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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Siznil.
CONSULT YOUR DOCTOR
Siznil may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Siznil is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Siznil may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Siznil is safe to use in patients with kidney disease. No dose adjustment of Siznil is recommended.
SAFE IF PRESCRIBED
Siznil is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Siznil may not be needed in these patients. Please consult your doctor.
Medicine Overview of Siznil 10mg Tablet
Introduction
Siznil is an antipsychotic medicine. It is used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania. It can also be used to treat depression and bipolar disorders. Siznil may be taken with or without food, preferably in the morning. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. The dose and how often you need it will be decided by your doctor so...
... Show moreUses of Siznil
- Schizophrenia
- Mania
Side effects of Siznil
Common
- Akathisia (inability to stay still)
- Anxiety
- Blurred vision
- Constipation
- Dizziness
- Fatigue
- Headache
- Increased saliva production
- Indigestion
- Insomnia (difficulty in sleeping)
- Nausea
- Parkinsonism
- Restlessness
- Sleepiness
- Tremor
- Vomiting
How to use Siznil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Siznil may be taken with or without food, but it is better to take it at a fixed time.
How Siznil works
Siznil is an atypical antipsychotic. It works by changing the action of certain chemical messengers in the brain that affect thoughts.
Quick Tips
- You have been prescribed Arip MT 5 Tablet for relieving psychotic symptoms and manic episodes.
- It may take 4 to 6 weeks to see full effects on thoughts and mood. Keep taking it as prescribed.
- Your doctor may advise you to take it in the morning if you experience any difficulty in sleeping.
- It may increase your blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood sugar and cholesterol levels regularly.
- Arip MT 5 Tablet may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking the Arip MT 5 Tablet as it may cause excessive drowsiness.
- Talk to your doctor if you notice sudden mood changes, unusual movements or develop suicidal thoughts.
Brief Description
Indication
Adult: PO Schizophrenia Initial: 10-15 mg once daily. Maintenance: 15 mg once daily. Max: 30 mg once daily without regard to food. Dose increment should not be made before 2 weeks, the time needed to achieve steady state.
Bipolar mania 30 mg once daily. May reduce to 15 mg once daily according to tolerability.
Major Depressive Disorder 2-5 mg/day PO initially; increased weekly PRN by <5 mg/day to dose range of 2-15 mg/day
Elderly: Reduce initial dose.
Administration
Drugs that induce CYP3A4 (e.g. carbamazepine) could cause an increase in aripiprazole clearance and lower blood levels. Inhibitors of CYP3A4 (e.g. ketoconazole) or CYP2D6 (e.g. quinidine, fluoxetine or paroxetine) can inhibit aripiprazole elimination and cause increased blood levels. Increased CNS depression with ethanol.
Adult Dose
Patients with known CV diseases (e.g. history of MI, IHD, CCF or conduction abnormalities), cerebrovascular diseases or conditions which would predispose patients to hypotension; Alzheimer's disease and dementia. Caution when operating hazardous machinery, including automobiles when taking aripiprazole. Pregnancy.
Lactation: Excreted in human breast milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Renal Dose
Aripiprazole acts as a partial agonist at D2 and 5-HT1A receptors and as an antagonist at 5-HT2A receptors.
Contraindication
Schizophrenia 13-17 years: 2 mg/day PO initially; increased to 5 mg/day after 2 days; increased to recommended dosage of 10 mg/day after additional 2 days; may subsequently be increased by 5 mg/day; maintenance: 10-30 mg/day Bipolar Mania Acute manic or mixed episodes, either as monotherapy or as adjunct to lithium or valproate 10-17 years: 2 mg/day PO initially; increased to 5 mg/day after 2 days; increased to recommended dosage of 10 mg/day after additional 2 days; may subsequently be increased by 5 mg/day; maintenance: 10-30 mg/day Autism Irritability associated with autistic disorder 1 week to target dosage of 5 mg/day;...
... Show moreMode of Action
May be taken with or without food.
Precaution
Major depressive disorder, Schizophrenia, Acute manic episodes of bipolar disorder, Agitation, Irritability in autism
Pregnancy Category Note
>10%
Weight gain (8-30%),Headache (27%),Agitation (19%),Insomnia (18%),Anxiety (17%),Nausea and vomiting (11-15%),Akathisia (10-13%),Lightheadedness (11%),Constipation (10-11%)
1-10%
Dizziness (10%),Dyspepsia (9%),Somnolence (5-8%),Fatigue (6%),Restlessness (6%),Tremor (6%),Dry mouth/xerostomia (5%) ,Extrapyramidal disorder (5%),Orthostatic hypotension (1-5%),Musculoskeletal stiffness (4%),Abdominal discomfort (3%),Blurred vision (3%),Cough (3%),Pain (3%),Myalgia (2%),Rash,Rhinitis
<1%
Altered mental status,Autonomic instability,Dysphagia,Hyperpyrexia,Muscle rigidity,Neuroleptic malignant syndrome (NMS),Seizure,Tardive dyskinesia
Interaction
Hypersensitivity. Lactation. Children <18 yr.
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