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Tizem
Delta Pharma Limited
Generic: Diltiazem Hydrochloride
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Tizem. Please consult your doctor.
CONSULT YOUR DOCTOR
Tizem may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Tizem is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Tizem may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Tizem is safe to use in patients with kidney disease. No dose adjustment of Tizem is recommended.
However, talk to your doctor if you have any underlying kidney disease. Regular monitoring of kidney function test is advised while you are taking this medicine.
CAUTION
Tizem should be used with caution in patients with liver disease. Dose adjustment of Tizem may be needed. Please consult your doctor.
Medicine Overview of Tizem 60mg Tablet
Introduction
Tizem is used to treat angina (heart-related chest pain), high blood pressure and some types of irregular heartbeats (arrhythmia). It is known as a calcium channel blocker. It works by relaxing blood vessels to lower blood pressure. This helps to reduce the workload of the heart. Tizem may be taken with or without food, but it is better to take it regularly at a fixed time each day as advised by your doctor. Keep using this medicine even if you feel well. If you stop taking it suddenly, your condition may worsen. This medicine is only part of a treatment...
... Show moreUses of Tizem
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
- Arrhythmia
Side effects of Tizem
Common
- Headache
- Constipation
- Dizziness
- Fatigue
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Nausea
- Rash
How to use Tizem
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tizem may be taken with or without food, but it is better to take it at a fixed time.
How Tizem works
Tizem is a calcium channel blocker. It blocks the action of calcium on the heart and blood vessels, thereby widening the blood vessels and allowing more blood and oxygen to reach the heart. This reduces blood pressure and decreases the chances of angina (chest pain).
Quick Tips
- Dilzem 30 Tablet CR slows down the heartbeat and allows the blood vessels in the body to relax.
- This helps prevent angina attacks (chest pain caused by heart disease), certain abnormal heart rhythms, stroke and heart attack.
- It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- It may cause you to feel lightheaded or weak especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down.
- It is best to avoid drinking alcohol while taking Dilzem 30 Tablet CR as it may make the side effects worse.
- Do not stop taking it suddenly without talking to your doctor first.
Brief Description
Indication
Supraventricular tachycardia, Hypertension, Angina, Atrial fibrillation, Arrhythmias, Atrial flutter
Administration
May be taken with or without food.
The capsules should be swallowed whole with a drink of water. They should not be crushed or chewed
Adult Dose
Angina
Conventional tablet: 30 mg PO q6hr; increased every 1 or 2 days until angina controlled (usually 180-360 mg/day PO divided q6-8hr); not to exceed 360 mg/day
SR: 120 mg/day PO; titrate after 7-14 days; maintenance range usually 120-320 mg/day; not to exceed 540 mg/day
Hypertension
Conventional tablet: Initial: 60-120 mg twice daily. Max: 360 mg/day.
SR: Twice-daily dosing: 60-120 mg PO q12hr; may be adjusted after 14 days; maintenance range usually 240-360 mg/day
Hepatic Impairment
Use caution
Renal Dose
Renal Impairment
Use caution
Contraindication
Sick-sinus syndrome; 2nd or 3rd ° AV block; porphyria. Severe congestive cardiac failure; marked bradycardia. Pregnancy and lactation.
Mode of Action
Diltiazem relaxes coronary vascular smooth muscles by inhibiting influx of calcium ions during depolarisation of the vascular smooth muscles and myocardium. It increases myocardial O2 delivery in patients with vasospastic angina and inhibits cardiac conduction, particularly at the SA and AV nodes.
Precaution
Elderly. Hepatic or renal impairment; impaired left ventricular function; prolonged AV periods; DM; hypotension. Avoid abrupt withdrawal and long-term use. Patients with sick-sinus syndrome, preexisting AV block, bradycardia and those taking beta-blockers or digitalis are at risk of developing AV block, bradycardia, asystole or sinus arrest.
Lactation: Drug enters breast milk; because of risk for serious adverse reactions in nursing infants from diltiazem, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Side Effect
>10%
Edema (2-15%),Headache (5-12%)
1-10%
Dizziness (3-10%),AV block (2-8%),Peripheral edema (2-8%),Bradyarrhythmia (2-6%),Headache (1-5%),Hypotension (2-4%),Nausea (3%),Vomiting (2%),Vasodilation (2-3%),Extrasystoles (2%),Flushing (1-2%),Drug-induced gingival hyperplasia (<2%),Myalgia (2%),Diarrhea (1-2%),Constipation (2-4%),Bronchitis (1-4%),Sinus congestion (1-2%),Dyspnea (1-6%),Congestion (1-2%)
< 1%
Increased Alkaline phosphatase as well as ALT and AST,CHF,Thrombocytopenia,Toxic epidermal necrolysis,Hemolytic anemia,Photosensitivity,Extrapyramidal symptoms,Syncope
Pregnancy Category Note
Pregnancy category: C
Lactation: Drug enters breast milk; because of risk for serious adverse reactions in nursing infants from diltiazem, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
Interaction
Increased AV blocking effect w/ clonidine. May increase serum levels of statins (e.g. atorvastatin, lovastatin), carbamazepine, phenytoin. May increase bradycardic affect of amiodarone, digoxin, mefloquine. May enhance antihypertensive effect w/ other antihypertensives (e.g. aldesleukin), antipsychotic. Increased serum levels w/ cimetidine. Decreased serum levels w/ rifampicin, phenobarbital.
Potentially Fatal: IV: May enhance hypotensive effect of IV ?-blockers.
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