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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Rifacol. Please consult your doctor.
CONSULT YOUR DOCTOR
Rifacol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Rifacol is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Rifacol does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Rifacol is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Rifacol may not be needed in these patients. Please consult your doctor.
CAUTION
Rifacol should be used with caution in patients with severe liver disease. Dose adjustment of Rifacol may be needed. Please consult your doctor.
Medicine Overview of Rifacol 550mg Tablet
Introduction
Rifacol is an antibiotic that treats hepatic encephalopathy, a condition in which the liver fails to remove harmful toxins from the blood, leading to brain damage. Symptoms include agitation, confusion, muscle problems, difficulty in speaking and sometimes, coma. Rifacol is also used to treat infectious diarrhea and irritable bowel syndrome with diarrhea (IBS-D) in adults and children. This medicine can be used alone or in combination with other medicines. It may be taken with or without food, preferably at the same time, each day. It should be used in the dose and duration as advised by the doctor. Take it...
... Show moreUses of Rifacol
- Hepatic encephalopathy
Side effects of Rifacol
Common
- Vomiting
- Headache
- Dizziness
- Nausea
How to use Rifacol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rifacol may be taken with or without food, but it is better to take it at a fixed time.
How Rifacol works
Rifacol is an antibiotic. It works by killing the ammonia-producing bacteria in the digestive tract. This treats your infection and relieves symptoms of hepatic encephalopathy (agitation, confusion, muscle problems). This also helps reduce the recurrence of episodes of hepatic encephalopathy.
What if you forget to take Rifacol?
If you miss a dose of Rifacol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Rifacol reduces the risk of overt hepatic encephalopathy (HE) recurrence in patients with liver disease.
- It may cause reddish discoloration of urine. This is normal and harmless.
- Stop taking Rifacol and inform your doctor if you have severe diarrhea during or after using Rifacol.
- Finish the full course of the medication, even if you feel better.
Brief Description
Indication
Traveler's diarrhea, irritable bowel syndrome
Administration
May take with or without food
Adult Dose
Traveler's Diarrhea
200 mg PO q8hr for 3 days
Hepatic Encephalopathy
Maintenance of remission
550 mg PO q12hr
Irritable Bowel Syndrome
Indicated for irritable bowel syndrome with diarrhea (IBS-D) in adult men and women
550 mg PO q8hr for 14 days; recurrence of symptoms can be retreated with a 14 day treatment course, up to 2 times
Child Dose
Traveler's Diarrhea
12 years: 200 mg PO q8hr for 3 days, with or without food
Contraindication
Contraindicated in patients with a hypersensitivity to Rifaximin or to any of the rifamycin antimicrobial agents, or any components of this product.
Mode of Action
Antimicrobial action is a result of binding to the beta-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of transcription.
Hepatic encephalopathy: Inhibits growth of enteric ammonia-producing bacteria to indirectly reduce serum ammonia level.
Irritable bowel syndrome with diarrhea (off-label): Inhibits growth of enteric bacteria to reduce gas production.
Precaution
Rifaximin is not found to be effective in patients with diarrhea complicated by fever and/or blood in the stools. Rifaximin therapy should be discontinued if diarrhea symptoms get worse or persist for more than 24-48 hours and an alternative antibiotic therapy should be considered. Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.
Lactation: Do not use if nursing or do not nurse
Side Effect
>10%
Flatulence (11%)
1-10%
Headache (10%),Rectal tenesmus (7%),Abdominal pain (7%),Defecation urgency (6%),Nausea (5%),Constipation (4%),Pyrexia (3%),Vomiting (2%)
Frequency Not Defined
Hypersensitivity reactions (including allergic dermatitis),Pruritus,Rash
Interaction
Although in vitro studies demonstrated the potential of rifaximin to interact with cytochrome P450 (CYP3A4), a clinical drug-drug interaction study demonstrated that rifaximin did not significantly affect the pharmacokinetics of midazolam. An additional clinical drug-drug interaction study showed no effect of rifaximin on the presystemic metabolism of an oral contraceptive containing ethinyl estradiol and norgestimate. Therefore, clinical interactions with drugs metabolized by human cytochrome P450 isozymes are not expected.
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