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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Sunitix. Please consult your doctor.
CONSULT YOUR DOCTOR
Sunitix is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Sunitix is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Sunitix may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Sunitix is safe to use in patients with kidney disease. No dose adjustment of Sunitix is recommended.
CAUTION
Sunitix should be used with caution in patients with severe liver disease. Dose adjustment of Sunitix may be needed. Please consult your doctor.
Limited information is available on the use of Sunitix in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Medicine Overview of Sunitix 50mg Capsule
Introduction
Sunitix is used in the treatment of kidney cancer and gastrointestinal stromal tumor. Sunitix can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several...
... Show moreUses of Sunitix
- Kidney cancer
- Gastrointestinal stromal tumour
Side effects of Sunitix
Common
- Nausea
- Vomiting
- Weakness
- Rash
- Abdominal pain
- Indigestion
- Discoloration of skin
- Fatigue
- Fever
- Dry skin
- High blood pressure
- Diarrhea
- Constipation
- Painful blisters on hands and feet
- Stomatitis (Inflammation of the mouth)
- Hair discoloration
- Pain in extremity
- Back pain
- Headache
- Joint pain
- Weight loss
- Cough
- Taste change
- Breathlessness
How to use Sunitix
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Sunitix may be taken with or without food, but it is better to take it at a fixed time.
How Sunitix works
Sunitix is an anti-cancer medication. It works by binding and blocking certain cell surface protein (tyrosine kinase) responsible for the propagation of cancer growth. It also restricts the growth of new blood vessels within the tumor. This is how it prevents the proliferation of malignant cancers.
What if you forget to take Sunitix?
If you miss a dose of Sunitix, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Sunitix is used for the treatment of thyroid cancer.
- Take it with or without food, preferably at the same time each day.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it.
- It may affect wound healing time. Be careful while shaving, cutting fingernails or toenails, or using sharp objects.
- Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting.
- Monitoring of thyroid gland function is required while taking this medicine. Inform your doctor if you notice symptoms of weight gain, dry skin, and hair.
- It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools.
- Inform your doctor about the consumption of Sunitix before going for surgical procedure.
- Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Leukemia, Renal cell carcinoma, Gastrointestinal stromal tumor, Meningioma
Administration
May be taken with or without food.
Adult Dose
Hepatic Impairment
Mild to moderate impairment: Dose adjustment not necessary for initial dose; monitor subsequent doses
Severe impairment: Not studied
Child Dose
Safety and efficacy not established
Renal Dose
Renal Impairment
No dose adjustment necessary
Contraindication
Hypersensitivity, Renal impairment
Mode of Action
Multikinase inhibitor (including VEGF & PDGF receptor tyrosine kinases) some of which are implicated in tumor growth, angiogenesis, and metastasis.
Precaution
CHF, HTN, history of QT interval prolongation, patients taking antiarrhythmics or w/ preexisting cardiac disease, bradycardia or electrolyte disturbances, hemorrhagic events, hypothyroidism. Perform CBC & physical exam. May affect ability to drive or operate machinery. Pregnancy.
Side Effect
>10% Dyspepsia (MRCC 46%),Altered taste (MRCC 43%; GIST 21%),Fatigue (GIST 42%; MRCC 74%),Diarrhea (GIST 40%; MRCC 55%),Rash (MRCC 38%; GIST 14%),Vomiting (MRCC 37%; GIST 24%),Constipation (MRCC 34%; GIST 20%),Skin discoloration (MRCC 33%; GIST 30%),Abdominal pain (GIST 33%; MRCC 20%),Nausea (GIST 31%; MRCC 54%),Anorexia (MRCC 31%; GIST 33%),Mucositis/stomatitis (GIST 29%; MRCC 53%),Dyspnea (MRCC 28%; GIST 10%),HTN (MRCC 28%; GIST 15%),Arthralgia (MRCC 28%; GIST 12%),Bleeding (MRCC 26%; GIST 18%),Headache (MRCC 25%; GIST 13%),Asthenia (GIST 22%),Lymphopenia (MRCC 21%),Fever (GIST 18%; MRCC 15%),Limb pain (MRCC 18%),Back pain (MRCC 17%; GIST 11%),Myalgia (MRCC 17%; GIST 14%),Cough (MRCC 17%; GIST 8%),Dry skin (17%),Hair color changes (17%),Neutropenia...
... Show moreInteraction
Increased plasma conc w/ strong CYP3A4 inhibitors (eg ketoconazole, ritonavir, itraconazole, erythromycin, clarithromycin, grapefruit juice). Decreased plasma conc w/ strong CYP3A4 inducers [eg rifampin, dexamethasone, phenytoin, carbamazepine, phenobarb, St. John's wort (Hypericum perforatum)]. Anticoagulants eg warfarin, acenocoumarol (periodically monitor platelets, prothrombin time/INR & physical exam).
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