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Tetrazen
Zenith Pharmaceuticals Ltd.
Generic: Tetracycline Hydrochloride
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Tetrazen does not cause any harmful side effects.
CONSULT YOUR DOCTOR
Tetrazen is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Tetrazen is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Use of Tetrazen is not harmful in short-term because milk levels are low. Prolonged or repeated use may cause staining of babies dental enamel or bone deposition of Tetrazen.
SAFE
Tetrazen does not usually affect your ability to drive.
CAUTION
Tetrazen should be used with caution in patients with kidney disease. Dose adjustment of Tetrazen may be needed. Please consult your doctor.
Use of Tetrazen is not recommended in patients with severe kidney disease.
CAUTION
Tetrazen should be used with caution in patients with liver disease. Dose adjustment of Tetrazen may be needed. Please consult your doctor.
Medicine Overview of Tetrazen 250mg Capsule
Introduction
Tetrazen is an antibiotic medicine used to treat bacterial infections in your body. It is effective in some infections of the lungs, urinary tract, eyes, and others. It kills bacteria, which helps to improve your symptoms and cure the infection. Tetrazen is also used to treat many sexually transmitted diseases. It should be taken on an empty stomach. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being...
... Show moreUses of Tetrazen
- Bacterial infections
Side effects of Tetrazen
Common
- Photosensitivity
- Vomiting
- Nausea
- Diarrhea
How to use Tetrazen
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Tetrazen is to be taken empty stomach.
How Tetrazen works
Tetrazen is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
Quick Tips
- Your doctor has prescribed Tetrazen to cure your infection and improve symptoms.
- It should be taken on an empty stomach.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Do not take antacids or medicines containing zinc or iron at least 2 hours before or 6 hours after taking Tetrazen.
- Discontinue Tetrazen and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Tetrazen affects you.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Acne, Lyme disease, Uncomplicated gonorrhea, Syphilis, Psittacosis, Q fever, Pleural effusions, Rocky Mountain spotted fever, Lymphogranuloma venereum, Mycoplasma pneumoniae, Trachoma, Nongonococcal urethritis
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals w/ a full glass of water, in upright position. May be taken w/ meals to reduce GI discomfort.
Adult Dose
Oral
Susceptible infections
Adult: 250-500 mg 6 hrly. Max: 4 g/day.
Acne
Adult: 250-500 mg daily, in divided doses, for at least 3 mth.
Syphilis
Adult: 500 mg 4 times daily for 15 days.
Gonorrhoea
Adult: 500 mg 4 times daily for 7 days.
Vibrio Cholera
Adult: 500 mg 4 times daily for 3 days
Brucellosis
Adult: 500 mg 4 times daily for 3 wk in combination w/ streptomycin.
Hepatic impairment: Max: 1 g daily.
Child Dose
Oral
Children :
8 y: 25–50 mg/kg/day q6h
not to exceed 3 g/day
Renal Dose
Renal impairment
CrCl 50-80 mL/min: Dose frequency q8-12hr
CrCl 10-50 mL/min: Dose frequency q12-24hr
CrCl <10 mL/min: Dose frequency q24hr
Contraindication
Hypersensitivity; pregnancy, lactation, children; renal impairment.
Mode of Action
Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria and some protozoa.
Precaution
Patient w/ pre-existing SLE, myasthenia gravis. Hepatic and mild to moderate renal impairment. Pregnancy. Patient Counselling Avoid direct exposure to sunlight or UV light. Monitoring Parameters Monitor renal, hepatic and haematologic function test, temp, WBC, cultures and sensitivity, appetite, mental status.
Side Effect
>10%
Discoloration of teeth and enamel hypoplasia (young children)
1-10%
Diarrhea,Nausea,Photosensitivity
<1%
Anorexia,Abdominal cramps,Antibiotic-associated pseudomembranous colitis,Bulging fontanels in infants,Diabetes insipidus syndrome,Esophagitis,Exfoliative dermatitis,Incr ICP,Pericarditis,Pseudotumor cerebri,Pancreatitis,Pruritus,Pigmentation of nails,Vomiting
Potentially Fatal: Anaphylaxis, hepatotoxicity, nephrotoxicity, blood dyscrasias.
Interaction
Impaired absorption w/ antacids containing divalent and trivalent cations (e.g. Al, Ca, Mg), Fe, Zn and Na bicarbonate preparations, kaolin-pectin, bismuth subsalicylate, sucralfate, strontium ranelate, colestipol and colestyramine. May interfere w/ the bactericidal action of penicillin. May potentiate the effect of anticoagulants. May decrease efficacy of oral contraceptives. Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs. May increase the hypoglycaemic effect of insulin and sulfonylureas in patients w/ DM. May increase toxic effects of ergot alkaloids and methotrexate. Potentially Fatal: Concurrent methoxyflurane may result to fatal renal toxicity. Increased risk of benign intracranial HTN w/ vit A...
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