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Sudofen
Virgo Pharmaceuticals Ltd.
Generic: Pseudoephedrine Hydrochloride
Medicine Overview of Sudofen 60mg Tablet
বাংলা
English
Indication
Nasal congestion
Administration
May be taken with or without food.
Adult Dose
Oral
Nasal congestion
Adult: 1 tablet (60 mg) every 4-6 hr. Max: 4 tab in 24 hr.
Child Dose
Oral
Nasal congestion
Children : 6 - 12 years of age: 1/2 tablet (30 mg) 3-4 times daily.
2 - 5 years of age: 1/4 tablet (15 mg) every 3-4 times daily.
Contraindication
Hypersensitivity, Severe hypertension and coronary artery disease, Concurrent use of Mono Amine Oxidase Inhibitor (MAOI) drugs.
Mode of Action
Pseudoephedrine is both an alpha-and beta-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. It also directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.
Precaution
Hyperthyroidism; ischaemic heart disease, arrhythmia or tachycardia; occlusive vascular disorders e.g. arteriosclerosis, hypertension or aneurysms; DM and closed-angle glaucoma; renal impairment, prostatic enlargement. Pregnancy; lactation.
Lactation: Concentrated in breast milk, Mfr contraindicates (AAP Committee states compatible with nursing)
Side Effect
Anginal pain; rebound congestion and rhinorrhoea; fear, anxiety, restlessness, tremor, insomnia, confusion, irritability and psychotic states; reduced appetite, nausea, vomiting; gangrene; cerebral haemorrhage and pulmonary oedema; reflex bradycardia, tachycardia and cardiac arrhythmias, palpitations and cardiac arrest, hypotension and dizziness, fainting and flushing. Tissue necrosis and sloughing; myocardial and arterial necrosis.
Interaction
Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.
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