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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Sixtin.
SAFE IF PRESCRIBED
Sixtin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Sixtin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Sixtin should be used with caution in patients with kidney disease. Dose adjustment of Sixtin may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is recommended for dose adjustment.
CAUTION
Sixtin should be used with caution in patients with severe liver disease. Dose adjustment of Sixtin may be needed. Please consult your doctor.
No dose adjustment is recommended for patients with mild to moderate liver disease.
Medicine Overview of Sixtin 2.5mg Tablet
Introduction
Sixtin is a medicine used to treat type 2 diabetes mellitus. It is used together with a healthy diet and regular exercise to control blood sugar levels. This helps to prevent serious complications of diabetes like kidney damage and blindness. You should take it regularly at the same time each day to get the most benefit, and you should not stop unless your doctor recommends. This medicine is helping you to control your blood sugar levels and prevent serious complications in the future. It is important to stay on the diet and exercise program recommended by your doctor while taking...
... Show moreUses of Sixtin
- Type 2 diabetes mellitus
Side effects of Sixtin
Common
- Headache
- Nasopharyngitis (inflammation of the throat and nasal passages)
- Urinary tract infection
- Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
- Upper respiratory tract infection
How to use Sixtin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sixtin may be taken with or without food, but it is better to take it at a fixed time.
How Sixtin works
Sixtin is an antidiabetic medication. It works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces the fasting and postmeal sugar levels.
What if you forget to take Sixtin?
If you miss a dose of Sixtin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Sixtin should be taken at the same time every day since this helps you remember to take it.
- Be careful while driving or operating machinery until you know how Sixtin affects you.
- It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea and/or vomiting.
Brief Description
Indication
Type 2 diabetes
Administration
May be taken with or without food.
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: 2.5 or 5 mg once daily.
Combination therapy: May need to reduce dosage of sulfonylurea or other insulin secretagogues when administered in combination
Coadministration with strong CYP450 3A4/5 inhibitors: Not to exceed 2.5 mg PO qDay
Elderly: No dosage adjustment.
Hepatic Impairment No dosage adjustment.
Child Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment
CrCl >50 mL/min: No dose adjustment required
CrCl <50 mL/min: Not to exceed 2.5 mg PO qDay
ESRD requiring hemodialysis: Not to exceed 2.5 mg PO qDay administered postdialysis
ESRD requiring peritoneal dialysis: Not studied
Contraindication
Documented hypersensitivity (eg, anaphylaxis, angioedema, exfoliative skin conditions)
Mode of Action
Dipeptidyl peptidase IV (DPP-4) inhibition that results in increased incretin hormones and enhanced glycemic control.
Precaution
Renal impairment
Decrease dose with strong CYP450 3A4/5 inhibitors
Coadministration with thiazolidinediones (eg, rosiglitazone, pioglitazone) increases risk for peripheral edema
Pancreatitis reported with saxagliptin; monitor for signs and symptoms and discontinue if pancreatitis suspected
Serious hypersensitivity reactions with saxagliptin reported (typically within the first 3 months of therapy)
History of angioedema
Coadministration with a sulfonylurea or with insulin may increase hypoglycemia; monitor closely and adjust sulfonylurea and/or insulin dose accordingly
Congestive heart failure (CHF) risks. Observe patients for signs and symptoms of heart failure during therapy;
Lactation: Not known whether distributed in breast milk; caution advised
Side Effect
1-10% (selected)
Urinary tract infection (7%),Headache (7%),Hypersensitivity-related events (<4%; eg, urticaria, facial edema),Peripheral edema (<4%; increased incidence when coadministered with thiazolidinediones),Upper respiratory tract infection (3%),Gastroenteritis (2%),Hypoglycemia (1.6%)
Frequency Not Defined
Increased creatinine phosphokinase,Increased creatinine,Idiopathic thrombocytopenic purpura rash
Interaction
Strong CYP3A4/5 inhibitors (eg ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir & telithromycin).
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