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Tiapine XR 50
General Pharmaceuticals Ltd.
Generic: Quetiapine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Tiapine XR 50.
CONSULT YOUR DOCTOR
Tiapine XR 50 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Tiapine XR 50 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Tiapine XR 50 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Tiapine XR 50 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Tiapine XR 50 may not be needed in these patients. Please consult your doctor.
CAUTION
Tiapine XR 50 should be used with caution in patients with liver disease. Dose adjustment of Tiapine XR 50 may be needed. Please consult your doctor.
Medicine Overview of Tiapine XR 50mg Tablet
Introduction
Tiapine XR 50 is a prescription medicine used in the treatment of schizophrenia (a mental disorder that can result in hallucinations or delusions and also adversely affects a person’s ability to think and behave) and mania. It is also used to treat bipolar disorders. Tiapine XR 50 may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this in the dose and duration as advised by your doctor and if you have missed a dose, take...
... Show moreUses of Tiapine XR 50
- Schizophrenia
- Mania
Side effects of Tiapine XR 50
Common
- Akathisia (inability to stay still)
- Decreased haemoglobin level in blood
- Dizziness
- Dystonia (involuntary muscle contractions)
- Headache
- Increased triglyceride level in blood
- Parkinsonism
- Sleepiness
- Weight gain
How to use Tiapine XR 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tiapine XR 50 may be taken with or without food, but it is better to take it at a fixed time.
How Tiapine XR 50 works
Tiapine XR 50 is an atypical antipsychotic. It works by modulating the action of certain chemical messengers in the brain that affect thoughts.
Quick Tips
- You have been prescribed Tiapine XR 50 for the treatment of schizophrenia and mania.
- It is less likely to cause heart problems and movement disorders than other antipsychotics.
- It may take 4 to 6 weeks to see treatment effects. Keep taking it as prescribed.
- Use caution while driving or doing anything that requires concentration as Tiapine XR 50 can cause dizziness and sleepiness.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
- Do not stop taking it without talking to your doctor first as it may cause worsening of symptoms.
Brief Description
Indication
Schizophrenia, Bipolar disorder, Major depressive disorder
Administration
Extended-release: Should be taken on an empty stomach. Take w/o food or w/ a light meal. Swallow whole, do not chew/crush.
May be taken with or without food.
Adult Dose
Oral Schizophrenia Immediate release Day 1: 50 mg/day PO divided q12hr Days 2-3: Dose increased daily in increments of 25-50 mg q8-12hr to 300-400 mg by day 4; further adjustments can be made in increments of 25-50 mg q12hr at intervals >2 days Dosage range: 150-750 mg/day Extended release Day 1: 300 mg/day PO; subsequently, may be increased by up to 300 mg/day at intervals >1 day Maintenance (monotherapy): 400-800 mg/day Patients who have discontinued therapy for >1 week should have their dose retitrated following initiation of therapy; patients may reinitiate at their previous maintenance dose if discontinued therapy <1...
... Show moreChild Dose
Schizophrenia Immediate release Day 1: 50 mg/day PO divided q12hr Days 2-3: Dose increased daily in increments of 25-50 mg q8-12hr to 300-400 mg by day 4; further adjustments can be made in increments of 25-50 mg q12hr at intervals >2 days Dosage range: 150-750 mg/day Extended release Day 1: 300 mg/day PO; subsequently, may be increased by up to 300 mg/day at intervals >1 day Maintenance (monotherapy): 400-800 mg/day Patients who have discontinued therapy for >1 week should have their dose retitrated following initiation of therapy; patients may reinitiate at their previous maintenance dose if discontinued therapy <1 week...
... Show moreContraindication
Quetiapine is contraindicated in individuals with a known hypersensitivity to this medication or any of its ingredients. Severe CNS depression, bone marrow suppression, coma.
Mode of Action
Quetiapine is an antagonist at multiple neurotransmitter receptors in the brain: Serotonin 5-HT1A and 5-HT2, dopamine D1 and D2, histamine H1 and adrenergic a1 and a2 receptors. It is used in the treatment of schizophrenia and bipolar disorder.
Precaution
Patient w/ CV and cerebrovascular disease, conditions predisposing to hypotension, history of seizures or conditions that lower the seizure threshold, conditions that may increase risk of QT prolongation. Avoid abrupt withdrawal. Elderly w/ dementia-related psychosis. Hepatic or renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause somnolence and impair judgement, thinking or motor skills, if affected, avoid driving, operating machinery or performing hazardous tasks. Monitoring Parameters Closely monitor for worsening of glucose control in patients w/ pre-existing DM. Monitor for possible worsening of depression, suicidal thoughts or unusual changes in behaviour. Measure BP at the beginning of, and...
... Show moreSide Effect
>10%
Dizziness (1-18%),Fatigue (3-14%),Extrapyramidal symptoms (1-13%),Increased diastolic blood pressure (41%),Increased triglycerides (8-22%),Increased total cholesterol (7-18%),Increased appetite (2-12%),Constipation (6-11%),Dry mouth (9-44%),Headache (7-21),Somnolence (18-57%)
1-10%
Abdominal pain (4-7%; dose related),Dyspepsia (2-7%; dose related,Tremor (2-8%),Back pain (3-5%),Postural hypotension (2-7%),Tachycardia (1-6%),Pharyngitis (4-6%),Rhinitis (3-4%),Rash (4%),Blurred vision (1-4%),Arthralgia (1-4%),Myalgia (2%),Neck pain (2%),Dyskinesia (4%),Neutropenia (2%),Hemorrhage (1%)
< 1%
Priapism,Cardiomyopathy, myocarditis,QTc prolongation,Night mares,Pancreatitis,Rhabdomyolysis,Palpitation,Leukocytosis,Epistaxis,Exfoliative dermatitis
Interaction
Increased risk of drowsiness and postural hypotension when used with alcohol. CYP3A4 inducers eg. phenytoin and carbamazepine may decrease plasma levels of quetiapine while CYP3A4 inhibitors eg. ketoconazole and erythromycin may increase its plasma levels.
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