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Pyrizin
Amulet Pharmaceuticals Ltd.
Generic: Meclizine Hydrochloride + Pyridoxine Hydrochloride
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Pyrizin. Please consult your doctor.
SAFE IF PRESCRIBED
Pyrizin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Pyrizin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Larger doses or prolonged use of Pyrizin may cause sleepiness and other effects in the baby
UNSAFE
Pyrizin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Pyrizin is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Pyrizin may not be needed in these patients. Please consult your doctor.
SAFE IF PRESCRIBED
Pyrizin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Pyrizin may not be needed in these patients. Please consult your doctor.
Medicine Overview of Pyrizin 25mg+50mg Tablet
Introduction
Pyrizin is a combination medicine used in the treatment of vertigo and motion sickness. It prevents the feeling of nausea, vomiting, light-headedness and other symptoms of vertigo. Pyrizin is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you...
... Show moreUses of Pyrizin
- Vertigo
- Motion sickness
Side effects of Pyrizin
Common
- Dryness in mouth
- Allergic reaction
- Drowsiness
- Headache
- Fatigue
How to use Pyrizin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pyrizin may be taken with or without food, but it is better to take it at a fixed time.
How Pyrizin works
Pyrizin is a combination of two medicines: Meclizine and vitamin B6 (pyridoxine) which treat nausea and vomiting associated with pregnancy. Meclizine is an antihistamine which works by blocking the action of a chemical messenger (histamine), thereby controlling nausea, vomiting, and dizziness. Pyridoxine (vitamin B6) is a form of vitamin B which possesses anti-nausea properties.
Quick Tips
- Pyrizin helps treat nausea and vomiting in pregnant women.
- Take it on an empty stomach with a glass of water.
- Pyrizin may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
- Do not take Pyrizin with other sedating medications such as those for cough and cold as the combination could worsen dizziness leading to falls or other accidents.
- Do not take Pyrizin while breastfeeding.
Brief Description
Indication
Nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of vestibular motion sickness, radiation sickness and vertigo associated with diseases of vestibular system, morning sickness during pregnancy, drug induced nausea, vomiting induced by oral contraceptives or Estrogen preparations.
Administration
May be taken with or without food.
Adult Dose
Oral
Motion sickness
Adult: 25-50 mg Meclizine 1 hr before travelling and repeat 24 hrly if needed.
Vertigo and vestibular disorders
Adult: 25-100 mg Meclizine daily in divided doses. Discontinue if there is no response after 1-2 wk of treatment.
Radiation sickness:
50 mg Meclizine administered 2-12 hours prior to radiation treatment.
Pyridoxine (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.
Child Dose
Oral
<12 years: Safety and efficacy not established
Contraindication
Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.
Mode of Action
Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.
Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.
Precaution
Prostate hypertrophy, obstruction of bladder neck, narrow angle glaucoma, pyloric stenosis. May impair ability to drive or operate machinery. Pregnancy.
Lactation: Not known if excreted in milk; use caution
Side Effect
Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.
Interaction
Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.
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