyrin
- Pain relief
- Fever
Side effects of Pyrin
Common
- No common side effects seen
How to use Pyrin
Take Pyrin 500mg medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pyrin 500mg is to be taken with food.
How Pyrin works
Pyrin 500mg is an analgesic (pain reliever) and anti-pyretic (fever reducer). It works by blocking the release of certain chemical messengers that cause pain and fever. Pyrin is an analgesic (pain reliever) and anti-pyretic (fever reducer). It works by blocking the release of certain chemical messengers that cause pain and fever.
What if you forget to take Pyrin?
If you miss a dose of Pyrin 500mg, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Pyrin should be taken with food or milk to prevent upset stomach.
- Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
- Do not take indigestion remedies (antacids) within two hours of taking Pyrin.
- Avoid consuming alcohol while taking this medicine as it can increase your risk of stomach problems.
- Inform your doctor if you have liver disease as your dose may need to be adjusted.
- Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
Brief Description
Indication
Fever,
Mild to moderate pain, osteoarthritis, rheumatoid arthritis, chronic low back pain, Renal stone pain, neuropathic pain, toothache, migraine, postoperative mild to moderate pain.
Administration
May be taken with or without food.
Adult Dose
Oral
Mild to moderate pain and fever
Tablet
Adult: 1 - 2 tablets every 4 to 6 hours up to a maximum of 4 g (8 tablets) daily
Extended Release (XR) Tablet
Adults: 2 tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).
Syrup/Suspension:
Adults: 4-8 Measuring spoonful 3-4 times daily;
Rectal
Suppository
Adults: 500 mg-1 g every 4-6 hours to a maximum of 4 g daily.
Child Dose
Oral Mild to moderate pain and fever Tablet Children (6 - 12 years) : 1/2 to 1 tablet 3 to 4 times daily Extended Release (XR) Tablet Children over 12 years: 2 tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours). Syrup Mild to moderate pain and fever Children: 3 months - <1 year : 60 - 120 mg (1/2 - 1 measuring spoonful), 1 - 5 years : 1 - 2 measuring spoonful 6 - 12 years : 2 - 4 measuring spoonful Children: 2 months: 60 mg (1/2 measuring spoonful) for...
... Show moreContraindication
Hypersensitivity.
Mode of Action
Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
Precaution
Patient w/ chronic alcoholism, known G6PD deficiency, severe hypovolaemia, chronic malnutrition. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor serum paracetamol levels esp when acute overdosage is suspected and w/ long-term use.
Side Effect
Thrombocytopenia, leucopenia, pancytopenia, neutropenia, agranulocytosis, pain and burning sensation at inj site. Rarely, hypotension and tachycardia.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalised exanthematous pustulosis, acute renal tubular necrosis and hepatotoxicity.
Interaction
May reduce serum levels w/ anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins w/ prolonged use. Accelerated absorption w/ metoclopramide and domperidone. May increase serum levels w/ probenecid. May increase serum levels of chloramphenicol. May reduce absorption w/ colestyramine w/in 1 hr of admin. May cause severe hypothermia w/ phenothiazine.
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