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Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Spacef does not cause any harmful side effects.
SAFE IF PRESCRIBED
Spacef is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Spacef is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Spacef, since it may have possible effects such as rash and diarrhea.
UNSAFE
Spacef may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Spacef should be used with caution in patients with kidney disease. Dose adjustment of Spacef may be needed. Please consult your doctor.
CAUTION
Spacef should be used with caution in patients with severe liver disease. Dose adjustment of Spacef may be needed. Please consult your doctor.
Limited information is available on use of Spacef in patients with severe liver disease.
Medicine Overview of Spacef 400mg Tablet
Introduction
Spacef is an antibiotic medicine used to treat a variety of bacterial infections. It is effective in infections of the respiratory tract (eg. pneumonia), urinary tract, ear, nasal sinus, throat, and some sexually transmitted diseases. Spacef should be taken with food to avoid an upset stomach. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this...
... Show moreUses of Zostum-O Tablet
- Bacterial infections
Side effects of Zostum-O Tablet
Common
- Nausea
- Indigestion
- Stomach pain
- Diarrhea
How to use Zostum-O Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Spacef is to be taken with food.
How Zostum-O Tablet works
Spacef is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Zostum-O Tablet?
If you miss a dose of Spacef, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Spacef to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Take it with food to avoid an upset stomach.
- Discontinue Spacef and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Avoid consuming alcohol while taking Spacef as it may cause increased side effects.
Brief Description
Indication
Pharyngitis, Community-acquired pneumonia, Susceptible infections, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis
Administration
Should be taken with food.
Adult Dose
Oral
Community-acquired pneumonia
Adult: 400 mg bid for 14 days.
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg bid for 10 days.
Pharyngitis ; Tonsillitis; Uncomplicated skin and skin structure infections
Adult: 200 mg bid for 10 days.
Child Dose
12 years old: As in adults
Renal Dose
Renal impairment:
CrCl (ml/min)
30-49 Maximum: 200 mg bid
<30 Maximum: 200 mg once daily
Contraindication
Hypersensitivity to Cefditoren, other cephalosporins; or milk proteins. Carnitine deficiency.
Mode of Action
Cefditoren is a third generation cephalosporin used for treatment of susceptible infections caused by gram-positive and gram-negative bacteria. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Precaution
Pregnancy and lactation. Patients with penicillin allergy. Avoid prolonged use as pivalate-containing compounds may cause carnitine deficiency over time; greater risk of carnitine deficiency in patients with renal impairment or decreased muscle mass. May decrease prothrombin activity especially in patients with renal or hepatic impairment, poor nutritional status, prolonged antibiotic treatment or patients previously stabilised on anticoagulant therapy. Long term use may result in development of drug-resistant bacteria, or superinfection including Clostridium difficile-associated diarrhoea and pseudomembranous colitis.
Lactation: excretion in milk unknown; use with caution
Side Effect
>10%
Diarrhea (11-15%)
1-10%
Nausea (4-6%),Headache (2-3%),Abdominal pain (2%),Dyspepsia (1-2%),Vomiting (1%)
<1%
Bacterial/fungal superinfection,C. difficile colitis,Hypersensitivity,Increased bleeding time,Stevens-Johnson syndrome,Vaginal moniliasis
Potentially Fatal: Hypersensitivity, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Pregnancy Category Note
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interaction
Reduced oral bioavailability when coadministered with antacids or H2-receptor antagonists. Probenecid may increase plasma concentration and prolong half-life of Cefditoren. May enhance anticoagulant effect of vitamin K antagonists (e.g. warfarin).
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