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Safety Advices
বাংলা
English
UNSAFE
Alcohol can increase the risk of stomach upset and bleeding when taken with Tendonil .
CONSULT YOUR DOCTOR
Tendonil is not recommended for use during pregnancy.
UNSAFE
Tendonil is not safe use during breastfeeding.
CAUTION
Tendonil can have side effects that can impair ability to drive safely. such as: Dizziness
,Drowsiness, Blurred vision ,Confusion, Impaired coordination .It is best to avoid driving while taking Tendonil .
CAUTION
Tendonil should be used with caution in patients with renal impairment.In patients with severe kidney disease, Tendonil is not recommended.
CAUTION
Tendonilshould be used with caution in people with liver disease.The dose ofTendonil may need to be adjusted in people with liver disease.Tendonilcan cause liver damage, especially in people who take high doses of the medication for a long period of time.
Medicine Overview of Tendonil 60mg Capsule
Introduction
Tendonil is a nonsteroidal anti-inflammatory. It is also known as a nonsteroidal anti-inflammatory drug. It works by inhibiting cyclooxygenase (also known as COX), a substance in the body that is involved in the production of irritant chemicals in response to injury or rheumatic disease. Tendonil relieves pain and inflammation by inhibiting COX action.
Uses of Tendonil
Tendonil use as a treatment of pain and inflammation.
Side effects of Tendonil
Sometimes it causes
- Diarrhea
- Vomiting
- Nausea
- Abdominal pain
- Dizziness
- Drowsiness
- Peptic ulceration
- Heartburn
- Indigestion
- Stomach upset
- Headache
How to use Tendonil
Take Tendonilin the dose and duration prescribed by doctor. Swallow it whole. Don't chew, crush, or break it. Tendonil should be taken with food.
How Tendonil work
Tendonil works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins. Prostaglandins are involved in a variety of bodily functions, including pain, inflammation, and fever. By inhibiting COX, acemetacin reduces the production of prostaglandins, which leads to a decrease in pain, inflammation, and fever.
What if you forget to take Tendonil ?
Take Tendonil as soon as you remember .If it is almost time for your next dose, skip the missed dose and take next dose at the regular time. Do not take two doses at the same time.
Brief Description
Indication
It is indicated for the symptomatic treatment of pain and swelling caused by acute joint inflammation in rheumatoid arthritis, osteoarthritis, low back pain, and postoperative pain. It is also indicated for the treatment of chronic inflammation of the joints in the presence of rheumatoid arthritis, ankylosing spondylitis, irritation in the joints and spinal column caused by degenerative disorders, inflammatory soft-tissue rheumatism syndrome, and painful swelling and inflammation caused by injury.
Administration
Acemetacin should be taken with food, milk or an antacid to reduce the possibility of gastro-intestinal disturbance.
Adult Dose
The usual starting dose of acemetacin is 60 mg three times a day.
The maximum recommended daily dose is 180 mg.
Child Dose
It has not been approved for use in children under the age of 18.
Renal Dose
For patients with mild to moderate renal impairment (creatinine clearance ≥30 mL/min):
The recommended starting dose of acemetacin is 60 mg twice a day.
The maximum recommended daily dose is 120 mg.
For patients with severe renal impairment (creatinine clearance <30 mL/min):
Acemetacin is not recommended.
Contraindication
Hypersensitivity to acemetacin or other NSAIDs: Acemetacin is contraindicated in people who are allergic to acemetacin or to other NSAIDs
Active peptic ulcer disease or gastrointestinal bleeding: Acemetacin is contraindicated in people who have active peptic ulcer disease or gastrointestinal bleeding.
Acemetacin is not recommended for people with a history of asthma, urticaria, or other allergic reactions to NSAIDs.
Mode of Action
Acemetacin is a nonselective inhibitor of pro-inflammatory mediators produced by the enzyme COX. COX is required for the synthesis of prostaglandin E2 and F2, molecules derived from fatty acids and stored in the cell membrane. Acetometacine is metabolized to produce its major metabolite, indometacin, which is a non-selective COX inhibitor with the ability to inhibit polymorphonuclear leukocyte motility and reduce cerebral flow by modulating the nitric oxide and vasoconstriction pathways.
Precaution
Caution should be taken in elderly people. Allergic reactions: Acemetacin can cause allergic reactions, including rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. If you experience any of these symptoms, stop taking acemetacin and seek medical attention immediately. Heart disease: Acemetacin can increase the risk of heart attack and stroke, especially in people with a history of heart disease. The risk is highest in people who take high doses of acemetacin for a long period of time. Stroke: Acemetacin can increase the risk of stroke, especially in people with a history of stroke or other...
... Show moreSide Effect
Common side effects include anorexia, nausea, vomiting, diarrhea and constipation, peptic ulceration, headache, dizziness, and vertigo. Confusion, depression, oedema, chest pain, and elevated blood urea levels are uncommon.
Pregnancy & Lactation Category Note
Pregnancy: Acemetacin should not be taken by women in their third trimester of pregnancy.
Acemetacin should be used with caution in women in their first or second trimester of pregnancy.
Acemetacin can harm the fetus if taken during the third trimester of pregnancy.
Acemetacin can also cause issues during labor and delivery. .
Lactation:
Acemetacin is not recommended for use while breastfeeding.
Acemetacin can pass into breast milk and cause adverse effects in nursing infants.
Interaction
Anticoagulants: Acemetacin can increase the risk of bleeding when taken with anticoagulants, such as warfarin and heparin. Antiplatelet agents: Acemetacin can increase the risk of bleeding when taken with antiplatelet agents, such as aspirin and clopidogrel. Other NSAIDs: Acemetacin can increase the risk of side effects when taken with other NSAIDs, such as ibuprofen and naproxen. Methotrexate: Acemetacin can increase the blood levels of methotrexate, which can lead to an increased risk of side effects. Lithium: Acemetacin can increase the blood levels of lithium, which can lead to an increased risk of side effects. Digoxin: Acemetacin can increase the blood...
... Show moreStorage Condition
Store at temperatures below 25°C. Protect against moisture and light .Keep out of the reach of children.
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.