12-24 Hours
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Safety Advices
বাংলা
English
UNSAFE
Tizadin may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Tizadin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Tizadin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Tizadin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Tizadin should be used with caution in patients with kidney disease. Dose adjustment of Tizadin may be needed. Please consult your doctor.
CAUTION
Tizadin should be used with caution in patients with liver disease. Dose adjustment of Tizadin may be needed. Please consult your doctor.
Use of Tizadin is not advised in patients with severe liver disease. Liver function tests are recommended before the start of treatment and then on a regular basis as advised.
Medicine Overview of Tizadin 2mg Tablet
Introduction
Tizadin is a muscle relaxer. It provides relief from the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, stiffness, and muscle spasms. Tizadin can be taken with or without food. Generally, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as this will make the medicine less effective. Some common side effects of this medicine include dry mouth, sleepiness, diarrhea, tiredness, and dizziness. If any of these side effects do not go away...
... Show moreUses of Tizadin
- Muscle relaxation
Side effects of Tizadin
Common
- Dizziness
- Sleepiness
- Dryness in mouth
- Upset stomach
How to use Tizadin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tizadin may be taken with or without food, but it is better to take it at a fixed time.
How Tizadin works
Tizadin is a muscle relaxant. It works on the centres in the brain and spinal cord to relieve muscle stiffness or spasm without reduction in strength. This improves pain and movement of muscles.
What if you forget to take Tizadin?
If you miss a dose of Tizadin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Tizadin provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system.
- Tizadin may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Tizadin as it may cause excessive drowsiness.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking it suddenly without talking to your doctor if you've been on it for a long time.
Brief Description
Indication
Spasticity, Painful muscle spasm
Adult Dose
Oral
Muscle Spasticity
Spasticity associated with multiple sclerosis and spinal cord injury
Initial: 2 mg q6-8hr; no more than 3 doses q24hr
Maintenance: Increase by 2 to 4 mg until satisfactory response is achieved with minimum 1-4 days between dose increments
Not to exceed 36 mg/day
Painful muscle spasm associated with musculoskeletal conditions
Adult: 2-4 mg tid.
Elderly: Not recommended.
Hepatic impairment: Avoid or use with extreme caution.
Child Dose
Child < 18 years: Not recommended
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<25 Initially, 2 mg once daily, gradually increasing the dose before increasing the frequency of admin.
Contraindication
Severe hepatic dysfunction.
Mode of Action
Tizanidine, an alpha2-adrenergic agonist, is a centrally acting muscle relaxant structurally related to clonidine. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.
Precaution
Hepatic or renal insufficiency. Children, elderly, pregnancy and lactation. Monitor LFT regularly. Stop treatment if liver enzymes are raised persistently >3 times upper limit of normal range. Avoid abrupt withdrawal of therapy.
Lactation: May be excreted in breast milk due to lipophilic nature; use caution
Side Effect
>10%
Dry mouth (46-50%),Somnolence (46-50%),Dizziness (16-20%),Asthenia (10-45%)
1-10%
Blurred vision (3%),Constipation (4%),Infection (6%),LFT abnormalities (3-5%),Speech disorder (3%),Vomiting (3%),Urinary frequency (3%),UTI (10%)
Frequency Not Defined
Asthenia,Bradycardia,Hypotension,Orthostatic hypotension,Syncope (rare)
Potentially Fatal: Hepatitis.
Interaction
Potentiates hypotensive effect of antihypertensives. Increased CNS effects with alcohol and CNS depressants. Increased bradycardia with ?-blockers and digoxin. Increased serum concentration of tizanidine with CYP1A2 inhibitors e.g. zileuton, ciprofloxacin and other fluoroquinolones, antiarrhythmics, cimetidine, famotidine, oral contraceptives, aciclovir and ticlopidine. Decreased serum concentrations of tizanidine with rifampicin. Use with caution with drugs that may prolong QT interval.
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