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Tofranil 25
Nevian Lifescience PLC
Generic: Imipramine Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
Tofranil 25 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Tofranil 25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Tofranil 25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Tofranil 25 may cause side effects which could affect your ability to drive.
As Tofranil 25 may impair your alertness or cause drowsiness or blurred vision, and this may affect your ability to drive.
CAUTION
Tofranil 25 should be used with caution in patients with kidney disease. Dose adjustment of Tofranil 25 may be needed. Please consult your doctor.
CAUTION
Tofranil 25 should be used with caution in patients with liver disease. Dose adjustment of Tofranil 25 may be needed. Please consult your doctor.
Regular monitoring of liver function tests is recommended while you are taking this medicine.
Medicine Overview of Tofranil 25mg Tablet
Introduction
Tofranil 25 is known as a tricyclic antidepressant. It is used to treat depression and bedwetting in children of age 6 years and above. It is also effective in treating depression that is unresponsive to other treatments. Tofranil 25 works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided...
... Show moreUses of Tofranil 25
- Depression
- Bed-wetting
Side effects of Tofranil 25
Common
- Increased heart rate
- Blurred vision
- Dryness in mouth
- Difficulty in urination
- Constipation
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
How to use Tofranil 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tofranil 25 may be taken with or without food, but it is better to take it at a fixed time.
How Tofranil 25 works
Tofranil 25 is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.
What if you forget to take Tofranil 25?
If you miss a dose of Tofranil 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Tofranil 25 is used for the treatment of depression and bedwetting in children.
- The main dose should be taken at night as this medicine may produce drowsiness or sleepiness.
- You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood.
- Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine.
- Do not drive or do anything that requires concentration until you know how this medicine affects you.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Depression, Nocturnal enuresis
Administration
May be taken with or without food.
Adult Dose
Oral
Depression
Adult: Initially, 75 mg in divided doses, may gradually increase to 150-200 mg daily as necessary. Max: 300 mg/day. May give in divided doses or single dose HS
Maintenance dose: 50-100 mg PO qDay
Elderly: 10 mg daily, may gradually increase to 30-50 mg daily.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Oral
Nocturnal enuresis
Child: 6-7 yr 20-25 kg: 25 mg;
8-11 yr 25-35 kg: 25-50 mg;
>11yr 35-54 kg: 50-75 mg.
Doses are given just before bedtime. Max treatment duration: 3 mth.
Contraindication
Any degree of heart block or cardiac arrhythmias, recent MI, porphyria, narrow-angle glaucoma, urine retention, mania. Severe hepatic impairment. Childn <6 yr. Concomitant use w/ MAOIs.
Mode of Action
Imipramine is believed to increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibition of their reuptake by the presynaptic neuronal membrane. However, additional receptor effects have been found including desensitisation of adenyl cyclase, down regulation of β-adrenergic receptors, and down regulation of serotonin receptors.
Precaution
Imipramine should be used cautiously and with close physician supervision in people, especially the elderly, who have benign prostatic hypertrophy, urinary retention, and glaucoma, especially angle-closure glaucoma. The sedative effect is increased when imipramine is taken with other central nervous system depressants, such as alcoholic beverages, sleeping medications, other sedatives, or antihistamines. Imipramine may increase heart rate and stress on the heart. It may be dangerous for people with cardiovascular disease, especially those who have recently had a heart attack, to take this drug or other antidepressants in the same pharmacological class. Older people and persons with a history of...
... Show moreSide Effect
Orthostatic hypotension, HTN, tachycardia, palpitation, MI, arrhythmias, heart block, ECG changes, precipitation of CHF, stroke; confusional states (esp in elderly) w/ hallucinations, disorientation, delusions; anxiety, restlessness, agitation, insomnia and nightmares, hypomania, exacerbation of psychosis; numbness, tingling, paraesthesias of extremities; incoordination, ataxia, tremors, peripheral neuropathy, extrapyramidal symptoms, seizures, altered EEG patterns, tinnitus; dry mouth; rarely, associated SL adenitis; blurred vision, accommodation disturbances, mydriasis, constipation, paralytic ileus, urinary retention, delayed micturition, dilated urinary tract; skin rash, petechiae, urticaria, itching, photosensitization, oedema, drug fever; bone marrow depression, agranulocytosis; eosinophilia, purpura, thrombocytopenia; nausea and vomiting, anorexia, epigastric distress, diarrhoea, peculiar taste, stomatitis, abdominal cramps,...
... Show moreInteraction
Increased plasma levels and effects with quinidine, cimetidine, SSRIs, propafenone, flecainide. Reduced plasma levels with barbiturates, phenytoin. May increase effects of anticholinergic drugs. Severe orthostatic hypotension with altretamine. Causes drowsiness and impaired performance in combination with alcohol.
Potentially Fatal: Severe hypertension with adrenaline, noradrenaline and methylphenidate. Reduces hypotensive effects of guanethidine, bethanidine, debrisoquine, bretylium, methyldopa and clonidine. Possible serotonin syndrome with MAOIs, separate admin by 3 wk.
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