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Sigtil
The White Horse Pharmaceuticals Ltd
Generic: Sitagliptin
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Sigtil.
SAFE IF PRESCRIBED
Sigtil is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Sigtil is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Sigtil should be used with caution in patients with kidney disease. Dose adjustment of Sigtil may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Sigtil is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Sigtil may not be needed in these patients. Please consult your doctor.
Medicine Overview of Sigtil 25mg Tablet
Introduction
Sigtil is a medicine used to treat type 2 diabetes mellitus. It is used together with a healthy diet and regular exercise to control blood sugar levels. This helps to prevent serious complications of diabetes like kidney damage and blindness. Sigtil is normally prescribed when diet and exercise alone or other medicines do not prove sufficient to control your blood sugar level. Your doctor may prescribe it alone or along with other diabetes medicines. It may be taken on an empty stomach or with a meal. The dose will depend on your condition, and blood sugar levels. Therefore, you should...
... Show moreUses of Sigtil
- Type 2 diabetes mellitus
Side effects of Sigtil
Common
- Headache
- Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
- Upper respiratory tract infection
- Nasopharyngitis (inflammation of the throat and nasal passages)
How to use Sigtil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sigtil may be taken with or without food, but it is better to take it at a fixed time.
How Sigtil works
Sigtil is an antidiabetic medication. It works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces the fasting and postmeal sugar levels.
What if you forget to take Sigtil?
If you miss a dose of Sigtil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Sigtil should be taken at the same time every day since this helps you remember to take it.
- It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- Be careful while driving or operating machinery until you know how Sigtil affects you.
- Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea and/or vomiting.
Brief Description
Indication
Type 2 diabetes mellitus
Administration
May be taken with or without food.
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: 100 mg once daily.
Hepatic impairment
Mild to moderate impairment: Dose adjustment not necessary
Severe impairment: Not studied
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
CrCl >50 mL/min: Dose adjustment not necessary
CrCl 30-50 mL/min: 50 mg PO qDay
CrCl <30 mL/min: 25 mg PO qDay
ESRD: 25 mg PO qDay regardless of hemodialysis
Contraindication
Hypersensitivity reactions such as anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome can occur. Type 1 diabetes. Diabetic ketoacidosis.
Mode of Action
Sitagliptin inhibits dipeptidyl peptidase IV (DPP-IV), resulting in prolonged active incretin levels. Incretin hormones increases insulin synthesis and release from pancreatic beta-cells and reduces glucagon secretion from pancreatic beta-cells. Reduced glucagon secretion leads to decreased hepatic glucose production.
Precaution
Patient w/ type 1 diabetes, history of angioedema. Not intended for the treatment of diabetic ketoacidosis. Moderate and severe renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor glycosylated Hb (HbA1c), serum glucose. Assess renal function prior to initiation of therapy and periodically thereafter.
Lactation: Not known whether excreted in breast milk: use caution
Side Effect
1-10%
Nasopharyngitis (5%),Diarrhea (4%),Headache (3.6%),Constipation (3%),Peripheral edema (2%),Nausea (2%),Pharyngitis (1%),Osteoarthritis (1%),URI (1%)
<1%
Hypersensitivity reactions such as anaphylaxis, angioedema, rash, urticaria, cutaneous vasculitis, and exfoliative skin conditions (including Stevens-Johnson syndrome)
Hepatic enzyme elevations,Acute pancreatitis, including fatal and nonfatal hemorrhagic and necrotizing pancreatitis.Constipation.Vomiting.Worsening renal function, including acute renal failure (sometimes requiring dialysis),Severe and disabling arthralgia,Myalgia,Pain in extremity,Back pain
Interaction
Increased risk of hypoglycaemia when used in combination w/ sulfonylureas or insulin.
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