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Simplovir
Incepta Pharmaceuticals Ltd.
Generic: Acyclovir
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Simplovir. Please consult your doctor.
SAFE IF PRESCRIBED
Simplovir is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Simplovir is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Simplovir does not usually affect your ability to drive.
CAUTION
Simplovir should be used with caution in patients with kidney disease. Dose adjustment of Simplovir may be needed. Please consult your doctor.
It is advisable to drink plenty of water while you are taking this medicine.
SAFE IF PRESCRIBED
Simplovir is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Simplovir may not be needed in these patients. Please consult your doctor.
Medicine Overview of Simplovir 400mg Tablet
Introduction
Simplovir is an antiviral medicine. It helps in treating viral infections like herpes labialis, herpes simplex virus infections, shingles, genital herpes infection, and chickenpox. It prevents the multiplication of virus in human cells and therefore helps in clearing the infection. Simplovir should be taken in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Dissolve it in a glass of water before taking it. It may be taken with or without food, but it is better to take it at a fixed time....
... Show moreUses of Simplovir
- Herpes simplex virus infections
- Chickenpox
- Herpes labialis
- Shingles
- Genital herpes infection
Side effects of Simplovir
Common
- Headache
- Dizziness
- Vomiting
- Nausea
- Fatigue
- Fever
- Stomach pain
- Diarrhea
- Skin rash
- Photophobia
How to use Simplovir
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Simplovir may be taken with or without food, but it is better to take it at a fixed time.
How Simplovir works
Simplovir is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.
What if you forget to take Simplovir?
If you miss a dose of Simplovir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Drink plenty of water while on treatment with this medicine. This helps to prevent dehydration and kidney damage.
- If you have genital herpes, use barrier methods (condoms) for contraception and avoid sexual contact while the sores are present.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Brief Description
Indication
Oral Primary herpes simplex infections Adult: 200 mg 5 times daily every 4 hr for 5-10 days; for severely immuno compromised patients and those with impaired absorption: 400 mg 5 times daily for 5 days. Suppression of recurrent herpes simplex Adult: 800 mg daily in 2-4 divided doses. May reduce to 400-600 mg daily if necessary. Reassess the condition every 6-12 mth. For mild or infrequent recurrences: Episodic treatment may be used: 200 mg 5 times daily for 5 days, preferably begun during the prodromal period. Prophylaxis of herpes simplex in immunocompromised patients Adult: 200-400 mg 4 times daily. Varicella...
... Show moreAdministration
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Adult Dose
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration.
Lactation: Drug enters breast milk; use with caution.
Renal Dose
Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Contraindication
Child: PO 900 mg/m2/day q8h
60–80 mg/kg/day (max 4 g/day) q6–8h
Varicella Zoster (Chickenpox)
>2 years and 10 mL/min/1.73 m²: 200 mg q4hr (five times daily)
400 mg every 12 hr
0-10 mL/min/1.73 m²: 200 mg q12hr
>10 mL/min/1.73 m²: 400 mg q12hr
800 mg every 4 hr
0-10 mL/min/1.73 m²: 800 mg q12hr
10-25 mL/min/1.73 m²: 800 mg q8hr
>25 mL/min/1.73 m²: 800 mg q4hr (five times daily)
Mode of Action
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Reconstitution: Add 10 mL or 20 mL of sterile water for inj to a vial labeled as containing 500 mg or 1,000 mg of aciclovir, respectively, to provide a soln containing 50 mg/mL. The appropriate dose of reconstituted soln should then be withdrawn from the vial and diluted w/ 50-125 mL of a compatible IV infusion soln.
Precaution
Herpes simplex infections, Varicella zoster (chickenpox), Herpes zoster (shingles), Genital herpes
Pregnancy Category Note
>10%
Oral
Malaise (<12%)
1-10%
Parenteral
Inflammation or phlebitis at injection site (9%),Nausea (7%),Vomiting (7%),Rash or hives (2%),Elevated transaminase levels (1-2%)
Oral
Nausea (2-5%),Vomiting (<3%),Diarrhea (2-3%),Headache (2%)
<1%
Abdominal pain,Aggression/confusion,Agitation,Alopecia,Anaphylaxis,Anemia,Angioedema,Anorexia,Ataxia,Coma,Disseminated intravascular coagulation (DIC),Dizziness,Fatigue
Potentially Fatal: Occasionally neurotoxicity after IV use: Lethargy, confusion, agitation, tremors, seizures, coma.
Interaction
Hypersensitivity.
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