12-24 Hours
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Seroxyn HFA 25/250
ACI Limited
Generic: Salmeterol + Fluticasone
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Seroxyn HFA 25/250. Please consult your doctor.
CONSULT YOUR DOCTOR
Seroxyn HFA 25/250 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Seroxyn HFA 25/250 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Medicine Overview of Seroxyn HFA 25/250 25mcg+250mcg Inhaler
Introduction
Seroxyn HFA 25/250 is a combination of two medicines that opens the airways and makes it easier to breathe. It is used in the treatment of asthma (wheezing and shortness of breath) and chronic obstructive pulmonary disorder (a lung disorder in which the flow of air to the lungs is blocked). Your doctor will tell you how often you need to use your inhaler. The effect of this medicine may be noticeable after a few days but will only reach its maximum after a few weeks. This medicine must be used regularly to be effective, so go on taking it...
... Show moreUses of Seroxyn HFA 25/250
- Asthma
- Chronic obstructive pulmonary disease (COPD)
Side effects of Seroxyn HFA 25/250
Common
- Nausea
- Vomiting
- Respiratory tract infection
- Fungal infection of mouth
- Sore throat
- Headache
- Hoarseness of voice
- Cough
- Musculoskeletal (bone, muscle or joint) pain
- Increased heart rate
How to use Seroxyn HFA 25/250
Check the label for directions before use. Shake the inhaler. While you are breathing in from mouth, press down on the inhaler one time to release the medication and hold your breath for 10 seconds. Repeat until you have inhaled the number of puffs as suggested by the doctor.Afterwards, rinse your mouth thoroughly with water and spit it out.
How Seroxyn HFA 25/250 works
Seroxyn HFA 25/250 is a combination of two medicines: Salmeterol and Fluticasone Propionate. Salmeterol is a long-acting bronchodilator which works by relaxing the muscles in the airways and widens the airways. Fluticasone Propionate is a steroid. It works by stopping the release of certain chemical messengers that cause inflammation (swelling) of the airways. Together, they make breathing easier.
Quick Tips
- This medicine is for inhalation only. The tablet should not be swallowed.
- It should be taken at the same time each day.
- It does not work right away and should not be used to relieve sudden breathing problems. Use your rescue inhaler to control sudden difficulty in breathing.
- Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
- Gargle with warm water after each inhalation to avoid any fungal infections in your mouth and throat.
- Take the first dose of this medicine under medical supervision as it may cause wheezing or tightening of the airways (bronchospasm) immediately after using.
- Your doctor may regularly monitor your blood potassium level as low oxygen level in the blood (hypoxia) and medicines such as Seroxyn HFA 25/250 can lower blood potassium level.
- Only miniscule amounts of Seroxyn HFA 25/250 may get absorbed into the bloodstream after inhalation. Hence, serious side effects are unlikely.
Brief Description
Indication
Chronic Asthma, COPD
Adult Dose
Inhalation
Asthma
Adult: As combination containing salmeterol 50 mcg and fluticasone propionate 100/250/500 mcg/dose of inhalation powder:
1 inhalation bid.
As combination containing salmeterol 25 mcg and fluticasone propionate 50/125/250 mcg/dose of pressurised inhalation:
2 inhalation bid.
Chronic obstructive pulmonary disease
Adult: As combination containing salmeterol 50 mcg and fluticasone propionate 500 mcg/dose of inhalation powder:
1 inhalation bid.
Child Dose
Inhalation
Asthma
Child: 4-12 yr:
As combination containing salmeterol 50 mcg and fluticasone propionate 100 mcg/ dose of inhalation powder:
1 inhalation bid;
As combination containing salmeterol 25 mcg and fluticasone propionate 50 mcg/dose of pressurised inhalation:
2 inhalation bid.
>12 yr: As combination containing salmeterol 50 mcg and fluticasone propionate 100/250/500 mcg/dose of inhalation powder:
1 inhalation bid;
As combination containing salmeterol 50/125/250 mcg and fluticasone propionate 50 mcg/dose of pressurised inhalation:
2 inhalation bid.
Contraindication
Not for primary treatment of status asthmaticus or other acute attacks of asthma. Severe hypersensitivity to milk proteins.
Mode of Action
Salmeterol, a long acting beta 2-agonist which acts locally in the lung to mediate bronchodilation. Fluticasone, a corticosteroid with mainly glucocorticoid activity, reduce symptoms and exacerbations of asthma.
Precaution
Pulmonary TB, severe cardiovascular disorders, heart rhythm abnormalities, DM, thyrotoxicosis, hypokalaemia. Patients at risk of decreased bone mineral content (e.g. smoking, old age, sedentary lifestyle, poor nutrition, family history of osteoporosis or long term use of drugs that may decrease bone mass (e.g. anticonvulsants and corticosteroids). Do not stop therapy abruptly; therapy should be down titrated. Advise patient to rinse mouth after inhalation. Monitor height of children on prolonged therapy. Pregnancy, lactation.
Side Effect
>10%
Upper respiratory tract infection (21-27%),Headache (12-21%),Pharyngitis (10-13%)
1-10%
Candidiasis, nonspecific site (0-10%),Throat irritation (7-9%), Musculoskeletal pain (2-9%), Bronchitis (2-8%),Upper respiratory inflammation (4-7%),Viral respiratory infections (4-6%),Nausea or vomiting (4-6%),Cough (3-6%),Sinusitis (4-5%),Hoarseness or dysphonia (2-5%),Fever (3-4%),Diarrhea (2-4%),Gastrointestinal (GI) discomfort or pain (1-4%),Oral candidiasis (1-4%),Muscle cramps or spasms (3%),Malaise or fatigue (2-3%),Viral GI infections (0-3%)
Potentially Fatal: Paradoxical bronchospasm.
Interaction
Increased fluticasone levels with CYP 3A4 inhibitors e.g ritonavir, ketoconazole, itraconazole. Additive effects with other beta-agonist.
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