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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Sintel 400. Please consult your doctor.
CONSULT YOUR DOCTOR
Sintel 400 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Sintel 400 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Sintel 400 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Sintel 400 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Sintel 400 may not be needed in these patients. Please consult your doctor.
CAUTION
Sintel 400 should be used with caution in patients with liver disease. Dose adjustment of Sintel 400 may be needed. Please consult your doctor.
Inform your doctor if you develop signs of jaundice like yellowing of eyes and skin, itching, and clay colored stools while taking this medicine.
Medicine Overview of Sintel 400mg Tablet
Introduction
Sintel 400 is an antiparasitic medicine, used for the treatment of parasitic worm infections. It works by killing the worms that cause infections and stops the infection from spreading. Sintel 400 should be used in the dose and duration as advised by your doctor. Take it with or without food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned. Some people may experience vomiting, dizziness, increased liver enzymes,...
... Show moreUses of Sintel 400
- Parasitic worm infections
Side effects of Sintel 400
Common
- Vomiting
- Dizziness
- Increased liver enzymes
- Nausea
- Loss of appetite
How to use Sintel 400
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sintel 400 may be taken with or without food, but it is better to take it at a fixed time.
How Sintel 400 works
Sintel 400 is an antiparasitic medication. It works by keeping the worms from absorbing sugar (glucose), thereby depleting their energy level. This causes the worms to die and treats your infection.
Quick Tips
- You have been prescribed Sintel 400 to treat a variety of parasitic worm infections.
- It can be harmful to an unborn baby. Do not take it during pregnancy or breastfeeding. Use birth control measures to prevent pregnancy while taking Sintel 400.
- Your doctor may monitor your blood counts and liver function before you start taking this medicine and regularly throughout your treatment.
- Avoid being near people who are sick or have infections. Inform your doctor if you develop signs of infection.
- Do not skip doses and finish the prescribed course, even if you start to feel better. Stopping it early may increase your risk of further infection.
Brief Description
Indication
Echinococcosis
Adult: <60 kg: 15 mg/kg daily in 2 divided doses. Max: 800 mg/day. ?60 kg: 400 mg bid. Admin dose for three 28-day cycles w/ a 14-day drug-free interval in between each cycle.
Neurocysticercosis
Adult: <60 kg: 15 mg/kg daily in 2 divided doses (max: 800 mg/day) for 8-30 days. ?60 kg: 400 mg bid for 8-30 days.
Ancylostoma, Ascariasis, Hookworm, Trichostrongylus
400 mg PO once
Administration
Increased serum concentrations w/ dexamethasone, praziquantel and cimetidine. Decreased serum concentrations w/ aminoquinoline (antimalarials), carbamazepine, phenobarbital, and phenytoin.
Adult Dose
Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.
Lactation: unknown, use caution.
Renal Dose
Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecratory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.
Contraindication
Child: PO 15 mg/kg/day (max 800 mg/day) q12h
Mode of Action
Should be taken with food.
Precaution
Helminthiasis, Echinococcosis, Neurocysticercosis, Enterobiasis, Ascariasis, Hookworm infections, Strongyloidiasis, Giardiasis, Filariasis
Pregnancy Category Note
>10%
Headache,Neurocysticercosis (11%),Hydatid disease (1.3%),Abnormal LFT,Hydatid disease (15.6%),Neurocysticercosis (<1%)
1-10%
Abdominal pain,Hydatid disease (6%),Nausea/vomiting,Hydatid disease (3.7%),Neurocysticercosis (6.2%),Dizziness/vertigo,Hydatid disease (1.2%),Neurocysticercosis (<1%),Increased intracranial pressure,Neurocysticercosis (1%),Meningeal signs,Neurocysticercosis (1%),Alopecia (reversible),Hydatid disease (1.6%),Neurocysticercosis (<1%),Fever,Hydatid disease (1%)
<1% (selected)
Rash,Urticaria,Agranulocytosis,Aplastic anemia,Bone marrow suppression,Granulocytopenia,Pancytopenia,Thrombocytopenia,Hepatitis,Acute liver failure,Acute renal failure
Potentially Fatal: Bone marrow depression.
Interaction
Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.
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