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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Avifanz. Please consult your doctor.
CONSULT YOUR DOCTOR
Avifanz is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Avifanz is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Avifanz may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Avifanz is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Avifanz may not be needed in these patients. Please consult your doctor.
CAUTION
Avifanz should be used with caution in patients with liver disease. Dose adjustment of Avifanz may be needed. Please consult your doctor.
Use of Avifanz is not recommended in patients with moderate and severe liver disease.
Medicine Overview of Avifanz 600mg Tablet
Introduction
Avifanz belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It helps to control HIV infection so your immune system can work better. Avifanz reduces the chances of getting HIV-related complications and improves your lifespan. It can be taken empty stomach or with food and is prescribed in combination with other HIV medicines. Taking all these medicines regularly at the right times greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important to keep taking them...
... Show moreUses of Avifanz
- HIV infection
Side effects of Avifanz
Common
- Headache
- Dizziness
- Agranulocytosis (deficiency of granulocytes in the blood)
- Insomnia (difficulty in sleeping)
- Sleepiness
- Vomiting
- Allergic reaction
- Nausea
- Abnormal dreams
- Fatigue
- Increased liver enzymes
- Anxiety
- Fever
- Itching
- Difficulty in paying attention
- Increased triglyceride level in blood
- Rash
How to use Avifanz
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avifanz is to be taken empty stomach.
How Avifanz works
Avifanz prevents the multiplication of HIV virus in human cells, thereby stopping the HIV virus from producing new viruses.
Quick Tips
- Avifanz is used in combination with other medicines for the treatment of HIV (human immunodeficiency virus).
- Take it on an empty stomach, preferably at bedtime to reduce side effects.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
- Your doctor may check your liver function regularly. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- You might experience dizziness or abnormal dreams during initial days of treatment. Consult with a doctor if it bothers you or does not go away.
- Use a reliable method of contraception to prevent pregnancy while taking this medicine.
Brief Description
Indication
HIV infection
Administration
Should be taken on an empty stomach. Take on an empty stomach, preferably at bedtime.
Adult Dose
Oral
HIV infection
Adult: Combined with other antiretrovirals: 600 mg once daily. Dosing at bedtime recommended during 1st 2-4 wk of therapy to improve tolerability.
Hepatic impairment
Mild (Child-Pugh Class A): Dose adjustment not necessary; use caution
Moderate-to-severe (Child Pugh Class B or C): Not recommended
Child Dose
Oral
HIV infection
Child: Combined with other antiretrovirals: >3 yr,
10-14 kg: 200 mg;
15-19 kg: 250 mg;
20-24 kg: 300 mg;
25-32.4 kg: 350 mg;
32.5-39 kg: 400 mg;
>40 kg: 600 mg.
To be taken once daily.
Renal Dose
Renal impairment: No dosage adjustment needed
Contraindication
Severe hepatic impairment; hypersensitivity; lactation.
Mode of Action
Efavirenz, a non-nucleoside reverse transcriptase inhibitor with activity against HIV, blocks the RNA-dependent and DNA-dependent polymerase activities including HIV replication.
Precaution
Mild to moderate liver disease; renal impairment. Monitor liver enzymes and cholesterol. Discontinue if severe skin rash or fever develops; known or suspected hepatitis B or infection. History of mental illness or seizures; elderly. Pregnancy. Children.
Lactation: It is not known whether efavirenz is excreted in milk. It should not be administered to nursing mothers. The CDC advises HIV-infected women not to breast-feed to avoid postnatal transmission of HIV.
Side Effect
>10%
Total cholesterol increased (20-40%),Diarrhea (3-14%, children up to 39%),HDL increased (25-35%),Dizziness (28.1%),Rash (5-26%),Fever (children 21%),Depression (19%),Insomnia (16.3%),Cough (children 16%),Vomiting (3-12%),Anxiety (2-13%),Nausea (2-12%)
1-10%
Neutropenia (2-10%),Pruitis (9%),Impaired concentration (8.3%),Transaminases increased (2-8%),Somnolence (7.0%),Abnormal dreams (6.2%),Amylase increased (6%),Hyperglycemia (2-5%),Dyspepsia (4%),Abdominal pain (2-3%),Anorexia (2%),Hallucinations (1.2%)
Pregnancy Category Note
Pregnancy Category: D
Lactation: Unknown if distributed in human milk; the CDC advises HIV-infected women not to breastfeed to avoid postnatal transmission of HIV
Interaction
Hormonal contraceptives; antibacterial e.g. rifampicin, rifabutin, clarithromycin; enzyme inducers. St. John's wort may decrease serum level. Ethanol (hepatic and CNS adverse effects).
Potentially Fatal: Life-threatening adverse effects when used with terfenadine, astemizole, cisapride, midazolam, triazolam and ergot alkaloids.
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