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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Sofenib 200. Please consult your doctor.
CONSULT YOUR DOCTOR
Sofenib 200 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Sofenib 200 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Sofenib 200 does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Sofenib 200 is safe to use in patients with kidney disease. No dose adjustment of Sofenib 200 is recommended.
Regular monitoring of blood tests may be advised while you are taking this medicine.
CAUTION
Sofenib 200 should be used with caution in patients with severe liver disease. Dose adjustment of Sofenib 200 may be needed. Please consult your doctor.
Medicine Overview of Sofenib 200mg Tablet
Introduction
Sofenib 200 belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer. Sofenib 200 should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or...
... Show moreUses of Sofenib 200
- Liver cancer
- Kidney cancer
- Thyroid cancer
Side effects of Sofenib 200
Common
- Fatigue
- Nausea
- Loss of appetite
- Diarrhea
- Abdominal pain
- Hair loss
- Weight loss
- Rash
- Painful blisters on hands and feet
How to use Sofenib 200
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sofenib 200 is to be taken empty stomach.
How Sofenib 200 works
Sofenib 200 is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
What if you forget to take Sofenib 200?
If you miss a dose of Sofenib 200, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Sofenib 200 is used in the treatment of liver, kidney, and thyroid cancer.
- Take it without food, or with a low fat meal and a full glass of water.
- Take it at the same time everyday to maintain consistent levels in your body.
- Women who could get pregnant should use a reliable method of contraception to prevent pregnancy while taking this medicine.
- Your doctor may regularly monitor your blood pressure while you are taking this medicine.
- Inform your doctor if you get a skin rash, or any pain, swelling, and redness of your hands and feet while you are taking this medicine.
- Do not change the dose or discontinue use without consulting your doctor.
Brief Description
Indication
Renal cell carcinoma, Hepatocellular Carcinoma, Thyroid Cancer
Administration
Should be taken on an empty stomach. Take on an empty stomach or w/ a low or moderate fat meal. If the patient intends to have a high fat meal, sorafenib should be taken on an empty stomach at least 1 hr before or 2 hr after meals. Swallow whole, do not chew/crush.
Adult Dose
Oral
Advanced renal cell carcinoma, Hepatocellular Carcinoma, Thyroid Cancer
Adult: 400 mg bid. May continue until patient is no longer responding or unacceptable toxicity occurs.
Hepatic Impairment
Mild to moderate: Dose adjustment not necessary
Severe hepatic impairment: Not studied
Child Dose
Safety and efficacy not established
Renal Dose
Renal Impairment
Mild to moderate: Dose adjustment not necessary
Severe renal impairment: Not studied
Contraindication
Hypersensitivity
Mode of Action
Sorafenib inhibits cell surface and intracellular kinases to reduce proliferation of tumour cells.
Precaution
Interrupt teatment if patient develops cardiac infarction, ischaemia and/or bleeding fatalities. Regular monitoring of BP, CBC and platelet is recommended. Monitor INR in patients who are on treatment with warfarin. Adequate contraception should be used during and for at least 2 wk after stopping treatment. May need to discontinue treatment if severe or persistent hypertension occurs.
Lactation: not known whether distributed in breast milk, discouraged
Side Effect
>10%
Thrombocytopenia (12-46%),Anemia (44%),Diarrhea (43%),Rash/desquamation (40%),Fatigue (37%),Abd pain (31%),Hand-foot skin reaction (30%),Weight loss (30%),Anorexia (29%),Alopecia (27%),Nausea (24%),Lymphopenia (23%),Neutropenia (18%),Hemorrhage (15-18%),Hypertension (9-17%),Vomiting (16%),Constipation (15%),Neuropathy (13%),Dry skin (11%)
1-10%
Headache (10%),Joint pain (10%),Congestive heart failure, MI (1.9%),QT prolonation (rare)
<1%
Acute renal failure,Angioedema and arrhythmia may occur,Bone pain reported
Frequency Not Defined
Stevens-Johnson Syndrome,Hyperthyroidism,Interstitial lung disease
Potentially Fatal: Bleeding fatalities. Hypertensive crisis.
Interaction
Inducers of isoenzyme CYP3A4 e.g. carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampicin may decrease sorafenib plasma concentration. Coadmin with sorafenib may increase the plasma concentration of doxorubicin and irinotecan.
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