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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Simvastatin.
UNSAFE
Simvastatin is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Simvastatin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Simvastatin does not usually affect your ability to drive.
CAUTION
Simvastatin should be used with caution in patients with severe kidney disease. Dose adjustment of Simvastatin may be needed. Please consult your doctor.
CAUTION
Simvastatin should be used with caution in patients with liver disease. Dose adjustment of Simvastatin may be needed. Please consult your doctor.
Use of Simvastatin is not recommended in patients with severe liver disease and active liver disease.
Medicine Overview of Simvastatin 10mg Tablet
Introduction
Simvastatin belongs to a group of medicines called statins. It is used to lower cholesterol and to reduce the risk of heart disease. Cholesterol is a fatty substance that builds up in your blood vessels and causes narrowing, which may lead to a heart attack or stroke. Simvastatin is a widely prescribed medicine and is regarded as safe for long-term use. It can be taken with or without food, taking it with food may reduce chances of nausea. Taking it regularly in the evening helps to maximize its effects. Most people with high cholesterol do not feel ill, but stopping...
... Show moreUses of Simvastatin
- High cholesterol
- Prevention of heart attack and stroke
Side effects of Simvastatin
Common
- Abdominal pain
- Constipation
- Headache
- Upper respiratory tract infection
How to use Simvastatin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Simvastatin may be taken with or without food, but it is better to take it at a fixed time.
How Simvastatin works
Simvastatin is a lipid-lowering medication (statin). It works by blocking an enzyme (HMG-CoA-reductase) that is required in the body to make cholesterol. It thus lowers "bad" cholesterol (LDL) and triglycerides, raising the level of "good" cholesterol (HDL).
What if you forget to take Simvastatin?
If you miss a dose of Simvastatin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose
Quick Tips
- It should be taken in the evening after dinner and before sleeping.
- It should be taken in addition to regular exercise and low-fat diet to lower levels of fat in the blood.
- Inform your doctor if you experience fatigue, muscle weakness or muscle pain.
- Your doctor may check your liver function before starting the treatment and regularly thereafter. Inform your doctor if you notice signs of liver problems such as stomach pains, unusually dark urine or yellowing of skin or eyes.
- Inform your doctor if you have kidney disease, liver disease or diabetes before starting treatment with this medicine. If you are diabetic, monitor your blood sugar level regularly as Simvastatin may cause an increase in your blood sugar level.
- Do not take Simvastatin if you are pregnant, planning a pregnancy or breastfeeding.
Brief Description
Indication
Hyperlipidaemias, stroke prevention
Administration
May be taken with or without food.
Adult Dose
Oral Hyperlipidaemias, Hypercholesterolemia Adult: Initially, 10-20 mg once daily. Patients w/ high CV risk or require a large reduction in cholesterol: Initially, 40 mg once daily. May adjust dose at intervals of at least 4 wk to max 80 mg once daily. All doses to be taken in the evening. Patients w/ homozygous familial hypercholesterolaemia: 40 mg once daily in the evening or 80 mg/day in 3 divided doses of 20 mg, 20 mg and an evening dose of 40 mg. Cardiovascular risk reduction Adult: High-risk patients (e.g. patients w/ DM or atherosclerotic CV disease): 20-40 mg once daily. Moderate-risk...
... Show moreChild Dose
Child
Heterozygous familial hypercholesterolaemia:
10-17 yr Initially, 10 mg once daily May increase at intervals of 4 wk to max 40 mg/day.
All doses to be taken in the evening.
Hypercholesterolemia
<10 years: Safety and efficacy not established
Renal Dose
Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Initially, 5 mg once daily w/ close monitoring.
Contraindication
Acute liver disease or unexplained persistent elevations of serum transaminases. Patients of Chinese descent should not take simvastatin 80 mg/day w/ lipid-modifying dose of niacin-containing products (≥1 g). Simvastatin 80 mg should not be started in new patients and to those taking lower doses. Concurrent use w/ potent CYP3A4 inhibitors e.g. itraconazole, ketoconazole, posaconazole, clarithromycin, erythromycin, telithromycin, nefazodone, HIV protease inhibitors (e.g. nelfinavir), boceprivir, telaprevir., gemfibrozil, ciclosporin, danazol, grapefruit juice. Pregnancy and lactation.
Mode of Action
Simvastatin, an antilipemic agent is a competitive inhibitor of HMG-CoA reductase, the enzyme that catalyses the early and rate-limiting step in cholesterol biosynthesis reduces total cholesterol, LDL-cholesterol and triglycerides and increases HDL-cholesterol levels.
Precaution
History of liver disease. Increased risk of rhabdomyolysis in severe infection, hypotension, major surgical trauma, uncontrolled seizures or severe metabolic, endocrine and electrolyte disorder. Alcoholism; premenarcheal females; children <10 yr. Discontinue treatment if there is marked or persistent increase in serum-aminotransferase concentrations. Monitoring Parameters Monitor creatine kinase (CK) periodically and LFT. Discontinue if there is significant or persistent increase in CK levels, serum aminotransferase levels or evidence of myopathy.
Lactation: Contraindicated; potentially unsafe
Side Effect
1-10%
CPK elevation (>3x ULN) (5%),Constipation (2%),Upper respiratory infection (9%),Flatulence (1-2%),Transaminases increased (>3x ULN) (1%),Headache (3-7%),Myalgia (5%),Eczema (5%),Vertigo (5%),Abdominal pain (7%)
<1%
Myalgia,Myopathy,Arthralgia,Arthritis,Eosinophilia,Chills,Angioedema,Rhabdomyolysis,Abdominal pain
Potentially Fatal: Severe rhabdomyolysis with acute renal failure.
Interaction
May increase bleeding risk w/ anticoagulants. Reduced serum levels w/ bosentan, efavirenz and rifampicin. Increased risk of myopathy and rhabdomyolysis w/ colchicine, amiodarone, verapamil and diltiazem. Increased risk of myopathy w/ amlodipine, fusidic acid. Potential reduction of cytotoxic effect of rituximab. Increased hepatotoxicity w/ ezetimibe.
Potentially Fatal: Concurrent use w/ itraconazole, ketoconazole, posaconazole, clarithromycin, erythromycin, telithromycin, nefazodone, niacin, HIV protease inhibitors (e.g. nelfinavir), boceprivir, telaprevir, gemfibrozil, ciclosporin and danazol may increase the risk of myopathy, rhabdomyolysis and acute renal failure.
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.