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Rifagen 450
Pharmadesh Laboratories Ltd.
Generic: Isoniazid + Rifampicin
Safety Advices
বাংলা
English
UNSAFE
Consuming alcohol while taking Rifagen 450 may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
CONSULT YOUR DOCTOR
Rifagen 450 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Rifagen 450 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Rifagen 450 may cause side effects which could affect your ability to drive.
Rifagen 450 can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
CAUTION
Rifagen 450 should be used with caution in patients with kidney disease. Dose adjustment of Rifagen 450 may be needed. Please consult your doctor.
CAUTION
Rifagen 450 should be used with caution in patients with liver disease. Dose adjustment of Rifagen 450 may be needed. Please consult your doctor.
Use of Rifagen 450 is not recommended in patients with severe liver disease.
Medicine Overview of Rifagen 450 300/450 Tablet
Introduction
Rifagen 450 is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection. Rifagen 450 is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel...
... Show moreUses of Rifagen 450
- Tuberculosis (TB)
Side effects of Rifagen 450
Common
- Dark colored urine
- Rash
- Vomiting
- Jaundice
- Fever
- Increased liver enzymes
- Nausea
- Peripheral neuropathy (tingling and numbness of feet and hand)
How to use Rifagen 450
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rifagen 450 is to be taken empty stomach.
Avoid Rifagen 450 with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
How Rifagen 450 works
Rifagen 450 is a combination of two antibiotics: Rifampicin and Isoniazid, which treats tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
Quick Tips
- You have been prescribed Rifagen 450 for the treatment of tuberculosis.
- Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
- Take it on an empty stomach, preferably at the same time everyday.
- It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Avoid drinking alcohol while taking Rifagen 450 as this may increase the risk of side effects on the liver.
- Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Rifagen 450 as it may make hormonal contraceptives such as the pill less effective.
- Do not take indigestion remedies (antacids) within at least two hours of taking Rifagen 450.
Brief Description
Indication
Tuberculosis
Adult Dose
Oral
Tuberculosis
Adult: Each tab contains rifampicin and isoniazid (mg):
50 kg: 2 tab of 300/150 once daily.
Hepatic impairment: Max: 8 mg/kg daily.
Contraindication
Known or suspected hypersensitivity to rifamycins and/or to INH, and/or to any of the excipients including a history of drug-induced hepatitis; acute liver diseases, regardless of their origin; peripheral neuritis.
Mode of Action
Rifampicin and isoniazid are active bactericidal anti-TB drugs which are particularly active against the rapidly growing extracellular organisms and also have bactericidal activity intracellularly. Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts w/ bacterial RNA polymerase but does not inhibit the mammalian enzyme. Cross-resistance to rifampicin has only been shown w/ other rifamycins. It has activity against slow- and intermittently-growing M. tuberculosis. Isoniazid acts against actively growing tubercle bacilli.
Precaution
Use of isoniazid should be carefully monitored in the following:
Daily users of alcohol. Daily ingestion of alcohol may be associated with a higher incidence of isoniazid hepatitis.
Patients with active chronic liver disease or severe renal dysfunction.
Age > 35.
Concurrent use of any chronically administered medication.
History of previous discontinuation of isoniazid.
Existence of peripheral neuropathy or conditions predisposing to neuropathy.
Pregnancy.
Injection drug use.
Women belonging to minority groups, particularly in the post-partum period.
HIV seropositive patients.
Side Effect
Unwanted effects which may occur during continuous daily or intermittent therapy: Rifampicin: Rifampicin may cause reddish discolouration of body fluids and occasionally other body secretions eg, urine, sputum, lacrimal fluid, faeces, saliva and sweat. It may permanently discolour soft contact lenses. Hepatic Effects: Very common (>10%) is an asymptomatic increase in liver enzymes; severe life-threatening hepatic reactions eg, hepatic failure and acute fulminant hepatitis are uncommon (>0.1% and <1%). In isolated cases (<0.01%), a fatal outcome was observed. Renal Effects: Elevations of BUN and serum uric acid, haemolysis, haematuria, interstitial nephritis, renal insufficiency. Gastrointestinal Effects: Nausea, abdominal pains, vomiting or...
... Show moreInteraction
May reduce effectivity of hormonal contraceptives. Reduced absorption w/ antacids. May decrease plasma concentrations of antivirals (e.g. atazanavir, darunavir, fosamprenavir), atovaquone w/ rifampicin. Rifampicin may reduce serum levels of anticonvulsants (e.g. phenytoin), antiarrhythmics (e.g. disopyramide), oral anticoagulants, antifungals (e.g. ketoconazole), barbiturates, ?-blockers, Ca channel blockers (e.g. diltiazem), chloramphenicol, clarithromycin, corticosteroids, ciclosporin, cardiac glycosides, clofibrate, dapsone, diazepam, doxycycline, fluoroquinolones (e.g. ciprofloxacin), haloperidol, oral hypoglycemic agents (sulfonylureas), levothyroxine, methadone, narcotic analgesics, progestins, quinine, tacrolimus, theophylline, TCAs (e.g. amitriptyline, nortriptyline) and zidovudine. Increased risk of hepatotoxicity w/ halothane. Isoniazid may inhibit the metabolism of anticonvulsants (e.g. carbamazepine, phenytoin), benzodiazepines (e.g. diazepam), haloperidol, ketoconazole,...
... Show moreব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
Register
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Rifagen 450
Pharmadesh Laboratories Ltd.
Generic: Isoniazid + Rifampicin
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৳50
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৳40
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৳20
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৳10
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.