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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Rimactane.
CONSULT YOUR DOCTOR
Rimactane may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Rimactane is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Rimactane may cause side effects which could affect your ability to drive.
You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.
CAUTION
Rimactane should be used with caution in patients with kidney disease. Dose adjustment of Rimactane may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Rimactane in patients with liver disease. Please consult your doctor.
Medicine Overview of Rimactane 450mg Tablet
Introduction
Rimactane is an antibiotic, used in the treatment of all forms of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body. It may be used alone or in combination with other medicines to fight serious infections. Rimactane may also be used alongside other medicines for the treatment of leprosy. This medicine may also be given to people who are carriers (people who are infected, yet do not show any signs and symptoms of infection). Rimactane should be taken on an empty stomach, at least 30 minutes before a meal or 2...
... Show moreUses of Rimactane
- Tuberculosis (TB)
Side effects of Rimactane
Common
- Low blood platelets
- Headache
- Dizziness
- Vomiting
- Abnormal liver function tests
- Nausea
- Fever
- Chills
How to use Rimactane
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Rimactane is to be taken empty stomach.
How Rimactane works
Rimactane is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce.
What if you forget to take Rimactane?
If you miss a dose of Rimactane, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Rimactane to cure your infection and improve symptoms.
- It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food.
- Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.
- Tell your doctor about all other medicines you are taking as Rimactane can interact with many medicines.
- Avoid taking hormone-based birth control methods as Rimactane may decrease their effectiveness.
- Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.
Brief Description
Indication
Tuberculosis, Leprosy, Brucellosis, Meningitis , Legionnaire's disease; Staphylococcal infections
Administration
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals.
Adult Dose
Oral
Tuberculosis
Adult: 10 mg/kg/day or 2-3 times/wk. Max: 600 mg/day.
50 kg: 600 mg daily.
Leprosy
600 mg once mthly.
Prophylaxis against meningococcal meningitis
600 mg twice daily for 2 days.
Prophylaxis against meningitis due to Haemophilus influenzae
600 mg/day for 4 days.
Hepatic impairment: Max: 8 mg/kg/day.
Child Dose
Oral
Tuberculosis
10–20 mg/kg, max 600 mg for TB q24h
With directly observed biweekly therapy, dosage is still 10–20 mg/kg/dose (max 600 mg) twice weekly
20 mg/kg/day for 2 days for meningococcus prophylaxis, q12h
Contraindication
Hypersensitivity to rifampicin or other rifamycins. Patient w/ jaundice. Concurrent use w/ saquinavir/ritonavir therapy.
Mode of Action
Rifampicin suppresses initiation of chain formation for RNA synthesis in susceptible bacteria by binding to the beta subunit of DNA-dependent RNA polymerase, thus blocking RNA transcription.
Precaution
Patient w/ history of alcoholism. Hepatic and renal impairment. Elderly, malnourished patients, childn <2 yr. Pregnancy and lactation. Patient Counselling May permanently stain soft contact lenses. Monitoring Parameters Monitor liver function (AST, ALT, bilirubin), CBC, mental status, sputum culture; chest x-ray 2-3 mth into treatment.
Side Effect
Facial flushing and itching, w/ or w/o a rash, flu-like syndrome characterised by episodes of fever, chills, headache, dizziness, bone pain, shortness of breath, and malaise; GI adverse effects (e.g. nausea, vomiting, anorexia, diarrhoea, epigastric distress), pseudomembranous colitis, eosinophilia, leucopenia, haemolytic anaemia; alterations in kidney function and renal failure, menstrual disturbances, oedema, myopathy, muscular weakness; orange-red discolouration of the urine, faeces, sweat, saliva, sputum, tears, and other body fluids; Rarely, eye irritation and visual disturbances, anaphylaxis or shock.
Potentially Fatal: Hepatotoxicity, hypotension, sinus tachycardia, ventricular arrhythmias, seizures and cardiac arrest, thrombocytopenia and purpura.
Interaction
May accelerate the metabolism and reduce the effect of drugs that are metabolised by CYP450 enzymes (e.g. quinidine, phenytoin, theophylline). Decreased concentrations of atovaquone and increased concentrations of rifampicin when taken concomitantly. Concurrent use of ketoconazole and rifampicin may result in decreased serum concentrations of both drugs. May decrease serum concentrations of enalaprilat. Reduced absorption by antacids. Increased risk of hepatotoxicity w/ halothane or isoniazid.
Potentially Fatal: Increased potential for hepatotoxicity when taken concomitantly w/ saquinavir/ritonavir combination.
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