Introduction
Reumafen 400 is a pain relieving medicine. It is used to treat many conditions such as headache, fever, period pain, toothache, colds, and mild arthritis. It is also a common ingredient in many cold and flu remedies.
Reumafen 400 should be taken with food to avoid stomach upset and reduce side effects. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as it will become less effective if you do.
The medicine is well tolerated with little or no side effects. However, it may cause vomiting, stomach pain, nausea, and indigestion in some people. If any of these side effects do not resolve with time or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.
This medicine is widely prescribed and considered safe but is not suitable for everybody. Before you take it, you should tell your doctor if you have kidney problems, asthma, blood disorders or drink a lot of alcohol. Also, tell your doctor what other medicines you are taking to make sure you are safe. It is best to avoid drinking alcohol while using this medicine.
Side effects of Reumafen 400
Common
- Vomiting
- Stomach pain
- Nausea
- Indigestion
- Heartburn
How to use Reumafen 400
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Reumafen 400 is to be taken with food.
How Reumafen 400 works
Reumafen 400 is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).
Indication
Rheumatoid arthritis, Osteoarthritis, Pain, Fever, Pericarditis, Dysmenorrhea, Patent ductus arteriosus, Inflammation, Musculoskeletal and joint disorders
Administration
Should be taken with food.
Adult Dose
Pain/Fever/Dysmenorrhea
200-400 mg PO q4-6hr; not to exceed 1.2 g unless directed by physician
Inflammatory Disease
400-800 mg PO q6-8hr; not to exceed 3.2 g/day
Osteoarthritis, Rheumatoid Arthritis
300 mg, 400 mg, 600 mg, or 800 mg PO q6-8hr; not to exceed 3.2 g/day
Severe hepatic impairment: Avoid use
Child Dose
Fever
6 months to 12 years
5-10 mg/kg/dose PO q6-8hr; not to exceed 40 mg/kg/day
Pain
4-10 mg/kg/dose PO q6-8hr; not to exceed 40 mg/kg/day
Juvenile Idiopathic Arthritis
30-50 mg/kg/24hr PO divided q8hr; not to exceed 2.4 g/day
Renal Dose
Significantly impaired renal function: Monitor closely; consider reduced dosage if warranted
Contraindication
Active peptic ulcer; hypersensitivity. Neonates with congenital heart disease, suspected necrotising enterocolitis and active bleeding (parenteral).
Mode of Action
Ibuprofen inhibits synthesis of prostaglandins in body tissues by inhibiting cyclooxygenase-1 and 2. It has anti-inflammatory, analgesic and antipyretic properties.
Precaution
Asthma; renal or hepatic disorders; bleeding disorders; CV disease. Pregnancy, lactation.
Lactation: Drug excreted into breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)
Side Effect
1-10%
Dizziness (3-9%),Epigastric pain (3-9%),Heartburn (3-9%),Constipation (1-3%),Nausea (3-9%),Rash (3-9%),Tinnitus (3-9%),Edema (1-3%),Fluid retention (1-3%),Headache (1-3%),Vomiting (1-3%)
<1%
Acute renal failure (sometimes with acute tubular necrosis or hyperkalemia, polyuria, azotemia, cystitis, hematuria, decreased creatinine clearance, elevations in blood urea nitrogen (BUN) or creatinine without other manifestations of renal failure)
Agranulocytosis,Aplastic anemia,Erythema multiforme,Erythematous macular rashes,Exfoliative dermatitis,Hemolytic anemia (with or without positive direct antiglobulin test results),Neutropenia,Thrombocytopenia (with or without purpura),Toxic epidermal necrolysis (Lyell syndrome) and photosensitivity reactions
Potentially Fatal: Severe CV thrombotic events. Severe GI bleeding, ulceration and perforation.
Pregnancy Category Note
Pregnancy category: C; D in 3rd trimester or near delivery. At >30 weeks' gestation; may cause premature closure of ductus arteriosus
Interaction
Increased risk of GI bleeding w/ warfarin, corticosteroids, SSRIs and aspirin. May reduce the natriuretic effects of diuretics. Reduced antihypertensive effect of ACE inhibitors and angiotensin II receptor antagonists. May increase toxicity of lithium and methotrexate. Increased nephrotoxicity w/ ciclosporin and tacrolimus.