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Tocef 400
General Pharmaceuticals Ltd.
Generic: Cefixime
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Tocef 400 does not cause any harmful side effects.
SAFE IF PRESCRIBED
Tocef 400 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Tocef 400 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoid prolonged use of Tocef 400, since it may have possible effects such as rash and diarrhea.
SAFE
Tocef 400 does not usually affect your ability to drive.
CAUTION
Tocef 400 should be used with caution in patients with kidney disease. Dose adjustment of Tocef 400 may be needed. Please consult your doctor.
CAUTION
Tocef 400 should be used with caution in patients with liver disease. Dose adjustment of Tocef 400 may be needed. Please consult your doctor.
Medicine Overview of Tocef 400mg Capsule
Introduction
Tocef 400 is an antibiotic belonging to the cephalosporin group, which is used to treat a variety of bacterial infections. It is effective in infections of the respiratory tract (eg. pneumonia), urinary tract, ear, nasal sinus, throat, and some sexually transmitted diseases. Tocef 400 may be taken on an empty stomach or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose will depend on what you are being treated for, but you should...
... Show moreUses of Tocef 400 Tablet
- Bacterial infections
Side effects of Tocef 400 Tablet
Common
- Nausea
- Stomach pain
- Indigestion
- Diarrhea
How to use Tocef 400 Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tocef 400 may be taken with or without food, but it is better to take it at a fixed time.
How Tocef 400 Tablet works
Tocef 400 is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Tocef 400 Tablet?
If you miss a dose of Tocef 400, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Tocef 400 to cure your infection and improve your symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Take it with food to avoid an upset stomach.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Avoid consuming alcohol while taking Tocef 400 as it may cause increased side effects.
- Discontinue Tocef 400 and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Brief Description
Indication
Pneumonia, Pharyngitis, Typhoid fever, Susceptible infections , Sinusitis, Otitis media, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis, Gonococcal urethritis, Acute bronchitis
Administration
May be taken with or without food. May be taken w/ food or milk to reduce GI discomfort.
Adult Dose
Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections
Adult: 200 or 400 mg daily as a single dose or in two divided doses
Gonorrhea: 400 mg as a single dose.
Typhoid fever: 20 mg/kg body weight daily in two divided dose.
The usual treatment of is 7 days.
This may be continued for up to 14 days according to the severity of infection.
Child Dose
Child: PO 8 mg/kg/day if <50 kg q12–24h
For convalescent oral therapy of serious infections, up to 20 mg/kg/day
Child over 12 years:
Capsule: 200 or 400 mg daily as a single dose or in two divided doses
Powder for Suspension & DS Powder for Suspension & Paediatric Drops:
Children above 6 months: 8 mg/kg daily in 1-2 divided doses or
6 months-1year: 75 mg daily
1-4 years: 100 mg daily
5-10 years: 200 mg daily
Typhoid Fever
15-20 mg/kg/day PO divided q12hr for 7-14 days; not to exceed 400 mg/day
<6 months: Safety and efficacy not established
Renal Dose
Renal impairment: Dose reduction is necessary.
CrCl (ml/min)
<20 Max: 200 mg daily.
Contraindication
Hypersensitivity to cephalosporin.
Mode of Action
Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Precaution
History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease.
Lactation: Unknown whether drug is excreted in milk
Side Effect
>10%
Diarrhea (16%)
Frequency Not Defined
Abdominal pain,Candidiasis,Dizziness,Dyspepsia,Elevated transaminases,Eosinophilia,Erythema multiforme,Fever,Flatulence,Headache,Increased blood urea nitrogen (BUN),Increased creatinine,Leukopenia,Nausea,Prolonged prothrombin time (PT),Pruritus,Pseudomembranous colitis,Rash,Serum sickness-like reaction,Stevens-Johnson syndrome,Thrombocytopenia,Urticaria,Vaginitis,Vomiting
Potentially Fatal: Pseudomembranous colitis.
Pregnancy Category Note
Pregnancy Available data from published observational studies, case series, and case reports over several decades with cephalosporin use, including cefixime, in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes Maternal gonorrhea may be associated with preterm birth, low neonatal birth weight, chorioamnionitis, intrauterine growth restriction, small for gestational age and premature rupture of membranes; perinatal transmission of gonorrhea to offspring can result in infant blindness, joint infections, and bloodstream infections Lactation There are no available data on presence of drug in human milk, effects on breastfed infant, or on milk...
... Show moreInteraction
Increased concentrations with probenecid.
Potentially Fatal: May increase prothrombin time with anticoagulants.
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