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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Sebivo.
SAFE IF PRESCRIBED
Sebivo is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Sebivo is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Sebivo may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Sebivo should be used with caution in patients with kidney disease. Dose adjustment of Sebivo may be needed. Please consult your doctor.
Regular monitoring of kidney function tests may be advised before you start taking this medicine and while you are taking this medicine.
SAFE IF PRESCRIBED
Sebivo is safe to use in patients with liver disease. No dose adjustment of Sebivo is recommended.
Medicine Overview of Sebivo 600mg Tablet
Introduction
Sebivo is used in the treatment of HIV infection and chronic hepatitis B virus (HBV) infection. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection. Sebivo is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow carefully the instructions for all the medicines that you are given. It can be taken with or without food. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the...
... Show moreUses of Sebivo
- HIV infection
- Chronic hepatitis B virus (HBV) infection
Side effects of Sebivo
Common
- Fatigue
- Headache
- Nausea
- Decreased appetite
- Indigestion
- Fever
- Feeling of discomfort
- Dizziness
- Muscle pain
- Joint pain
- Abdominal distension
- Insomnia (difficulty in sleeping)
- Rash
- Back pain
- Liver damage
How to use Sebivo
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sebivo may be taken with or without food, but it is better to take it at a fixed time.
How Sebivo works
Sebivo is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.
What if you forget to take Sebivo?
If you miss a dose of Sebivo, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Sebivo for the treatment of chronic hepatitis B virus (HBV) infection.
- In combination with other medicines, it is used for the treatment of HIV infections.
- Take it with food, as this increases the absorption of the medicine into the body.
- Sebivo may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- You may still develop infections or other illnesses associated with viral infection while taking this medication.
- You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
- During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
Brief Description
Indication
Chronic hepatitis B
Administration
May be taken with or without food.
Adult Dose
Oral
Chronic hepatitis B
Adult: 600 mg once daily.
Child Dose
Safety and efficacy not established
Child: >16 yr: 600 mg once daily.
Renal Dose
Renal impairment: ESRD: 600 mg 96 hrly, after dialysis session.
CrCl (ml/min) Dosage Recommendation
<30 (not requiring dialysis) 600 mg 72 hrly.
30-49 600 mg 48 hrly.
Contraindication
Hypersensitivity. Lactation. Concurrent use w/ peginterferon alfa-2a.
Mode of Action
Telbivudine is a synthetic thymidine nucleoside analogue. It undergoes intracellular phosphorylation to form its active metabolite, telbivudine triphosphate. Telbivudine triphosphate inhibits hepatitis B viral DNA polymerase; enzyme inhibition blocks reverse transcriptase thus reducing viral DNA replication. It is used in the treatment of chronic hepatitis B infection.
Precaution
Patient w/ cirrhosis, hepatomegaly or other risk factors for liver disease. Renal impairment. Pregnancy. Monitoring Parameters Monitor hepatic function (e.g. AST and ALT) periodically during therapy and for several mth following discontinuation of therapy; renal function; signs and symptoms of peripheral neuropathy or myopathy; serum creatine kinase; hepatitis B virus (HBV) DNA 3-6 mthly during therapy; HBeAg and anti-HBe signs/symptoms of HBV relapse/exacerbation after discontinuation of therapy.
Lactation: not known if distributed in breast milk, do not nurse
Side Effect
>10%
Fatigue (13%),Elevated serum creatinine kinase (11%);
1-10%
Headache (10%),Cough (6%),Diarrhea (6%),Abdominal pain, upper (6%),Nausea (5%),Pharyngolaryngeal pain (5%),Arthralgia (4%),Pyrexia (4%),Rash (4%),Back pain (4%),Dizziness (4%),Abdominal pain (3%),Myalgia (3%),ALT increased (3%),Dyspepsia (3%),Insomnia (3%),Abdominal distension (3%),Pruritus (2%),Hepatitis B exacerbation (2%)
<1%
Peripheral neuropathy,Myopathy/myositis
Potentially Fatal: Lactic acidosis and severe hepatomegaly.
Interaction
Increased risk of peripheral neuropathy when used with peginterferon alfa-2a.
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