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Sizopin 25

Tablet-(25mg)
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Sun Pharmaceutical (Bangladesh) Ltd.

Generic: Clozapine

10 Tablets (1 Strip)
৳ 27
৳ 30
10% OFF
Alternative Brands For Sizopin 25

Medicine Overview of Sizopin 25mg Tablet

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Introduction

Sizopin 25 is a prescription medicine used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave). Sizopin 25 may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may worsen your symptoms. Some common side effects of this medicine include increased sweating, visual disturbance and decreased blood pressure. Please consult your doctor if these side effects do not get better or worse. Before taking this medicine it is important to inform your doctor if your suffering from high body temperature and muscle stiffness (neuroleptic malignant syndrome), have had abnormal tongue or face movements (dyskinesia), heart disease, diabetes, Parkinson's disease, dementia, fits (epilepsy), difficulty in swallowing (dysphagia), or liver problems.

Uses of Sizopin 25

  • Schizophrenia

Side effects of Sizopin 25

Common
  • Increased sweating
  • Visual impairment
  • Decreased blood pressure

How to use Sizopin 25

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sizopin 25 may be taken with or without food, but it is better to take it at a fixed time.

How Sizopin 25 works

Sizopin 25 is an atypical antipsychotics. It works by modulating the action of certain chemical messengers in the brain that affects thoughts.

Quick Tips

  • Sizopin 25 helps treat schizophrenia in people for whom other medicines are ineffective or not tolerated.
  • Take it with or without food, preferably at the same time everyday.
  • It can cause dizziness and sleepiness. Be cautious while driving or doing anything that requires concentration.
  • It may cause low blood pressure and dehydration. Drink plenty of fluids and rise slowly from a sitting or lying position.
  • It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
  • Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
  • Do not stop taking Sizopin 25 without talking to your doctor first as it may cause worsening of symptoms.

Brief Description

Indication

Indicated for reducing risk of recurrent suicidal behavior in patients with schizophrenia, or schizoaffective disorder in patients who are judged to be at chronic risk to re-experience suicidal behavior Treatment-resistant schizophrenia, in patients who fail to respond adequately to standard antipsychotic treatment Psychotic disorders in people with Parkinson's disease, when standard treatment has failed to control symptoms.

Administration

May be taken with or without food.

Adult Dose

Adults: PO: Schizophrenia 12.5 mg PO once daily or q12hr initially; increased daily in increments of 25-50 mg/day, if well tolerated, to achieve target dosage of 300-450 mg/day by end of 2 weeks On occasion, may have to be increased to 600-900 mg/day to obtain acceptable response Maintenance: Generally, patients who respond should continue maintenance treatment on their effective dose beyond the acute episode Psychoses in Parkinson's disease Initial: 12.5 mg/day at night, increase gradually in steps of 12.5 mg up to twice weekly. Usual range: 25-37.5 mg/day at bedtime. Max: 100 mg/day in 1-2 divided doses. Elderly: Lower initial dosage of 12.5-25 mg/day indicated; may be titrated more slowly than in younger adults Hepatic impairment: Use with caution and avoid in symptomatic or progressive liver disease or hepatic failure.

Renal Dose

Renal impairment: Severe: Contraindicated.

Contraindication

History of bone marrow disorders including agranulocytosis, circulatory collapse, alcoholic or toxic psychosis, drug intoxication, uncontrolled epilepsy, severe renal, hepatic or cardiac disease; paralytic ileus. Pregnancy and lactation.

Mode of Action

Clozapine has relatively weak dopamine receptor-blocking activity at D1, D2, D3 and D5 receptors but has high affinity for the D4 receptor. It has also blocking effects on serotonin, ?-adrenergic histamine H1 and cholinergic receptors.

Precaution

Medication should not be stopped abruptly; should be tapered off over 1-2 weeks. If conditions warrant abrupt discontinuation (leukopenia, myocarditis, cardiomyopathy), monitor patient for psychosis and cholinergic rebound (headache, nausea, vomiting, diarrhea). Elderly patients are more susceptible to adverse effects (including agranulocytosis, cardiovascular, anticholinergic, and tardive dyskinesia). Significant risk of agranulocytosis, potentially life-threatening. Leucocyte counts should be monitored regularly and for at least 4 wk after treatment discontinuation. Renal, hepatic or cardiac impairment; prostatic enlargement, narrow-angle glaucoma; elderly; immobilised patients. Lactation: Drug enters breast milk; not recommended (American Academy of Pediatrics Committee states that this is "of concern")

Side Effect

Commonly: Sedation, wt gain, reversible neutropenia, eosinophilia, tachycardia, orthostatic hypotension, dizziness, hypersalivation at night, headache, nausea, vomiting, constipation, urinary incontinence and retention, fatigue, transient fever, abnormalities of glucose homoeostasis and the onset of DM, obsessive compulsive symptoms. Rarely: Anaemia, thrombocytopenia, thrombocythaemia, extrapyramidal disorders including tardive dyskinesia, circulatory collapse w/ cardiac and resp arrest, HTN, dysphagia, parotid gland enlargement, confusion, delirium, thromboembolism, acute pancreatitis, hepatitis and cholestatic jaundice. Potentially Fatal: Agranulocytosis, myocarditis, cardiomyopathy, cardiac arrhythmias, pericarditis/pericardial effusion, neuroleptic malignant syndrome, pulmonary embolism, lower resp tract infection.

Pregnancy Category Note

Pregnancy category: B Neonates exposed to antipsychotic drugs during 3rd trimester of pregnancy are at risk for EPS or withdrawal symptoms after delivery; these complications vary in severity, with some being self-limited and others requiring ICU support and prolonged hospitalization Lactation: Drug enters breast milk; not recommended (American Academy of Pediatrics Committee states that this is "of concern")

Interaction

Increased risk and/or severity of bone marrow suppression w/ bone marrow suppressants (e.g. carbamazepine, chloramphenicol), sulfonamides (e.g. co-trimoxazole), pyrazolone analgesics (e.g. phenylbutazone), penicillamine, cytotoxic agents or long-acting depot inj of antipsychotics. Concomitant use w/ benzodiazepines may increase risk of circulatory collapse which may lead to cardiac and/or resp arrest. Additive CNS depression and cognitive and motor performance interference w/ MAOIs and CNS depressants including antihistamines, benzodiazepines and opioid analgesics. May potentiate effects of anticholinergics or antihypertensives. Increased plasma concentration of highly protein bound substances (e.g. warfarin, digoxin). Decreased plasma concentrations w/ phenytoin. Concomitant use w/ lithium can increase the risk of development of neuroleptic malignant syndrome. Decreased clozapine levels w/ CYP1A2 inducers (e.g. omeprazole). Increased clozapine levels w/ CYP1A2 inhibitors (e.g. fluvoxamine, caffeine, ciprofloxacin).

Buy Sizopin 25 from Arogga

In Bangladesh, you can get the original Sizopin 25. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Sizopin 25 in Bangladesh?

The latest price of Sizopin 25 in Bangladesh is 27৳. You can buy Sizopin 25 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
It is unsafe to consume alcohol with Sizopin 25.
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SAFE IF PRESCRIBED
Sizopin 25 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
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CONSULT YOUR DOCTOR
Sizopin 25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. If Sizopin 25 is used, monitor the baby for excessive sedation. Periodically, keep a check on the baby's white blood cell count as well.
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UNSAFE
Sizopin 25 may cause side effects which could affect your ability to drive. You may feel tired, drowsy, dizzy or you may feel faint while taking ClozapineSizopin 25, especially during the early stages of treatment. This may affect your driving ability.
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CAUTION
Sizopin 25 should be used with caution in patients with kidney disease. Dose adjustment of Sizopin 25 may be needed. Please consult your doctor. Use of Sizopin 25 is may not be advised in patients with severe kidney disease.
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CAUTION
Sizopin 25 should be used with caution in patients with liver disease. Dose adjustment of Sizopin 25 may be needed. Please consult your doctor. Regular monitoring of liver function tests is advisable. Inform your doctor if you experience nausea, vomiting and/or weight loss while taking this medicine.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.