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Safety Advices
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UNSAFE
Rasilez may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Rasilez is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Rasilez is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Rasilez may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Rasilez should be used with caution in patients with kidney disease. Dose adjustment of Rasilez may be needed. Please consult your doctor.
Limited information is available on the use of Rasilez in these patients. Regular monitoring of creatinine and potassium levels is recommended while you are taking this medicine.
CAUTION
Rasilez should be used with caution in patients with severe liver disease. Dose adjustment of Rasilez may be needed. Please consult your doctor.
Limited information is available on the use of Rasilez in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Medicine Overview of Rasilez 150mg Tablet
Introduction
Rasilez is a medicine used in the treatment of high blood pressure (hypertension). It lowers blood pressure by helping in relaxing blood vessels. Lowering the blood pressure helps to prevent future heart attack and stroke. Rasilez should be taken regularly as advised by the doctor. You should take it with or without food and at a fixed time. You should never stop it abruptly without consulting the doctor. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This may lead to your blood pressure rising up again...
... Show moreUses of Rasilez
- Hypertension (high blood pressure)
Side effects of Rasilez
Common
- Diarrhea
- Dizziness
- Joint pain
- Increased potassium level in blood
How to use Rasilez
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rasilez may be taken with or without food, but it is better to take it at a fixed time.
How Rasilez works
Rasilez is a direct renin inhibitor. It works by relaxing blood vessels which lower blood pressure and allows the heart to pump more efficiently.
What if you forget to take Rasilez?
If you miss a dose of Rasilez, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- For better results, take it at the same time every day.
- It may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
- Avoid alcohol while taking Rasilez 150mg Tablet FC as it may increase dizziness.
- Notify your doctor if you have rapid swelling of the lips, tongue, and throat that may cause breathing problem.
- Notify your doctor if you have any kidney problem.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Oral
Essential hypertension
Adult: >18 yr 150 mg once daily, increased to 300 mg once daily if needed.
Elderly: No dosage adjustment needed.
Hepatic impairment: No dosage adjustment needed.
Administration
Increased risk of hypotension w/ other antihypertensives. Increased risk of acute renal failure w/ ACE inhibitors, angiotensin II receptor antagonists or NSAIDs. Antihypertensive effect may be reduced w/ NSAIDs. Increased serum levels w/ atorvastatin, itraconazole, ketoconazole, verapamil. Significant decrease in furosemide concentrations w/ aliskiren. Increased risk of hyperkalaemia w/ potassium-sparing diuretics, potassium supplements or any substances that may increase serum potassium levels.
Potentially Fatal: Increased risk of renal impairment, hypotension and hyperkalaemia w/ ACE inhibitors or angiotensin II receptor antagonists. Markedly increased plasma concentration w/ ciclosporin, itraconazole and quinidine.
Adult Dose
Serious CHF, sodium or volume depletion. Discontinue if diarrhoea is severe and persistent. Lactation. Monitoring Parameters Periodically monitor serum potassium concentration and renal function.
Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death.
Lactation: Excretion in milk unknown/not recommended.
Child Dose
C (1st trimester), D (2nd & 3rd trimesters)
Renal Dose
Aliskiren is an orally active, potent, non-peptide and selective direct renin inhibitor used in the management of HTN. By inhibiting the enzyme renin, it prevents conversion of angiotensinogen into angiotensin I and therefore inhibits subsequent production of angiotensin II and aldosterone. Unlike ACE inhibitors and angiotensin II receptor antagonists which cause a compensatory rise in plasma renin activity, treatment w/ aliskiren decreases plasma renin activity and concentrations of angiotensin I, angiotensin II and aldosterone .
Mode of Action
Administration May be taken with or without food. Take consistently w/ or w/o meals. Avoid taking w/ high fat meals.
Precaution
Hypertension
Side Effect
Renal Impairment Mild to moderate: No dosage adjustment needed. Severe: Contraindicated.
Pregnancy Category Note
1-10%
Diarrhea (2.3%),Cough (1.1%),Rash (1%),Increase in serum creatinine (<7%),Hyperkalemia (<1%)
<1%
Angioedema,Headache,Gout,Renal stones,Seizure,Severe hypotension,Rhabomyolysis,Toxic epidermal necrolysis,Increase in uric acid,Angina
Potentially Fatal: Anaphylactic reactions.
Interaction
History of angioedema; severe renal impairment. Concomitant use w/ ACE inhibitors or angiotensin II receptor antagonists in patients w/ DM and renal impairment (GFR <60 mL/min). Concomitant use w/ ciclosporin, itraconazole and quinidine. Pregnancy.