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Simox
Silva Pharmaceuticals Ltd.
Generic: Amoxicillin
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Simox does not cause any harmful side effects.
SAFE IF PRESCRIBED
Simox is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Simox is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Simox may cause side effects which could affect your ability to drive.
Simox can have side effects and the symptoms (such as allergic reactions, dizziness and convulsions) may make you unfit to drive.
CAUTION
Simox should be used with caution in patients with kidney disease. Dose adjustment of Simox may be needed. Please consult your doctor.
Use of this medicine is not recommended in patients with severe kidney disease.
CAUTION
Simox should be used with caution in patients with liver disease. Dose adjustment of Simox may be needed. Please consult your doctor.
Regular monitoring of liver function tests is recommended while you are taking this medicine
Medicine Overview of Simox 125mg/5ml Powder for Suspension
Introduction
Simox is a penicillin-type of antibiotic used to treat a variety of bacterial infections. It is effective in infections of the throat, ear, nasal sinuses, respiratory tract (eg. pneumonia), urinary tract, skin and soft tissue, and typhoid fever. Simox is also used to prevent infection of the heart valves (bacterial endocarditis) in people with pre-existing heart disease. Additionally, it helps to eliminate a bacteria known as H. pylori in people with peptic ulcer disease. It is a broad-spectrum antibiotic that fights and stops the growth of many types of bacteria. This medicine is best taken with a meal to reduce...
... Show moreUses of Simox
- Bacterial infections
Side effects of Simox
Common
- Rash
- Vomiting
- Allergic reaction
- Nausea
- Diarrhea
How to use Simox
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Simox may be taken with or without food, but it is better to take it at a fixed time.
How Simox works
Simox is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
- Simox is used to treat infections caused by bacteria.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect. Taking probiotics along with Simox may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking this medicine and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Brief Description
Indication
Adult: PO Susceptible infections 250-500 mg 8 hrly. Uncomplicated gonorrhoea W/ probenecid: 3 g as a single dose. Dental abscesses 3 g, repeat once 8 hr later. Uncomplicated acute UTI 3 g, repeat once 10-12 hr later. Prophylaxis of endocarditis 2 or 3 g as a single dose, 1 hr before dental procedure. Severe or recurrent resp tract infections 3 g twice daily. H.pylori infection W/ either metronidazole or clarithromycin and a bismuth compound or an antisecretory drug: 500 mg 3 times/day. IV/IM Susceptible infections 500 mg 8 hrly. Listerial meningitis W/ other antibiotics: 2 g 4 hrly for 10-14...
... Show moreAdministration
May reduce the efficacy of OC. May increase the effect of anticoagulants. Increased risk of allergic reactions w/ allopurinol. Increased and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin.
Adult Dose
Renal and hepatic disease; pregnancy, lactation; infectious mononucleosis.
Lactation: Excreted in breast milk, use caution
Renal Dose
Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.
Contraindication
Child: PO Standard dose: 40–45 mg/kg/day q8-12h
High dose: 80–90 mg/kg/day, max 4 g/day q12h
150 mg/kg/day div q8h for penicillin-resistant S pneumoniae otitis media
Mode of Action
May be taken with or without food. May be taken w/ meals for better absorption & to reduce GI discomfort.
Precaution
Bacterial infections, Pharyngitis, Acute otitis media, Acute bacterial sinusitis, Endocarditis, Anthrax, Chlamydial cervicitis, Chlamydial urethritis, Lyme disease, Dental abscess, Salmonellosis,Typhoid fever, Acute Uncomplicated gonorrhea, Infections of the Lower Respiratory Tract, Skin and Skin Structure, Genitourinary Tract, Ear, Nose, Throat
Side Effect
Renal impairment: Patients on haemodialysis should receive 250-500 mg every 24 hr and an additional dose during and after each dialysis session.
CrCl (ml/min)
10-30 250-500 mg every 12 hr.
<10 250-500 mg every 24 hr.
Pregnancy Category Note
Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis.
Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis.
Interaction
Hypersensitivity
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