Gonorrhoea, Acute gonorrheal urethritis, Cervicitis and proctitis
Adult Dose
Intramuscular
Gonorrhoea
Adult: 2 g as a single dose. In cases whereby antibiotic resistance is prevalent, 4 g (10 mL) may be given but divided as two 5 mL inj, admin to 2 different inj sites.
Child Dose
Intramuscular
Gonorrhoea
Child: Beyond newborn period and <45 kg: 40 mg/kg as a single dose. Max: 2 g.
Contraindication
Hypersensitivity.
Mode of Action
Spectinomycin binds to 30S subunit of the bacterial ribosome, thus inhibiting protein synthesis. It has modest activity against a wide range of gm+ve and gm-ve organisms, though anaerobic organisms are mostly resistant.
Precaution
Ineffective in the treatment of syphilis and may mask or delay symptoms of incubating syphilis. Pregnancy and lactation. Monitoring Parameters Perform serologic test for syphilis at the time of gonorrhoea diagnosis and 3 mth later.
Side Effect
Nausea, dizziness, fever and chills, insomnia, urticaria, mild to moderate pain after IM inj, alterations in kidney and liver function, decrease in Hb and haematocrit.
Potentially Fatal: Anaphylaxis.
Interaction
May result in lithium toxicity when used concurrently. May increase or prolong the neuromuscular blocking effect of atracurium.
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.